ID N6UKG5_DENPD Unreviewed; 1259 AA.
AC N6UKG5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE Flags: Fragment;
GN ORFNames=D910_03692 {ECO:0000313|EMBL:ERL86283.1}, YQE_04356
GN {ECO:0000313|EMBL:ENN79172.1};
OS Dendroctonus ponderosae (Mountain pine beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Curculionidae; Scolytinae; Dendroctonus.
OX NCBI_TaxID=77166 {ECO:0000313|EMBL:ENN79172.1};
RN [1] {ECO:0000313|Proteomes:UP000019118, ECO:0000313|Proteomes:UP000030742}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23537049; DOI=10.1186/gb-2013-14-3-r27;
RA Keeling C.I., Yuen M.M., Liao N.Y., Roderick Docking T., Chan S.K.,
RA Taylor G.A., Palmquist D.L., Jackman S.D., Nguyen A., Li M., Henderson H.,
RA Janes J.K., Zhao Y., Pandoh P., Moore R., Sperling F.A., W Huber D.P.,
RA Birol I., Jones S.J., Bohlmann J.;
RT "Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins,
RT a major forest pest.";
RL Genome Biol. 14:R27-R27(2013).
RN [2] {ECO:0000313|EnsemblMetazoa:ENN79172}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; APGK01029511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01029512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01029513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01029514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01029515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; APGK01029516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB740735; ENN79172.1; -; Genomic_DNA.
DR EMBL; KB631805; ERL86283.1; -; Genomic_DNA.
DR AlphaFoldDB; N6UKG5; -.
DR EnsemblMetazoa; ENN79172; ENN79172; YQE_04356.
DR HOGENOM; CLU_001072_1_2_1; -.
DR OMA; CFDSTIE; -.
DR Proteomes; UP000019118; Unassembled WGS sequence.
DR Proteomes; UP000030742; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd14042; PK_GC-A_B; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF475; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000030742};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1259
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010839696"
FT DOMAIN 475..787
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 858..988
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ENN79172.1"
SQ SEQUENCE 1259 AA; 142420 MW; 59A1135FF577D321 CRC64;
MLKILLVMAS ITTKISSDNF TIGYLTGSQR RPGDREYSRP GLTISGAISL AVEEVNRTLA
KRGHQIYFIV EETFGEEIIS VQKTADLWTR NVSAYIGPQE TCEHEAFMAS AFNVPMISYV
VLLYLKSPEF EFINIATILK DTLPVFGITI IATKFWDSPY HHGYMDNPFV KLVEETYRDT
RIFVILGHHY EHLGLMIAME EKKLFDKGEY FVVGVDIEQY DDKNPSKYLR GLLRDSDFPN
DPVAQRAYKS YLGIVPSSPV GFENFTVMVN NYMEKPPFSF PNPLSQFGGG KLIRAEAAYL
YDAVHVYAKA LMKVMDSGGD PRNGTAIVEA MKNTHYKSAM GYIVFMDENG DAEGNYTLIA
RKVLRHNKEQ FGLFPVGIFA RTASRLPLLS GTISNDYHLV KGVLIGSTES LRLQPPFVDF
EEKNASVSFL LTHTIEITGG VAGGVVLIML IICLVLYRNW KYEQELDSLL WKIDYRDMEI
NGEPNSNVVG NKLPRSNQPF IRTSQVSLSS NPDADFRYST IFTQIGIYKG RVFAIKKVHK
KSIDITREMK KELKLMRDLR HDNLIAFIGA CTDPPNICIV TEYCTRGSLK DILENEDVKL
DNMFIASLVG DILRGMIYLH ESPIRFHGAL NSANCLVDSR WVVKLSDFGL REFKKGSDDF
SLKDPARIRE KCYKLLYRAP ELLRLQDSFL AKDQPMGTQK GDIYSFGIIL FELHNRHGPF
GDLPFSPGEI LNKVIHCSNP ASPFRPPLDK LENSCDFVKD CLKECWMEGP EERPDFKSIR
TKLRPLRKGM KPNIFDNMMA MMEKYANNLE VLVDERTDQL QEEKKKTEAL LYEMLPKPVA
DQLKKGNKVE AEGFDCVTIY FSDIVGFTAM SAESTPLQVV NFLNDLYTCF DSIIENYDVY
KVETIGDAYM VVSGLPIKND YQHAAEIATM SLHLLSEVKN FTIRHRPGQR LMLRIGIHSG
PVCAGVVGLK MPRYCLFGDT VNTASRMEST GQPLKIHCSR ACRDLLSRLG GYQLIERGLV
TMKGKGDQQT YWLLGEDFHF RKLRKELREK RRAEWRGRTV RTSNPDGNGH YIVTRSSLKN
KNSIVRSPIP RCSSFESPKR LRFANGDHLE KRSENKYLEA ITDNSPSRKD FQCLDSDSLV
TPYTIDCCAD IWKAASTSCP CIENLATSAA LVAQTQLAIL SDDQKLARPI CYSVPTLCCH
LSVPQGIPVH TISAPTSPRK QEVDLLARYS RDAEEIPVWT ESAPLLKITT PLDSETTCV
//
