ID N4V7Q0_COLOR Unreviewed; 883 AA.
AC N4V7Q0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Ergothioneine biosynthesis protein 1 {ECO:0000313|EMBL:TDZ14452.1};
GN Name=egt-1-1 {ECO:0000313|EMBL:TDZ14452.1};
GN ORFNames=Cob_v012625 {ECO:0000313|EMBL:TDZ14452.1};
OS Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS
OS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum
OS lagenarium).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum orbiculare species complex.
OX NCBI_TaxID=1213857 {ECO:0000313|EMBL:TDZ14452.1, ECO:0000313|Proteomes:UP000014480};
RN [1] {ECO:0000313|Proteomes:UP000014480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422
RC {ECO:0000313|Proteomes:UP000014480};
RX PubMed=23252678; DOI=10.1111/nph.12085;
RA Gan P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Comparative genomic and transcriptomic analyses reveal the hemibiotrophic
RT stage shift of Colletotrichum fungi.";
RL New Phytol. 197:1236-1249(2013).
RN [2] {ECO:0000313|Proteomes:UP000014480}
RP GENOME REANNOTATION.
RC STRAIN=104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422
RC {ECO:0000313|Proteomes:UP000014480};
RX PubMed=30893003; DOI=10.1094/MPMI-12-18-0352-A;
RA Gan P., Tsushima A., Narusaka M., Narusaka Y., Takano Y., Kubo Y.,
RA Shirasu K.;
RT "Genome sequence resources for four phytopathogenic fungi from the
RT Colletotrichum orbiculare species complex.";
RL Mol. Plant Microbe Interact. 32:1088-1090(2019).
CC -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00037882}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TDZ14452.1}.
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DR EMBL; AMCV02000050; TDZ14452.1; -; Genomic_DNA.
DR AlphaFoldDB; N4V7Q0; -.
DR STRING; 1213857.N4V7Q0; -.
DR EnsemblFungi; ENH83409; ENH83409; Cob_08257.
DR eggNOG; ENOG502QS9T; Eukaryota.
DR HOGENOM; CLU_006921_0_1_1; -.
DR OrthoDB; 1416at2759; -.
DR Proteomes; UP000014480; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR024775; DinB-like.
DR InterPro; IPR019257; MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR017805; SAM_MeTrfase_EasF-type_put.
DR InterPro; IPR005532; SUMF_dom.
DR InterPro; IPR042095; SUMF_sf.
DR NCBIfam; TIGR03439; methyl_EasF; 1.
DR PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR Pfam; PF12867; DinB_2; 1.
DR Pfam; PF03781; FGE-sulfatase; 2.
DR Pfam; PF10017; Methyltransf_33; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000014480};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 58..343
FT /note="Histidine-specific methyltransferase SAM-dependent"
FT /evidence="ECO:0000259|Pfam:PF10017"
FT DOMAIN 389..515
FT /note="DinB-like"
FT /evidence="ECO:0000259|Pfam:PF12867"
FT DOMAIN 572..719
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
FT DOMAIN 786..880
FT /note="Sulfatase-modifying factor enzyme"
FT /evidence="ECO:0000259|Pfam:PF03781"
SQ SEQUENCE 883 AA; 99608 MW; CB7684454F947C50 CRC64;
MGSIAVSQDG FAGVDIRSKQ QQKTTPVGSR EVDIIDIQRV AVETNLKDDI IAMWNPTNGP
RKLPTLLLYN ERGLQLFEDI TYLEEYYLTN NEIEVLQNYS KEIAQNIAPE SMVIELGSGN
LRKVSLLLQA FEDAGKPIDY YALDLSLEEL ERTLAQVPKF QHVRCHGLLG TYDDGREWLK
KPENLARKKC ILSLGSSIGN FERYDAAGFL KHFSDALSPA DTMLIGLDGC CDPAKVYHAY
NDKHGVTHRF ILNGLENANE ILGEEAFKLE DWEVIGEYVY DEEGGRHQAF YSPVRDTYVM
GTLIQQHERI QVEQSLKYSQ LGAENLWNQA GLIETACWSK GDEHGIHLIS KRKMPFSLLP
DLYAASPCPS TEDWKAMWTA WDTVTQSMLP GEELHDKPIK LRNACIFYLG HIPAFLDIQL
TKTTKTTKTG PTEPRHFQPM FERGIDPDVD NPEKCHSHSE IPDEWPRVEE ILEYQQRVRA
RLLDLYKDGI DRIPRSVAQG IWVGFEHEAM HMETLLYMML QSDKTLPPPE VERPDFRRLA
DKARVSRVPN EWHDVPAQSV TIGMDEPDLD AGVNAYFGWD NEKPARKADV HAFQAKGRPI
TNEEYAHYMF ENHIERVPAS WADVTDDDAP KINGHTNGLS NGHTNGHVNG HTDGTTNGHT
NGHNGVGQLP DSFLNGMAVR TVFGLVPLKY ALDWPIFASY DELSGCAAWM GGRVPTLEEA
RSIYTYVHNT RKMEAEQTLG RTVPAVNGHL SNDGVEETPP RHVPLEAAKT RKDLFADLDG
ANVGFQHWHP VPVTADGGRL AGQGELGGVW EWTSSPLARH EGFEPMPLYP QYTTDFFDGK
HNIVLGGSWS THPLIAGRRS FVNWYQRNYP YAWAGARLVR DVN
//
