ID N6X3Z5_9ACTO Unreviewed; 333 AA.
AC N6X3Z5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 31-JUL-2019, entry version 33.
DE RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165,
GN ECO:0000313|EMBL:ENO18152.1};
GN ORFNames=HMPREF9004_1096 {ECO:0000313|EMBL:ENO18152.1};
OS Schaalia cardiffensis F0333.
OC Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Schaalia.
OX NCBI_TaxID=888050 {ECO:0000313|EMBL:ENO18152.1, ECO:0000313|Proteomes:UP000013015};
RN [1] {ECO:0000313|EMBL:ENO18152.1, ECO:0000313|Proteomes:UP000013015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0333 {ECO:0000313|EMBL:ENO18152.1,
RC ECO:0000313|Proteomes:UP000013015};
RA Aqrawi P., Ayvaz T., Bess C., Blankenburg K., Coyle M., Deng J.,
RA Forbes L., Fowler G., Francisco L., Fu Q., Gibbs R., Gross S.,
RA Gubbala S., Hale W., Hemphill L., Highlander S., Hirani K.,
RA Jackson L., Jakkamsetti A., Javaid M., Jayaseelan J.C., Jiang H.,
RA Joshi V., Korchina V., Kovar C., Lara F., Lee S., Liu Y., Mata R.,
RA Mathew T., Munidasa M., Muzny D., Nazareth L., Ngo R., Nguyen L.,
RA Nguyen N., Okwuonu G., Ongeri F., Palculict T., Patil S.,
RA Petrosino J., Pham C., Pham P., Pu L.-L., Qin X., Qu J., Reid J.,
RA Ross M., Ruth R., Saada N., San Lucas F., Santibanez J., Shang Y.,
RA Simmons D., Song X.-Z., Tang L.-Y., Thornton R., Warren J.,
RA Weissenberger G., Wilczek-Boney K., Worley K., Youmans B., Zhang J.,
RA Zhang L., Zhao Z., Zhou C., Zhu D., Zhu Y.;
RT "Reference genome for the Human Microbiome Project.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC Rule:MF_00165}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:ENO18152.1}.
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DR EMBL; AQHZ01000017; ENO18152.1; -; Genomic_DNA.
DR STRING; 888050.HMPREF9004_1096; -.
DR EnsemblBacteria; ENO18152; ENO18152; HMPREF9004_1096.
DR PATRIC; fig|888050.3.peg.1041; -.
DR BioCyc; GCF_000364865-HMP:HMPREF9004_RS09480-MONOMER; -.
DR Proteomes; UP000013015; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018094; Thymidylate_kinase.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW ECO:0000256|SAAS:SAAS01070209};
KW Complete proteome {ECO:0000313|Proteomes:UP000013015};
KW Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW ECO:0000256|SAAS:SAAS01070206, ECO:0000313|EMBL:ENO18152.1};
KW Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW ECO:0000256|SAAS:SAAS01070211};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW ECO:0000256|SAAS:SAAS01070205};
KW Reference proteome {ECO:0000313|Proteomes:UP000013015};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW ECO:0000256|SAAS:SAAS01070204, ECO:0000313|EMBL:ENO18152.1}.
FT DOMAIN 19 205 Thymidylate_kin. {ECO:0000259|Pfam:
FT PF02223}.
FT NP_BIND 21 28 ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
FT REGION 258 310 Disordered. {ECO:0000256|SAM:MobiDB-
FT lite}.
FT COMPBIAS 285 310 Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ SEQUENCE 333 AA; 35587 MW; 63C27CB9D5AD94A4 CRC64;
MERGTANEAA MAEGVFITFE GGDGSGKSTQ IQRVRDWFES QGRQVSVTRE PGGTELGKEI
RRLVQNGPED VDPRSEALLY AADRAYHVAT RIRPALARGE VVLADRYIDS SVAYQGAARS
LGVDEIRSLS VWATQGLNPE LTFLLDLPPE VGARRRTNAP DRLERESMEF HERVRHEYLR
LADAEPDRII VIDAVGTPDE VFSEIRGVLE ERYPHSAPSA LTGETPCMGE APCMSDETPC
PTEVDGAAAP DTAAAYGPAA KLASGSDAEP ESSAAPKPGP VAKLESTPTA TSDPTPVAKP
ASSSSTDSAA PSLLSLLGSQ ETLWACEEED VLL
//
