ID N9W8E8_9SPHN Unreviewed; 416 AA.
AC N9W8E8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:ENY80003.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:ENY80003.1};
GN ORFNames=EBMC1_16079 {ECO:0000313|EMBL:ENY80003.1};
OS Sphingopyxis sp. MC1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingopyxis.
OX NCBI_TaxID=1174684 {ECO:0000313|EMBL:ENY80003.1, ECO:0000313|Proteomes:UP000013072};
RN [1] {ECO:0000313|EMBL:ENY80003.1, ECO:0000313|Proteomes:UP000013072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC1 {ECO:0000313|EMBL:ENY80003.1,
RC ECO:0000313|Proteomes:UP000013072};
RA Lolas I.B., Kjeldal H., Almeida B., Le-Quy V., Gough H.L., Nielsen J.L.;
RT "Differential expression analysis of membrane associated proteins from
RT triclosan-degrading sphingopyxis.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENY80003.1}.
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DR EMBL; AOUN01000022; ENY80003.1; -; Genomic_DNA.
DR RefSeq; WP_003051296.1; NZ_AOUN01000022.1.
DR AlphaFoldDB; N9W8E8; -.
DR PATRIC; fig|1174684.3.peg.3248; -.
DR eggNOG; COG0183; Bacteria.
DR Proteomes; UP000013072; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:ENY80003.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000013072};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ENY80003.1}.
FT DOMAIN 5..235
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 293..415
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 92
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 372
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 402
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 416 AA; 43804 MW; 67A9BDC124009AC0 CRC64;
MAEAYIIDAV RTPRGIGKPG KGALSHLHPQ HLAATVLAAI RDRNHLDTAT VDDIVWSTSS
QNGKQGGDLG RMAALSAGYD TKASGTTLDR FCGGGISSVN FAAASVMSGM EDCVIAGGTE
MMSYTTAFAA EQANAGLPPR LMGSGHEALD EIHPQSHQGI CGDAIATIEG ISREALDALA
LVSQQRADRA IKEGRFNKSV VPVLNPDGSV ALDHEEFPRP ETTAEGLASL KPSFAALADF
DMGGGFTFRK QINRRYPDLE IRHFHHAGNS SGVVDGAAAI LLTSKDYADK HGLKPRARVV
AYANIGDDPT LMLNAPVPAA KKVLEKAGLT KDDIDVWEIN EAFSVVAEKF IRDLDLDREK
VNINGGAMAL GHPIGATGSI LIGTALDELE RSGGRYGLVT MCAAGGMAPA IIIERI
//
