ID N6TII1_DENPD Unreviewed; 566 AA.
AC N6TII1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) {ECO:0000256|ARBA:ARBA00012728};
DE EC=5.4.2.2 {ECO:0000256|ARBA:ARBA00012728};
DE Flags: Fragment;
GN Name=109536999 {ECO:0000313|EnsemblMetazoa:ENN77623};
GN ORFNames=D910_07601 {ECO:0000313|EMBL:ERL90249.1}, YQE_05917
GN {ECO:0000313|EMBL:ENN77623.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN77623.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN77623}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate;
CC Xref=Rhea:RHEA:23536, ChEBI:CHEBI:58225, ChEBI:CHEBI:58601;
CC EC=5.4.2.2; Evidence={ECO:0000256|ARBA:ARBA00000443};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the phosphohexose mutase family.
CC {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|RuleBase:RU004326}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; APGK01036673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740941; ENN77623.1; -; Genomic_DNA.
DR EMBL; KB632225; ERL90249.1; -; Genomic_DNA.
DR RefSeq; XP_019759060.1; XM_019903501.1.
DR AlphaFoldDB; N6TII1; -.
DR STRING; 77166.N6TII1; -.
DR EnsemblMetazoa; ENN77623; ENN77623; YQE_05917.
DR GeneID; 109536999; -.
DR KEGG; dpa:109536999; -.
DR HOGENOM; CLU_009330_0_1_1; -.
DR OMA; WIQDRAN; -.
DR OrthoDB; 5476118at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004614; F:phosphoglucomutase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03085; PGM1; 1.
DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3.
DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1.
DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III.
DR InterPro; IPR036900; A-D-PHexomutase_C_sf.
DR InterPro; IPR016066; A-D-PHexomutase_CS.
DR InterPro; IPR005841; Alpha-D-phosphohexomutase_SF.
DR InterPro; IPR045244; PGM.
DR PANTHER; PTHR22573:SF2; PHOSPHOGLUCOMUTASE; 1.
DR PANTHER; PTHR22573; PHOSPHOHEXOMUTASE FAMILY MEMBER; 1.
DR Pfam; PF02878; PGM_PMM_I; 1.
DR Pfam; PF02879; PGM_PMM_II; 1.
DR Pfam; PF02880; PGM_PMM_III; 1.
DR PRINTS; PR00509; PGMPMM.
DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1.
DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 3.
DR PROSITE; PS00710; PGM_PMM; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|RuleBase:RU004326};
KW Metal-binding {ECO:0000256|RuleBase:RU004326};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 18..158
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02878"
FT DOMAIN 196..303
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02879"
FT DOMAIN 316..426
FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF02880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN77623.1"
SQ SEQUENCE 566 AA; 62438 MW; BDFDE0C4B9591D1E CRC64;
MSGTLESVIV PTTPFDDQKP GTSGLRKKVK VFMQKNYTEN FVQCILDALG EKLKGSTLVV
GGDGRYFSKP AINTIIRIAS ANEVSKLIIG QLGILSTPAV SALIRQEKVL GGIVLTASHN
PGGIRNDFGI KYNIENGGPA PDQITNTIYE LTKKITQYKT TPSLETDRII DVLGTRTFNV
EGRTFTVEII DSSKEYVALM KNIFDFHKLR ALIRGTDKRP AFHILLDSMN GVTGVYVRNI
FVEELGASPD NNVRRVVPLD NFGEIHPDPN LTYAKDLVNA LKADSSYDFG AAFDGDGDRN
MILGKNAFFV TPSDSLAVLA NNLECIPYFK KNGINGFARS MPTAAAVDRV AAKLGKEIFE
VPTGWKYFGN LMDAGRLSLC GEESFGTGSN HIREKDGLWA VLAWLSIIEH KNMGVEDILK
EHWKLYGRNY FTRYDYEECE TESANQLMQH LEALIADGSF VGKSFCSGGK SYTVAKADNF
SYVDPIDNSV ANNQGIRILF DDGSRLIYRL SGTGSSGATI RIYIECYEKE DVLTDAQIML
KPLVNIGLEI SQLKKFTGRE EPTVIT
//
