ID N6UAI2_DENPD Unreviewed; 415 AA.
AC N6UAI2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
DE Flags: Fragment;
GN ORFNames=D910_11886 {ECO:0000313|EMBL:ERL94609.1}, YQE_07795
GN {ECO:0000313|EMBL:ENN75617.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN75617.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN75617}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR EMBL; APGK01042668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB741007; ENN75617.1; -; Genomic_DNA.
DR EMBL; KB632398; ERL94609.1; -; Genomic_DNA.
DR AlphaFoldDB; N6UAI2; -.
DR STRING; 77166.N6UAI2; -.
DR EnsemblMetazoa; ENN75617; ENN75617; YQE_07795.
DR HOGENOM; CLU_662710_0_0_1; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:UniProt.
DR GO; GO:0001654; P:eye development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211:SF40; HOMEOBOX PROTEIN ARAUCAN-RELATED; 1.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000030742}.
FT DOMAIN 92..174
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 94..175
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 181..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN75617.1"
SQ SEQUENCE 415 AA; 45102 MW; 21D5E4FD02BE36DE CRC64;
MDAPAFVSIS SSPLMGKNCQ CPMRIFCCPK STILFKQTEG SFIGRNNSNP YSLKDASGAA
DMSAWTSAGL QPTTGYYPYD PALAAYGYGA GYDLAARRKN ATRESTATLK AWLNEHKKNP
YPTKGEKIML AIITKMTLTQ VGFPLQLPAI ELIYATSFQV STWFANARRR LKKENKMTWE
PKNKTEDDDD ALVSDSDDKD KDDDDKRDDI DIHGRIKSER SNKDLEDDDM TDEDRKEDIL
GNSMHHILGN GYSLKAEIKN SDCGVPLPPS KPKIWSLADT AACKTPPPPP PAQGGQWLGS
SNGFALPSSR YNSNSGFLPS HCQQGFPEVQ TDTPPQTPPN MKLPTITGNV PAGQGAPCIG
AASNGGYSQN STSSFLGGFG RIHSPQRAQP ANGAQQMNAS SNVADNAAFK PFYKR
//
