ID N4URU4_FUSC1 Unreviewed; 1335 AA.
AC N4URU4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=FOC1_g10009588 {ECO:0000313|EMBL:ENH72850.1};
OS Fusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1229664 {ECO:0000313|EMBL:ENH72850.1, ECO:0000313|Proteomes:UP000016928};
RN [1] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RA Fang X., Huang J.;
RT "Genome sequencing and comparative transcriptomics of race 1 and race 4 of
RT banana pathogen: Fusarium oxysporum f. sp. cubense.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000016928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 1 {ECO:0000313|Proteomes:UP000016928};
RX PubMed=24743270;
RA Guo L., Han L., Yang L., Zeng H., Fan D., Zhu Y., Feng Y., Wang G.,
RA Peng C., Jiang X., Zhou D., Ni P., Liang C., Liu L., Wang J., Mao C.,
RA Fang X., Peng M., Huang J.;
RT "Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium
RT oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease.";
RL PLoS ONE 9:E95543-E95543(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; KB730092; ENH72850.1; -; Genomic_DNA.
DR STRING; 1229664.N4URU4; -.
DR VEuPathDB; FungiDB:FOC1_g10009588; -.
DR HOGENOM; CLU_003836_2_0_1; -.
DR OMA; LYRPKYG; -.
DR Proteomes; UP000016928; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd04712; BAH_DCM_I; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF54; DNA METHYLTRANSFERASE DIM-2; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016928};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 510..640
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 80..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..95
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1303..1335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 885
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1335 AA; 150213 MW; D9562D1E196F767A CRC64;
MPHIDLDEND VVDLTLDEFQ NEDNVIDLTL QNFENPDIDW LSNHNDDFDG VFGDAFAPRE
PHTTATTTHD TPKMWTKFGE MEEEEEEEEE EDGMSVMERV DLSPSPPTQS PPNYGSSPET
LFEDIYPEMP KLPESCVMIA ADPDLEVGDA DEGASAEVVE QEDITMEETP DVPLSENMSV
ELPESLLLVP RSYYEPFEPG VPVLTECEAV ARLLEVAEEA GQGIDFDDFV EFQLNEFAVY
SDRQRYGQEM CSLHHLHTKH GFNTVFFDGK LSVGSTVFYV HSVEISALPI ENYGTLSKHT
VRDKIWVRSV LNSEREIYYR LNTPAKEYRR FFDPFLWVAD LAKHFVDYLK FKGEKDDQVT
IFHFRSNFSI WLAKMHRNAP DFISWKGQHI NDDFRAAIVA NVTFLHKEAI GVLGHRKTYK
HVIWAEVWEF TRYKLCPKIV PSEDADTVVT QYIYDCFSHQ PFGHRLKAIP LSETTQSLRN
ALIKQRHLEL PAPVHDSAKT MTMAGQKQIR AIRAGDTIST QRDAEGSGTQ WRRDVAHGFD
DVDRWFALVQ RVRVNKRGQR TFDVIWYYRP VDTLCGLMKY PWNNELFLSD HCSCDTRAKI
SEDEVSGVHE VEFGGTSATK AEFFCRQTYI CVERNWVTLE KDHFRCIHLR ESSPQALGFR
AGETRLVMIN KTSGRSEPCE FLTFYEEEGN GIYRFRKLLR RHQVDPVSKA RPNGLVYSYV
EPLVEVKSSR ILEPCFVRYF KDGETIPTPY DRDGVGGFFY FTHEQVSDNE TGMKSYVALS
EPPSSIQQGY DPSQSIPRLR GLDLFCGGGN FGRGLEDGGA IEMRWANDFD AKAIHTYMAN
TAGPSEVSPF LGSIDDLQRL AIEGEFSDSV PPIGDVDFIS GGSPCPGFSR LTNDKTTAAQ
RKNQSLVAAF ASCVDLYRPR YGLLENVPGI VQKTANRDQD VFSQLICAIV GLGYQAHFFF
LDASACGSPQ RRSRVFLAFA APGHRLPHKP YQTHAHPQNT SRLSLGILPT GEPMAERAMP
AATPFDFVSA RASTADLPPI YDSKPDICVP YPDHRVSVGI TPLMRSRIHL IPTQPWGMNY
AQAWYGRDLK KAGSGVMTPS ERLAFPERTD QGLGRANPNS NAYGRQRPDH LFVTIVKTQS
PDDAKNGRTL HWREPRALTI MEARRAQGFR DDEVLLGIPS DQYKIVGNSV AREVAVSLGA
VFCEAWIQSL ADEHHVQSGD HASTAVVPSV APARMGVEVS PITNIRRLES ESASVESTPR
SRKSRSESRV NQVSSTVSST PPTPPQSSTK HSRIAVNIRG SKSLRTDEYN SPSRATSTAS
SRSKSSRLRH STTGE
//
