ID N6TH77_DENPD Unreviewed; 724 AA.
AC N6TH77;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
DE Flags: Fragment;
GN Name=109534540 {ECO:0000313|EnsemblMetazoa:ENN79789};
GN ORFNames=D910_00760 {ECO:0000313|EMBL:ERL83626.1}, D910_02940
GN {ECO:0000313|EMBL:ERL85521.1}, D910_06480
GN {ECO:0000313|EMBL:ERL89103.1}, YQE_03845
GN {ECO:0000313|EMBL:ENN79789.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN79789.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN79789}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|ARBA:ARBA00006459,
CC ECO:0000256|RuleBase:RU003732}.
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DR EMBL; APGK01027141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01027142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740648; ENN79789.1; -; Genomic_DNA.
DR EMBL; KB630489; ERL83626.1; -; Genomic_DNA.
DR EMBL; KB631709; ERL85521.1; -; Genomic_DNA.
DR EMBL; KB632148; ERL89103.1; -; Genomic_DNA.
DR RefSeq; XP_019755833.1; XM_019900274.1.
DR AlphaFoldDB; N6TH77; -.
DR EnsemblMetazoa; ENN79789; ENN79789; YQE_03845.
DR GeneID; 109534540; -.
DR KEGG; dpa:109534540; -.
DR HOGENOM; CLU_006855_9_0_1; -.
DR OMA; HHQPLYG; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd10332; SLC6sbd-B0AT-like; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR PANTHER; PTHR11616:SF305; TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN79789.1"
SQ SEQUENCE 724 AA; 80457 MW; 5993642337E5AA3D CRC64;
MANTAHFVRR QSSRDLHSQR SIDRLELKEM KGRLVPIENG SSSAYGATNI AFEDTSPGTK
IKSTCSSKRG SQDGKGIFKP DCEEEDRESW DSKLTFLLAT VGYAVGLGNV WRFPYLAQKN
GGGAFLIPYF VMLAIEGIPI FYLELAIGQR LRKGAIGVWN QVSPFLAGIG ISSAVVSFNV
ALYYNTIIAW CLFYFLQSFQ SQLPWAECPN VYFPNGSYTQ ETECVASSPT QFFWYRTTLM
ISEDVNTPEA FNWKIALALV VAWILVYLCM IKGIASSGKV VYVTATFPYI VLIIFFFRGI
TLKGASDGLR HLFTPSWHII LDPVVWLEAG TQIFFSLGLA FGGLIAFSSY NPVNNNCYRD
AIMVSMTNCF TSMFAGIVVF SIIGFKATMT YEKCLDDKNK TLSSLLGENY DPQLILPEAG
SIFNFSDENG ALKSIIVPVL QVCDLQKELD NSASGTGLAF IIFTEAINQF PGAQFWSILF
FLMLFTLGID SQFGTLEGVV TSIVDMKLFP NLPKEILTGV LCLICCIISM SFAHGAGSYV
FVLFDNFSGN FPLLIIAFFE CIGVSYVYGL KRFADDIEMM TGSRPGLYWL ICWKYLSPLA
MISILAASFI EIAVEGSGYD AWVSEKGITE KHPWPMWAIF LICSLILVSI LWIPGVAIAR
CFGYVLIDDN EKAWFPASDL KDFHGIMPHE ITTAETLLFC IRADGSEGLC CPTYHSYDDV
IDDD
//
