ID N6Y5X3_9RHOO Unreviewed; 730 AA.
AC N6Y5X3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Ornithine--oxo-acid aminotransferase {ECO:0000256|ARBA:ARBA00030587};
DE EC=2.6.1.13 {ECO:0000256|ARBA:ARBA00012924};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168};
GN ORFNames=C664_11380 {ECO:0000313|EMBL:ENO77468.1};
OS Thauera sp. 63.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=497321 {ECO:0000313|EMBL:ENO77468.1, ECO:0000313|Proteomes:UP000013007};
RN [1] {ECO:0000313|EMBL:ENO77468.1, ECO:0000313|Proteomes:UP000013007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=63 {ECO:0000313|EMBL:ENO77468.1,
RC ECO:0000313|Proteomes:UP000013007};
RA Liu B., Shapleigh J.P., Frostegard A.H.;
RT "Draft Genome Sequences of 6 Strains from Genus Thauera.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000227};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate
CC 5-semialdehyde from L-ornithine: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004998}.
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENO77468.1}.
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DR EMBL; AMXC01000011; ENO77468.1; -; Genomic_DNA.
DR RefSeq; WP_004259849.1; NZ_AMXC01000011.1.
DR AlphaFoldDB; N6Y5X3; -.
DR eggNOG; COG0010; Bacteria.
DR eggNOG; COG4992; Bacteria.
DR OrthoDB; 3398487at2; -.
DR UniPathway; UPA00098; UER00358.
DR UniPathway; UPA00158; UER00270.
DR Proteomes; UP000013007; Unassembled WGS sequence.
DR GO; GO:0004053; F:arginase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004587; F:ornithine aminotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd09989; Arginase; 1.
DR CDD; cd00610; OAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR049704; Aminotrans_3_PPA_site.
DR InterPro; IPR014033; Arginase.
DR InterPro; IPR010164; Orn_aminotrans.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR NCBIfam; TIGR01885; Orn_aminotrans; 1.
DR PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1.
DR PANTHER; PTHR11986:SF18; ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00202; Aminotran_3; 1.
DR Pfam; PF00491; Arginase; 1.
DR PRINTS; PR00116; ARGINASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
DR PROSITE; PS01053; ARGINASE_1; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022576}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..730
FT /note="Ornithine--oxo-acid aminotransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004128623"
SQ SEQUENCE 730 AA; 76919 MW; 0B30A54367311B11 CRC64;
MTTNPGALRA PHALVSIIGA ASALGAPHAG TAAAPAALQD SPLRQRLAGL GPAAEWAAIL
SPDVPPAHVT SARARAGKED HIAGSDMAAR IAANADFARC LADRIATLPA DRFPLVLGGD
HAVAAGTWRG IGRRRARAPG LIWIDAHLDS HTDATTHSGN IHGMPLAALL GTGHAALTGI
PGPALDPART CIIGARAWEP EELALLTRLG VRVFTMSEVR ARGLSAVFAD ALRLARADPD
AGFGLSLDLD ALDPQAFPAV TCPEPGGIEP RTLADALLGL RACADLVGLE IVEYRPDLDA
DHRGADWIAE FVLAALGPST DWLRAAERRF GATNYAPLPA VFQRGEGVWL WDTDGRRYLD
MMSAYSAMSF GHGHPRLVRA LVDQAQRLAL TSRAFSSDRL PVFLERLCAT FGYECALPVN
TGLEAVETAL KAARKWGYKV KGIAPERARI LACDGNFHGR SIAIVGLSAN AQYRNGFGPF
PPGFERVPFG NVDALEAAIT PDTAAFLVEP IQGEGGIVVP PPGYLSRCAE ICRRHDVLLI
ADEVQTGLGR TGRLLACEHD GVRPDGLILG KALGGGLLPV SAFLADRRVM DVFGPGDHGS
TFGGNPLAAA VGTEVLALLA ETRPWERAAR LGTQLMETLR AAALPCVREV RGRGLLVGLA
LDPALADASE VVTQLLARGI ATRDTHGNVI RLAPPLTIDE ATLDEAARRI LDTLRMLTPA
GVDADVVRMQ
//
