ID N6U7Q2_DENPD Unreviewed; 300 AA.
AC N6U7Q2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=deoxyhypusine monooxygenase {ECO:0000256|ARBA:ARBA00012606};
DE EC=1.14.99.29 {ECO:0000256|ARBA:ARBA00012606};
DE Flags: Fragment;
GN Name=109536937 {ECO:0000313|EnsemblMetazoa:ENN77700};
GN ORFNames=D910_05813 {ECO:0000313|EMBL:ERL88427.1}, YQE_05772
GN {ECO:0000313|EMBL:ENN77700.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN77700.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN77700}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-
CC hypusine + A + H2O; Xref=Rhea:RHEA:14101, Rhea:RHEA-COMP:10144,
CC Rhea:RHEA-COMP:12592, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:82657,
CC ChEBI:CHEBI:91175; EC=1.14.99.29;
CC Evidence={ECO:0000256|ARBA:ARBA00000068};
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- PATHWAY: Protein modification; eIF5A hypusination.
CC {ECO:0000256|ARBA:ARBA00005041}.
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DR EMBL; APGK01036280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740939; ENN77700.1; -; Genomic_DNA.
DR EMBL; KB632061; ERL88427.1; -; Genomic_DNA.
DR RefSeq; XP_019758976.1; XM_019903417.1.
DR AlphaFoldDB; N6U7Q2; -.
DR STRING; 77166.N6U7Q2; -.
DR EnsemblMetazoa; ENN77700; ENN77700; YQE_05772.
DR GeneID; 109536937; -.
DR KEGG; dpa:109536937; -.
DR HOGENOM; CLU_053974_0_0_1; -.
DR OMA; GQLQEPC; -.
DR OrthoDB; 5474306at2759; -.
DR UniPathway; UPA00354; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0019135; F:deoxyhypusine monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR HAMAP; MF_03101; Deoxyhypusine_hydroxylase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027517; Deoxyhypusine_hydroxylase.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR PANTHER; PTHR12697:SF5; DEOXYHYPUSINE HYDROXYLASE; 1.
DR PANTHER; PTHR12697; PBS LYASE HEAT-LIKE PROTEIN; 1.
DR Pfam; PF13646; HEAT_2; 2.
DR SMART; SM00567; EZ_HEAT; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Hypusine biosynthesis {ECO:0000256|ARBA:ARBA00023256};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN77700.1"
SQ SEQUENCE 300 AA; 33622 MW; 3F16A000A4E07DFC CRC64;
MLNITDDQIR SIGDVLNNPS RPLKERFRAL FTLRNIGGPL AIASIEKCFA DESALLKHEL
AYCLGQMQDT AANPILVKVL KDEAEHPMVR HEAAEALGAI GSSDMVNILE RFKNDSSVEV
AETCQLALER INWLQSPDNS KCSENPYHSV DPAPPAQLKT VEELKGILIN DKESLFNRYR
AMFSLRNLRS KEAVEALGEG LKHGSALFKH EVAFVLGQLQ DESSVKYLQS SLENCDENEM
VRHECAEALG AIATEECMDI LNKYLRDDKR VVKESCEIAL DMCEYENSPE FQYANTLTVK
//
