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Database: UniProt
Entry: N4UQA8_COLOR
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Original site: N4UQA8_COLOR 
ID   N4UQA8_COLOR            Unreviewed;       521 AA.
AC   N4UQA8;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   31-JUL-2019, entry version 36.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|PIRNR:PIRNR000909, ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|PIRNR:PIRNR000909, ECO:0000256|RuleBase:RU004273};
GN   Name=pzh1 {ECO:0000313|EMBL:TDZ20619.1};
GN   ORFNames=Cob_13416 {ECO:0000313|EMBL:ENH77404.1}, Cob_v006752
GN   {ECO:0000313|EMBL:TDZ20619.1};
OS   Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 /
OS   LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum
OS   lagenarium).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Glomerellales; Glomerellaceae;
OC   Colletotrichum.
OX   NCBI_TaxID=1213857 {ECO:0000313|EMBL:ENH77404.1};
RN   [1] {ECO:0000313|EMBL:ENH77404.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MAFF 240422 {ECO:0000313|EMBL:ENH77404.1};
RA   Gan P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA   Takano Y., Kubo Y., Shirasu K.;
RT   "Genome analysis of Colletotrichum orbiculare and Colletotrichum
RT   gloeosporioides.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000014480}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422
RC   {ECO:0000313|Proteomes:UP000014480};
RX   PubMed=23252678; DOI=10.1111/nph.12085;
RA   Gan P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA   Takano Y., Kubo Y., Shirasu K.;
RT   "Comparative genomic and transcriptomic analyses reveal the
RT   hemibiotrophic stage shift of Colletotrichum fungi.";
RL   New Phytol. 197:1236-1249(2013).
RN   [3] {ECO:0000313|EMBL:TDZ20619.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=104-T {ECO:0000313|EMBL:TDZ20619.1};
RA   Gan P., Shirasu K.;
RT   "Hybrid genome sequence and assembly of Colletotrichum orbiculare.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000014480}
RP   GENOME REANNOTATION.
RC   STRAIN=104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422
RC   {ECO:0000313|Proteomes:UP000014480};
RX   PubMed=30893003; DOI=10.1094/MPMI-12-18-0352-A;
RA   Gan P., Tsushima A., Narusaka M., Narusaka Y., Takano Y., Kubo Y.,
RA   Shirasu K.;
RT   "Genome sequence resources for four phytopathogenic fungi from the
RT   Colletotrichum orbiculare species complex.";
RL   Mol. Plant Microbe Interact. 0:0-0(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;
CC         Evidence={ECO:0000256|SAAS:SAAS01116782};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-
CC         [protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-
CC         COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977;
CC         EC=3.1.3.16; Evidence={ECO:0000256|PIRNR:PIRNR000909,
CC         ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS01116780};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000909};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-Z subfamily.
CC       {ECO:0000256|PIRNR:PIRNR000909}.
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DR   EMBL; KB726094; ENH77404.1; -; Genomic_DNA.
DR   EMBL; AMCV02000017; TDZ20619.1; -; Genomic_DNA.
DR   STRING; 5465.ENH77404; -.
DR   EnsemblFungi; ENH77404; ENH77404; Cob_13416.
DR   OrthoDB; 766640at2759; -.
DR   Proteomes; UP000014480; Unassembled WGS sequence.
DR   GO; GO:0000324; C:fungal-type vacuole; IEA:EnsemblFungi.
DR   GO; GO:0048037; F:cofactor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004724; F:magnesium-dependent protein serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR011159; PPPtase_PPZ/Ppq1.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   InterPro; IPR031675; STPPase_N.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF16891; STPPase_N; 1.
DR   PIRSF; PIRSF000909; PPPtase_PPZ; 2.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000014480};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR000909,
KW   ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS01017252};
KW   Manganese {ECO:0000256|PIRNR:PIRNR000909,
KW   ECO:0000256|SAAS:SAAS01017251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000909,
KW   ECO:0000256|SAAS:SAAS01017255};
KW   Protein phosphatase {ECO:0000256|PIRNR:PIRNR000909,
KW   ECO:0000256|SAAS:SAAS01017274};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014480}.
FT   DOMAIN      311    316       SER_THR_PHOSPHATASE.
FT                                {ECO:0000259|PROSITE:PS00125}.
FT   REGION        1    154       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      499    521       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS     47    102       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    111    125       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   521 AA;  56789 MW;  62B7E67D47AB6A51 CRC64;
     MGNQPSKEGG HASGKGAGGE RTAEDLKSYP SFNRSDTKES SRSFKALRSK IPGSSKTDSP
     RNSVVASPAD ENPDSASVKS GKSRGRNDSA SSPTSPTGDL ESPLDDSQPP PSPTQSSTIK
     SGHHDVSAAQ ASGEVDHVSD QPPCAGGSLN THMQQPGKSI LSKVLDGAAM PVAKASSTNS
     SDKTEGGVAM SDIKDIDLDD FIKRLLDAGY AGKVTKSVCL KNAEIVAICQ RAREVLLSQP
     ALLELDAPVK IVGDVHGQYT DLIRMFEMCG FPPSSNYLFL GDYVDRGKQS LETILLLLCY
     KLKFPNNFFL LRGNHECANV TRVYGFYDEC KRRCNVKIWK TFIDCFNTLP IAAIVAGKIF
     CVHGGLSPAL SHMDDIRNIA RPTDVPDYGL LNDLLWSDPA DVEQDWEANE RGVSYCFGKR
     VILDFLARHD FDLICRAHMV VEDGYEFFND RVLVTVFSAP NYCGEFDNWG AVMSVSNELL
     CSFELLKPLD SSALKSHIKK GRNKRQSMLN SPPAYVEPRS V
//
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