ID N4U6Y2_FUSC1 Unreviewed; 669 AA.
AC N4U6Y2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=FOC1_g10001596 {ECO:0000313|EMBL:ENH70919.1};
OS Fusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1229664 {ECO:0000313|EMBL:ENH70919.1, ECO:0000313|Proteomes:UP000016928};
RN [1] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB730175; ENH70919.1; -; Genomic_DNA.
DR AlphaFoldDB; N4U6Y2; -.
DR STRING; 1229664.N4U6Y2; -.
DR VEuPathDB; FungiDB:FOC1_g10001596; -.
DR HOGENOM; CLU_010969_1_0_1; -.
DR OMA; NDYGPNS; -.
DR Proteomes; UP000016928; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06564; GH20_DspB_LnbB-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43678:SF1; BETA-N-ACETYLHEXOSAMINIDASE; 1.
DR PANTHER; PTHR43678; PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000016928};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..669
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004120610"
FT DOMAIN 126..293
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 285
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 669 AA; 74993 MW; D7C14DDD1C2000B6 CRC64;
MRIQSLNTWV VAFLVTSAEC AKLLTIPSVA CQNNRGDRYN VERIESITVD TRFATSVDKD
GQILIPPTLS QFAETFRNDV APLVGRKLRL DPLGAWWGTR TIFQALALNG YLPHGSMTDS
PGWGSRGVML DIGRHYYPPE FLVEMCSYLS IWKQNQFHLH INDNLFINFD LYTDKQMREL
YSAFRLSSTS PALAGLASPA NESYTHAQFE WIQRQCAARG VTIIPEIDAP AHALAITKWK
PELALSGNPS MLNISHPGTI PTLKTLWKTF LPWFHTKTVH LGADEYNTTM VSQYNKLVDE
LYHFVSQSNK KARIWGTFPP SKGGKYTKDV VIQHWAPYED NAYFDFIKKG YKVLNSDFLF
YISSKWHGYF GQTLNKTLIF GGNPEGGAFA PHIFDAKNAT NNPPRDSPGV MGYIAAQWSD
YGPSASTYLE VYYAWRDGLP ALADKAWGGN LSEAEYNSIL EKVIANIPGQ NLDRRVKSKT
DLILDYRFSD ARASKSKLVR DTSGNGYDAV NHNCKIRRSE VLVSSRCYLE TPLSSKGRDY
TLSFWVYPES RRHGELFSGP DSALHLGYGT SPNVTLVSGN HAYSLNYSLP TNIWTHVDLS
ARGGSTFLKV FEKNAAKTME FLAEVKPNGV MGSNGVMTIW RPIAIEAPLR RIGRGFVGKM
RSISLRGTA
//
