ID N6T8M3_DENPD Unreviewed; 594 AA.
AC N6T8M3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ENN76564.1, ECO:0000313|EnsemblMetazoa:ENN76564};
DE Flags: Fragment;
GN Name=109538316 {ECO:0000313|EnsemblMetazoa:ENN76564};
GN ORFNames=D910_08351 {ECO:0000313|EMBL:ERL91009.1}, YQE_07014
GN {ECO:0000313|EMBL:ENN76564.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN76564.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN76564}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- FUNCTION: Ubiquitin-binding protein that specifically recognizes and
CC binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked
CC ubiquitin. Positively regulates the internalization of ligand-activated
CC EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell
CC membrane. {ECO:0000256|ARBA:ARBA00024956}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; APGK01040123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740975; ENN76564.1; -; Genomic_DNA.
DR EMBL; KB632267; ERL91009.1; -; Genomic_DNA.
DR RefSeq; XP_019761052.1; XM_019905493.1.
DR AlphaFoldDB; N6T8M3; -.
DR STRING; 77166.N6T8M3; -.
DR EnsemblMetazoa; ENN76564; ENN76564; YQE_07014.
DR GeneID; 109538316; -.
DR KEGG; dpa:109538316; -.
DR HOGENOM; CLU_026137_2_0_1; -.
DR OMA; PKRITAK; -.
DR OrthoDB; 20116at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 6.10.140.100; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR021832; ANKRD13.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR12447; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13; 1.
DR PANTHER; PTHR12447:SF31; LD31969P; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF11904; GPCR_chapero_1; 1.
DR Pfam; PF02809; UIM; 4.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00726; UIM; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50330; UIM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT REPEAT 42..74
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN76564.1"
SQ SEQUENCE 594 AA; 68106 MW; 6C131459DD3327F4 CRC64;
MVSEEFIKKE YPLHWLVWKN EFKLLEKALK ENKSDKEKAD NRGRTPLMLA VTLGHLESTR
SLLNHEANVN CENKNGWNVV QEAVATGDPE LLHIVLERRD LQRYTSRMAG IPDLLHKLKE
APDFYVEMKW EFTSWVPLVS RMCPSDTYKV YKQGSNVRID TTLLGFDHTS WQRGNRSYVF
QDQNGSATVM EIDHDLRQVY CEEMRSSDDT LGVLMPNEET VSHRLTNPIV TTYVDTEKIS
FERNKAGIWG WRSDKNEGVN GYDCKVFGAS NVELVTKTRS EHLTEHDKAR SKNLRTPLQS
FLGIAEVGSS QSSSEIPKEE YTNNTNPCNI LPEEYFDPQV DLGDRDIGRP KEVNVKVQKF
KANLWLCEDY PLSLPEQILP IVDLMAISSS HFAKLKDFIQ MQLPSGFPVK IEIPLFHVLN
ARITFGNIFA LDSPVPKVST LEEDDRLTCV LDETLFQCPP TYIQIGNAAS DGRRQFNSEE
EDDLLQFAIQ QSLVESGTEK EEVDIWEALR GHKPSRPETP VNVEERELQR AIEASLEQYQ
GPPSDAQNSP SSDLDYDLQM ALMVSRKERE KEEQNRIDEE KMLEQALQLS LTEK
//
