ID N4WKT5_9BACI Unreviewed; 573 AA.
AC N4WKT5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Pyruvate oxidase {ECO:0000313|EMBL:ENH96782.1};
DE EC=1.2.3.3 {ECO:0000313|EMBL:ENH96782.1};
GN ORFNames=J416_08784 {ECO:0000313|EMBL:ENH96782.1};
OS Gracilibacillus halophilus YIM-C55.5.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Gracilibacillus.
OX NCBI_TaxID=1308866 {ECO:0000313|EMBL:ENH96782.1, ECO:0000313|Proteomes:UP000012283};
RN [1] {ECO:0000313|EMBL:ENH96782.1, ECO:0000313|Proteomes:UP000012283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM-C55.5 {ECO:0000313|EMBL:ENH96782.1,
RC ECO:0000313|Proteomes:UP000012283};
RA Sugumar T., Polireddy D.R., Antony A., Madhava Y.R., Sivakumar N.;
RT "Draft genome sequence of Gracibacillus halophilus YIM-C55.5, a moderately
RT halophilic and thermophilic organism from the Xiaochaidamu salt lake.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENH96782.1}.
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DR EMBL; APML01000030; ENH96782.1; -; Genomic_DNA.
DR RefSeq; WP_003468501.1; NZ_APML01000030.1.
DR AlphaFoldDB; N4WKT5; -.
DR STRING; 1308866.J416_08784; -.
DR PATRIC; fig|1308866.3.peg.1778; -.
DR eggNOG; COG0028; Bacteria.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000012283; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0047112; F:pyruvate oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:ENH96782.1};
KW Pyruvate {ECO:0000313|EMBL:ENH96782.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000012283};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 6..119
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 193..319
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 381..526
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 573 AA; 63585 MW; 1FEACB650B714218 CRC64;
MFEKRTGNIL VDQLVEAGVD HIYGMPGNSI NQFIEDLRRK EDEMDFIQVR HEEIGALAAS
SYAKLTGKLG VCLSIAGPGA THLINGLYDA KKDFAPVLAI VGQVPSTEVG TDSHQEINLE
RMFDGVAVFN KRAESAEQLP DMLHMAIREA YIYKGVSVLI VPDDLFTVKQ DREVMTTSKT
IAEPVITPNQ ETIDQAAQLL NQAEKPVILA GKGARHARTE LIEFAEKLQA PVVLSLLGKG
TIPDYHELNL GQHGQIGTKP AFEAVMETDL LIIIGTTFPY RDYLPDHVHA IQIEIKQDHL
GKFYPITAGL CGDSKEVLPI LTKAVKSGRS DAFLNQYKEK MKQWHIHAQE IKQDDSDPIH
GPQIMYALEK CVEKDAIISC DVGNVTVWTS RFFPFTNQHF IISGGLASMG SGLPGAIAAQ
KAYPDRQVVG ICGDGGFTMV MQDFITAVKY QMPVKMVVLN NSMIGMIKYE QQTKGNLNYE
TELEGIDFAE FARACGGEGF RIEKYSEMED KMKQAFLSDQ PAVIDVVMED MAPLPGKITY
DQAVKYGEYL IKEFFSNGNI EFPDVGKTMK RLF
//