ID N6TE97_DENPD Unreviewed; 1644 AA.
AC N6TE97;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN Name=109535759 {ECO:0000313|EnsemblMetazoa:ENN78679};
GN ORFNames=D910_12501 {ECO:0000313|EMBL:ERL95234.1}, YQE_04851
GN {ECO:0000313|EMBL:ENN78679.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN78679.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN78679}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
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DR EMBL; APGK01032712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740848; ENN78679.1; -; Genomic_DNA.
DR EMBL; KB632411; ERL95234.1; -; Genomic_DNA.
DR RefSeq; XP_019757296.1; XM_019901737.1.
DR STRING; 77166.N6TE97; -.
DR EnsemblMetazoa; ENN78679; ENN78679; YQE_04851.
DR GeneID; 109535759; -.
DR KEGG; dpa:109535759; -.
DR HOGENOM; CLU_004268_0_0_1; -.
DR OMA; MRNSFGG; -.
DR OrthoDB; 5405671at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22207; pseudoGTPaseD_p190RhoGAP; 1.
DR Gene3D; 1.10.10.440; FF domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF4; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 1.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 429..483
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 596..775
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 782..942
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1431..1635
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 948..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1381..1419
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1191..1224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN78679.1"
SQ SEQUENCE 1644 AA; 187793 MW; E86E1C3DA2954337 CRC64;
MARKGETIRS INVSIVGLSG VEKDKGHAGI GKSCLCNRFI RPYAEDYYID HISVLSQTDF
SGRVVNNDHF LYWGDAIKSL DDGTDYQFSL IEQTEFIDDA SFQPFKGGKM EPYVKRCTAT
KISSAEKLMY ICKNQLGIEK EYEQKVLPDG RMNIDGFICI FDVSVVPSRS IEKQIEFCAA
ILNNILKTKK PVVMITTKND ESHDVYVREA HKLVQRSEYK GNIPLVESSA HENVNIDLGF
LLLAQIIEKT KVRLKIPSYG EAALARKEMM DVASETFMRL IRVHVTDCHG LWSQTQKKLN
NHKEWIHFVQ LFGLDGTQRL FKRHIKKLKD ENMAKQVAKY MEMLPDVLHD LIPGYNTLQD
TDWQSIQQYI KNHPNFSQYF FERPEDIPWT ECVGSDSDET RIPFDVLDTS DAETIFRNHI
NVLQQEQKRL EYKKQFKQLL EDTGYVTPGK HLSEVRVLFM GRECFEALTE HDCQQIYDAH
QRELIETAKH NFQELLLEHA DLFYHFKSIA PTGTITQDDI KEITDTLQED FRYKILDRLD
QDRKLTLFQH LGFIHYPIRE HCPAFPNCMD SLIERILATK AHRPSSWNHS NQWLMSSENN
QLNLLILGLD NLADNLAAKI RAQCDDDEYE IDCQFYSLDY RIINGDVSLP HNSFKTSEFV
PHGSFCVYSN AESFEYIRES LEKKLLSNLE QDDKLPFQGL PIVLMYLQDS TTEDKEVLKL
KEDGQNLADS LQCPFMDVSL DQIGEEQLVS DALQQLVQSI HHRAGFLNIN QSVIECVEPD
IRVIMCMFCG DPYSVENVLS PLLNHQFCFL SSPHSVILET FLGDSKRKVE VIVSSFHGAN
AFRDELVHGF ILVYSTKRKA SLATLNAFSM NIPNLPIQIL AVTDSGSATA FFNDDMSQML
ITEGNSTADR LGAHFMTSSA AMQPKTAFFT PFFKEVWEKK PEIEQAFHME EPSGLDSGEG
TLERSRSTGR HGPMPPPRNE SYYLKLGNEG SESENFDLSG PDDKLSSSDH SDRFSSIYMY
GSEGSMGKKR HNHSGLQVYP PPATPPEPAP PDNIGSRYSK KSLMSSQTSL DEVHYGDPPM
SLPGSAWNNY QQHAFTTGRR HMPVSKSRSK GISQTLKQPG KLNMKNYSAV TEAIARMNMN
DSSFGNAPLA TPEPVDLGCE YAQVKDMVHN MYPPESEYMY TMVQDAISGK TKLRQRREKG
QPSYSDSDSE WSSLERRQRA SEVYSKVTRK GGTHKRQRKK RTAIPVQPPR VPQLGPFTMP
SMHSPSVEGE EKANVATESN SESSEVSETE QFPPANMADI RMKFAQKRSQ SLKKRIPDLP
NSHNFNMLNS LDLYTGQANS YGMMHDEESS LDVSSPRDNN SPMFGVFPRM KETDLEKLLR
KREKQKAKDD SKLEKRRLKE EKLRKVAEEK DRKRQLKTNK KAAVLPSGVP SKLTDYIQSD
KNYIPIFMEK CVKFIEAEGL DSEGIYRVPG NRAHVDLLFL KFEEDVNVDI HELDIPVNAV
ATALKDFVSK RLPPLFDENV LAEMEEIAGT RMKPMVTTTG NMEVKADRSC RLLALRQMLD
KLPPINFAIL KFVFQHFVKI TENSKLNSMD SKNLAICWWP TLLPIEFSDM GRFEQMRPYL
EDIVQTMIDQ YPFLFCGKEA FVMV
//
