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Database: UniProt
Entry: N6W541_9ALTE
LinkDB: N6W541_9ALTE
Original site: N6W541_9ALTE 
ID   N6W541_9ALTE            Unreviewed;       490 AA.
AC   N6W541;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=J057_08186 {ECO:0000313|EMBL:ENO15314.1};
OS   Marinobacter nanhaiticus D15-8W.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Marinobacter.
OX   NCBI_TaxID=626887 {ECO:0000313|EMBL:ENO15314.1, ECO:0000313|Proteomes:UP000013165};
RN   [1] {ECO:0000313|EMBL:ENO15314.1, ECO:0000313|Proteomes:UP000013165}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D15-8W {ECO:0000313|EMBL:ENO15314.1,
RC   ECO:0000313|Proteomes:UP000013165};
RX   PubMed=23723401;
RA   Cui Z., Gao W., Li Q., Xu G., Zheng L.;
RT   "Genome Sequence of the Polycyclic Aromatic Hydrocarbon-Degrading
RT   Bacterium Strain Marinobacter nanhaiticus D15-8WT.";
RL   Genome Announc. 1:e00301-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ENO15314.1}.
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DR   EMBL; APLQ01000011; ENO15314.1; -; Genomic_DNA.
DR   RefSeq; WP_004579610.1; NZ_KB822693.1.
DR   EnsemblBacteria; ENO15314; ENO15314; J057_08186.
DR   PATRIC; fig|626887.3.peg.1634; -.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000013165; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000013165};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013165}.
FT   DOMAIN      187    317       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      398    467       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     195    202       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   490 AA;  55863 MW;  6F32F0BC6FB9D9A8 CRC64;
     MPQTIWHQCL EVLRDEFPAQ QFNTWLRPLQ SDHRDDQLML FAPNRFVMDW VNEKYLRRIE
     EVLKDLQGGQ APRINMRVGS APEESAAAPV RRSSDTPRRQ TRQEDSAETV SEEEKGVAAT
     LVDRSSPTTA PAARPAASAR RSVQVEGDIK HQSFLNESFT FETFVEGKSN QLARAASMQV
     AENPGGAYNP LFLYGGVGLG KTHLMHAVGN EIVRRNPRAK VAYLRSERFV ADMVKALQLN
     AINEFKRYYR SVDALLIDDI QFFARKERSQ EEFFHTFNAL LEGGQQVIVT CDRFPKEISD
     MEERLKSRFG WGLTVMVEPP ELETRVAILM KKAEQANVRL SSEAAFFIAQ KIRSNVRELE
     GALRLVIANA HFTGQEITPP FIRESLKDLL ALHEKQVSID NIQRTVAEYY KIKVADLLSK
     RRTRTVTRPR QMAMSLAKEL TNHSLPEIGD AFGGRDHTTV LHACKKIVEL QESDTNIRED
     YQNFMRLLTT
//
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