ID   N6WE63_9ACTO            Unreviewed;       275 AA.
AC   N6WE63;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Glycerol uptake facilitator protein {ECO:0000313|EMBL:ENO18539.1};
GN   ORFNames=HMPREF9004_0588 {ECO:0000313|EMBL:ENO18539.1};
OS   Schaalia cardiffensis F0333.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Schaalia.
OX   NCBI_TaxID=888050 {ECO:0000313|EMBL:ENO18539.1, ECO:0000313|Proteomes:UP000013015};
RN   [1] {ECO:0000313|EMBL:ENO18539.1, ECO:0000313|Proteomes:UP000013015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0333 {ECO:0000313|EMBL:ENO18539.1,
RC   ECO:0000313|Proteomes:UP000013015};
RA   Aqrawi P., Ayvaz T., Bess C., Blankenburg K., Coyle M., Deng J., Forbes L.,
RA   Fowler G., Francisco L., Fu Q., Gibbs R., Gross S., Gubbala S., Hale W.,
RA   Hemphill L., Highlander S., Hirani K., Jackson L., Jakkamsetti A.,
RA   Javaid M., Jayaseelan J.C., Jiang H., Joshi V., Korchina V., Kovar C.,
RA   Lara F., Lee S., Liu Y., Mata R., Mathew T., Munidasa M., Muzny D.,
RA   Nazareth L., Ngo R., Nguyen L., Nguyen N., Okwuonu G., Ongeri F.,
RA   Palculict T., Patil S., Petrosino J., Pham C., Pham P., Pu L.-L., Qin X.,
RA   Qu J., Reid J., Ross M., Ruth R., Saada N., San Lucas F., Santibanez J.,
RA   Shang Y., Simmons D., Song X.-Z., Tang L.-Y., Thornton R., Warren J.,
RA   Weissenberger G., Wilczek-Boney K., Worley K., Youmans B., Zhang J.,
RA   Zhang L., Zhao Z., Zhou C., Zhu D., Zhu Y.;
RT   "Reference genome for the Human Microbiome Project.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ENO18539.1}.
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DR   EMBL; AQHZ01000010; ENO18539.1; -; Genomic_DNA.
DR   AlphaFoldDB; N6WE63; -.
DR   STRING; 888050.HMPREF9004_0588; -.
DR   PATRIC; fig|888050.3.peg.564; -.
DR   eggNOG; COG0580; Bacteria.
DR   HOGENOM; CLU_020019_9_2_11; -.
DR   Proteomes; UP000013015; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   GO; GO:0015791; P:polyol transmembrane transport; IEA:UniProt.
DR   Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR43829; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR   PANTHER; PTHR43829:SF9; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; Aquaporin-like; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013015};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000477};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT   TRANSMEM        63..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        123..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        171..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        252..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   275 AA;  28857 MW;  BEB95CDD9F16EC6C CRC64;
     MKRWRKIGKM LATLLPMAPQ EVTMTQIFMS EFMGTAVLLL LGGGVVATNL LPKSKGRNGG
     WLLINWGWGL AVLAGVYVAY GTGGHLNPAV TIAKVVGHMF NPEVTLNGPA LAEGGIPVTV
     ANVVVYIVAE FLGAFVGAIL CWLTFKQHFD EDLDPALKLG VFSTAPEIRS YGWNTLTEAI
     GTAVLILWIW VSGYTQTAIG PLAVALIIVV IGNSLGGPTG YAINPARDLG PRVAHAILPI
     KGKGGSDWGY SWVPVVGPTI GAIVGTVIAF VTGLA
//