ID N4UQ77_FUSC1 Unreviewed; 598 AA.
AC N4UQ77;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Manganese lipoxygenase {ECO:0000256|ARBA:ARBA00021175};
DE EC=1.13.11.45 {ECO:0000256|ARBA:ARBA00013178};
GN ORFNames=FOC1_g10004503 {ECO:0000313|EMBL:ENH72265.1};
OS Fusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1229664 {ECO:0000313|EMBL:ENH72265.1, ECO:0000313|Proteomes:UP000016928};
RN [1] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-
CC octadecadienoate; Xref=Rhea:RHEA:18993, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:30245, ChEBI:CHEBI:57467; EC=1.13.11.45;
CC Evidence={ECO:0000256|ARBA:ARBA00000366};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; KB730103; ENH72265.1; -; Genomic_DNA.
DR AlphaFoldDB; N4UQ77; -.
DR STRING; 1229664.N4UQ77; -.
DR VEuPathDB; FungiDB:FOC1_g10004503; -.
DR HOGENOM; CLU_004282_4_0_1; -.
DR OMA; MMFNAND; -.
DR Proteomes; UP000016928; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0050584; F:linoleate 11-lipoxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043651; P:linoleic acid metabolic process; IEA:UniProt.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF153; LIPOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016928};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..598
FT /note="Manganese lipoxygenase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004122085"
FT DOMAIN 229..564
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
SQ SEQUENCE 598 AA; 66502 MW; DC79C66B253A2FC8 CRC64;
MRLNIALLFN VAGAIATTNR PRPFSLPSSN ASGRAAAIEK TRQGFQYGTD DTLIGVNPWP
SGPLGKKAVK AHYSAFETSE APVYKHVEED AAHAQASLNG TLHLDSFEDY LKLYDGQWQN
SVPDGLAEGV LRNAKSDLSF SMERLSVHPE SLRRVRPDER VSLRVEDKLA RKITTKTQRS
LQKEGRLFIV DHSSLANLTL TKGRYAGACE ALFFIHPTTG EFLPLAIPHI SSDLIYMSAT
RSFSDMHPVW GLVRRLGVNS FAYRVGASTS LVNPGGDIEK NFAWNGDQAI KYSKQVWHSE
CAPWQANYLE TKLKRRGLIN CDYGPELESF PYYEDASVIL DALRTFITAY IDAYYPSDDA
IVADNELLAW FNEAANVASI VDFPDSITTK SELVAVLSHH AYLISILHGS LNSNSLVHYS
AVLPMHPLSL YQPLPKDKGT SSLVSFLPDL EASIQQIALV TAFNQAQLAG TTDSLLFLFD
EPEFHSRINK EARAAAKVYS ATLSKFSEDV KARKLDGNSY SQIRHPESLP PRILSSRTRR
CYVTTPSSAP SAYPFMLSFA SINLGLPVRK HIMLKEQLGF RTTRLLCYCH AIQEKRTC
//
