ID N6XU65_9RHOO Unreviewed; 1117 AA.
AC N6XU65;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Mechanosensitive channel MscK {ECO:0008006|Google:ProtNLM};
GN ORFNames=B447_02521 {ECO:0000313|EMBL:ENO82855.1};
OS Thauera sp. 27.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=305700 {ECO:0000313|EMBL:ENO82855.1, ECO:0000313|Proteomes:UP000013140};
RN [1] {ECO:0000313|EMBL:ENO82855.1, ECO:0000313|Proteomes:UP000013140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=27 {ECO:0000313|EMBL:ENO82855.1,
RC ECO:0000313|Proteomes:UP000013140};
RA Liu B., Shapleigh J.P., Frostegard A.H.;
RT "Draft Genome Sequences of 6 Strains from Genus Thauera.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENO82855.1}.
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DR EMBL; AMXB01000003; ENO82855.1; -; Genomic_DNA.
DR RefSeq; WP_002936118.1; NZ_AMXB01000003.1.
DR AlphaFoldDB; N6XU65; -.
DR eggNOG; COG3264; Bacteria.
DR Proteomes; UP000013140; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF8; MECHANOSENSITIVE CHANNEL MSCK; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 493..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..939
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..273
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 501..823
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 884..925
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 927..992
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 1000..1083
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
SQ SEQUENCE 1117 AA; 123329 MW; 09FF26A575A9DEAE CRC64;
MPSFPHLVRL LVLLLLPLLV LRAAAEPPLP PAAKELQARA AALAERQLPE SERQAAQQAL
DQALSRLAAA EDYRQQLSTL NERLAAAPRQ IATARTQLDA LQAKAEPDQA AALGPELSAG
VLEQRLAERN AELSQWQRSL DEADALLLSA RTGPERAQTE ISTNQTRMTA IEAALSANRE
QGPGREARSL TTERRDALAA EWHALDAQNR LRQLELSGSS VLQDLGQARR ELAAEHLRRL
GAETHALQSA INARRSADAV ETVEALRREQ AQTPDTGGLI AREIAANQRV SEYLLRATEH
LNTLTQRNLA TRQQLDSLNR AGTIIDEQIN VLQGSLLLSR ILLEQKRALP QPRVDKQLAE
QIADIRLYQF EVSKQREQLG TPAAHAERLL AELPPEQADE TMRSQLLGLL TARAELLERL
NRELSAVLNE SITLQLSERQ LQATADRLRS TLDEQMFWIP SNRPLDAAWV MAVPAALQAQ
LAAIPWQSAS TELWAGLKAR PLLFLPVLLL TLWLLSRRRW LRARLDGLHA DIGYVRRDSQ
LHTPLAILFN ILLALPVSLL LALAGLALQM DARGQNASLG AALLQMAQAW LVFYTAYRVL
APAGVAERHF RWPLERVREL HRHMRHLGLV VLAVVAVVAM AERQPEALAN DVLGILILLA
GYATMAWLMA RLLIHRSQQD RPSPLRVAIG VALGLMPLAL IAALLMGYYY TALKLTGRLI
DTLFVLILWR LVEATVIRAL GVAARRLDHQ QAVARREAAE REGLPGADTD DGIEPPRFDI
DRISQQSLRL LHLGLLAGLL LSLYWVWADL ITVFAYLDNI TLYEYASGSG DTASVTPISL
RDLIAALVIG SIAFLLARNL PGLLEVLVLS RLQLAQGSAY ATTTLLSYVI MAVGIVATLG
SLGVSWDKLQ WLVAALSVGL GFGLQEIFAN FVSGLIILFE RPVRIGDTVT IGNVSGTVTR
IQIRATTITD FDRKEMIVPN KAFITGQLTN WSLTDTVTRI TVKVGVAYGS DLELTRKLLL
RIAEDNTRVL KEPKPLVFFL SFGPSTLDHE LRVHVRELGD RNAAIDEINR EIDRLFKEHG
IEIAFNQMDV HIRSIDGKEA RLQTIEAPRA GGGGELK
//
