ID N6U1K2_DENPD Unreviewed; 351 AA.
AC N6U1K2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Cytoplasmic tRNA adenylyltransferase 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN Name=109539585 {ECO:0000313|EnsemblMetazoa:ENN75425};
GN ORFNames=D910_11434 {ECO:0000313|EMBL:ERL94152.1}, YQE_07976
GN {ECO:0000313|EMBL:ENN75425.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN75425.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN75425}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
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DR EMBL; APGK01043340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741014; ENN75425.1; -; Genomic_DNA.
DR EMBL; KB632381; ERL94152.1; -; Genomic_DNA.
DR RefSeq; XP_019762980.1; XM_019907421.1.
DR AlphaFoldDB; N6U1K2; -.
DR STRING; 77166.N6U1K2; -.
DR EnsemblMetazoa; ENN75425; ENN75425; YQE_07976.
DR GeneID; 109539585; -.
DR KEGG; dpa:109539585; -.
DR HOGENOM; CLU_026481_1_2_1; -.
DR OMA; KPVRGIC; -.
DR OrthoDB; 5483984at2759; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034227; P:tRNA thio-modification; IEA:InterPro.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR CDD; cd01993; Alpha_ANH_like_II; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_03053; CTU1; 1.
DR InterPro; IPR032442; CTU1_C.
DR InterPro; IPR000541; Ncs6/Tuc1/Ctu1.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR011063; TilS/TtcA_N.
DR InterPro; IPR035107; tRNA_thiolation_TtcA_Ctu1.
DR InterPro; IPR020554; UPF0021_CS.
DR NCBIfam; TIGR00269; TIGR00269 family protein; 1.
DR PANTHER; PTHR11807; ATPASES OF THE PP SUPERFAMILY-RELATED; 1.
DR PANTHER; PTHR11807:SF12; CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1; 1.
DR Pfam; PF01171; ATP_bind_3; 1.
DR Pfam; PF16503; zn-ribbon_14; 1.
DR PIRSF; PIRSF004976; ATPase_YdaO; 2.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR PROSITE; PS01263; UPF0021; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR004976-51};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR004976-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 52..228
FT /note="tRNA(Ile)-lysidine/2-thiocytidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01171"
FT DOMAIN 280..309
FT /note="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16503"
FT BINDING 55..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 61
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 87
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 165
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT BINDING 170
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR004976-51"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN75425.1"
SQ SEQUENCE 351 AA; 39303 MW; 78CBC0A04F5B34B1 CRC64;
MPACSTKCGK NAILKRPKTG DALCKTCFFE AFENEIHFTI ERAKLFRPGS TVAIGASGGK
DSTVLAYVLK LLNEKYNYQL KLVLLSIDEG ITGYRDDSLN TVKQNQEDYG MPLKIMSYKD
LYGWTMDEIV AEIGRKNNCT FCGVFRRQAL DRGANLLKVD YLATGHNADD IAETVLMNIL
RGDLARLNRC TSIITDCGDG IPRVKPLKYT FEKEIVMYAY FRKLVYFSTE CVFAPNAYRG
HARVLLKDLE KIDPTVIMNI IQSGETIKVN ETAKTPSLTR CTQCNYVSSQ EVCKACILLE
GLNKGLPRLG IGKSSKVKRL LKENEEKNKS CCRNDTQESA CICKANLPSI K
//
