ID N6T077_DENPD Unreviewed; 346 AA.
AC N6T077;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Suppressor of cytokine signaling 7 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN Name=109544781 {ECO:0000313|EnsemblMetazoa:ENN70913};
GN ORFNames=D910_05599 {ECO:0000313|EMBL:ERL88211.1}, YQE_12316
GN {ECO:0000313|EMBL:ENN70913.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN70913.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN70913}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APGK01057453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741280; ENN70913.1; -; Genomic_DNA.
DR EMBL; KB632033; ERL88211.1; -; Genomic_DNA.
DR RefSeq; XP_019770674.1; XM_019915115.1.
DR AlphaFoldDB; N6T077; -.
DR STRING; 77166.N6T077; -.
DR EnsemblMetazoa; ENN70913; ENN70913; YQE_12316.
DR GeneID; 109544781; -.
DR KEGG; dpa:109544781; -.
DR HOGENOM; CLU_802317_0_0_1; -.
DR OrthoDB; 5401079at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd03717; SOCS_SOCS_like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 197..301
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 296..346
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 137..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN70913.1"
SQ SEQUENCE 346 AA; 39800 MW; 2C4A5F248E72D046 CRC64;
MDSHSDNRTR SWLFRLKYLK VFKNSNNSNS TSDKNQICAA RNTANGAFTQ STTRNNLNDS
TDLRRSETHL RKSIKKWHNR MKNCFWKNNR HLTSRPPIYI AHQPDSPSFS RRSNSDTFQT
ENIYTLDPSV QRKITVAVSE QQSHSNKSSN ISLDSSSSRL STTADIQPRS SHLTNANPSG
CNYTPKNEVS SLAHQVWYWG PVSKSLVEAK LEGAPDGSFL VRDSASDRHI FSISFRSVGK
TLHSRIEHTN SGFRVFDHKC FDTVRELIEQ AVKISSEEQV FCYTKSQGME PNYPVRLLKP
ISRYDEVRSL QSLSRFVIRQ HINVNDIENL CLPVTLIQYL REENYF
//
