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Database: UniProt
Entry: N6X3Z5_9ACTO
LinkDB: N6X3Z5_9ACTO
Original site: N6X3Z5_9ACTO 
ID   N6X3Z5_9ACTO            Unreviewed;       333 AA.
AC   N6X3Z5;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   31-JUL-2019, entry version 33.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165,
GN   ECO:0000313|EMBL:ENO18152.1};
GN   ORFNames=HMPREF9004_1096 {ECO:0000313|EMBL:ENO18152.1};
OS   Schaalia cardiffensis F0333.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Schaalia.
OX   NCBI_TaxID=888050 {ECO:0000313|EMBL:ENO18152.1, ECO:0000313|Proteomes:UP000013015};
RN   [1] {ECO:0000313|EMBL:ENO18152.1, ECO:0000313|Proteomes:UP000013015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0333 {ECO:0000313|EMBL:ENO18152.1,
RC   ECO:0000313|Proteomes:UP000013015};
RA   Aqrawi P., Ayvaz T., Bess C., Blankenburg K., Coyle M., Deng J.,
RA   Forbes L., Fowler G., Francisco L., Fu Q., Gibbs R., Gross S.,
RA   Gubbala S., Hale W., Hemphill L., Highlander S., Hirani K.,
RA   Jackson L., Jakkamsetti A., Javaid M., Jayaseelan J.C., Jiang H.,
RA   Joshi V., Korchina V., Kovar C., Lara F., Lee S., Liu Y., Mata R.,
RA   Mathew T., Munidasa M., Muzny D., Nazareth L., Ngo R., Nguyen L.,
RA   Nguyen N., Okwuonu G., Ongeri F., Palculict T., Patil S.,
RA   Petrosino J., Pham C., Pham P., Pu L.-L., Qin X., Qu J., Reid J.,
RA   Ross M., Ruth R., Saada N., San Lucas F., Santibanez J., Shang Y.,
RA   Simmons D., Song X.-Z., Tang L.-Y., Thornton R., Warren J.,
RA   Weissenberger G., Wilczek-Boney K., Worley K., Youmans B., Zhang J.,
RA   Zhang L., Zhao Z., Zhou C., Zhu D., Zhu Y.;
RT   "Reference genome for the Human Microbiome Project.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ENO18152.1}.
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DR   EMBL; AQHZ01000017; ENO18152.1; -; Genomic_DNA.
DR   STRING; 888050.HMPREF9004_1096; -.
DR   EnsemblBacteria; ENO18152; ENO18152; HMPREF9004_1096.
DR   PATRIC; fig|888050.3.peg.1041; -.
DR   BioCyc; GCF_000364865-HMP:HMPREF9004_RS09480-MONOMER; -.
DR   Proteomes; UP000013015; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070209};
KW   Complete proteome {ECO:0000313|Proteomes:UP000013015};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070206, ECO:0000313|EMBL:ENO18152.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070211};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070205};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013015};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070204, ECO:0000313|EMBL:ENO18152.1}.
FT   DOMAIN       19    205       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
FT   NP_BIND      21     28       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
FT   REGION      258    310       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    285    310       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   333 AA;  35587 MW;  63C27CB9D5AD94A4 CRC64;
     MERGTANEAA MAEGVFITFE GGDGSGKSTQ IQRVRDWFES QGRQVSVTRE PGGTELGKEI
     RRLVQNGPED VDPRSEALLY AADRAYHVAT RIRPALARGE VVLADRYIDS SVAYQGAARS
     LGVDEIRSLS VWATQGLNPE LTFLLDLPPE VGARRRTNAP DRLERESMEF HERVRHEYLR
     LADAEPDRII VIDAVGTPDE VFSEIRGVLE ERYPHSAPSA LTGETPCMGE APCMSDETPC
     PTEVDGAAAP DTAAAYGPAA KLASGSDAEP ESSAAPKPGP VAKLESTPTA TSDPTPVAKP
     ASSSSTDSAA PSLLSLLGSQ ETLWACEEED VLL
//
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