ID N9WG82_9CLOT Unreviewed; 1000 AA.
AC N9WG82;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=CzcA family heavy metal efflux pump {ECO:0000313|EMBL:ENZ01885.1};
GN ORFNames=HMPREF1092_01119 {ECO:0000313|EMBL:ENZ01885.1};
OS Clostridium thermobutyricum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=29372 {ECO:0000313|EMBL:ENZ01885.1, ECO:0000313|Proteomes:UP000013097};
RN [1] {ECO:0000313|EMBL:ENZ01885.1, ECO:0000313|Proteomes:UP000013097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=209318 {ECO:0000313|EMBL:ENZ01885.1,
RC ECO:0000313|Proteomes:UP000013097};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Courvalin P., Lambert T.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B.,
RA Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Larimer J., McCowan C., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Clostridium colicanis 209318.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ENZ01885.1}.
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DR EMBL; AGYT01000008; ENZ01885.1; -; Genomic_DNA.
DR RefSeq; WP_002597621.1; NZ_KB850956.1.
DR AlphaFoldDB; N9WG82; -.
DR PATRIC; fig|999411.4.peg.1094; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_9; -.
DR Proteomes; UP000013097; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF0; SWARMING MOTILITY PROTEIN SWRC; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000013097};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..989
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1000 AA; 109319 MW; 6DEC6712F1A930AD CRC64;
MKISEFSIKR PITIFMGIVA LLIFGIVSYS RLNLDMLPTM DVPIILVNTQ YIGAGPTDVE
GEVTKPLENV ISTVSNVENV KSISREGMST IIIQFADGTD MNFASLELRE KVDMIKELLP
KEIIQPMIVQ MDPSMMPIMN LGVSFKGDRN DKIGNFADEV LKNSIESVEG VASVDISGNV
KKGIKIEVDN DKLSSNGINI QSLIAAIKSE NVNIPIGSIV EGDYGVLVRT SNSIKNLDDI
KNIRIKTNSG EVVKLSDIAN IGYEDKKEES FSKIDGNDAL ILTIQKESTA NTVDVSRKIN
KKLEELKEKN SDLEVIKIID QGEIIEFMVS AVKKNAVIGG ILAIIVLLLF LKDIRTTIIM
GISIPISIVW TFVMVYFSGL TLNMISLGGI ALGIGMLVDN SIVVIESIYR YKKLGYNNSE
AALYGTKEVS KAIIASTITS ICVFLPIVFV QGIAADIFKE MALTVTFSLI SSLIVSFTLV
PVLASKLLKN DSLNKENKTV EKLKKLYEKA LIYSLDKRKN IIGLVVLFII LGGIAFSGVG
IEFFPTSDQG IVNVKLETPN GTLNNILKEE SLKLADEVKE VDGVANVSLK GKDNTASMSI
LLDKNRKKSD KEIARDIRKV LSDVPGVKVE VSTGGTQMSQ GSPISISVKG ADFNVLEEVS
NEVLKRMETI SGIENIKSTN SDKSEEIKIS IDKEKSAKYG LNALTISQSI SGYFKNTRVM
NLRIDDSNYE VYISPISNKN PDLESLKEVT VTSITGSKIP LLQICKIERG EGFSEIYRTD
GLREVTISAG LDGKPLNEAV KEIKNSLNDY NIPQGYEIVY GGEIEQMKDA FSQMALALIL
AVLLVYMVMA AQFESLINPF IIMFTVPLAF IGAIIVLFYT GVTISIPAMI GFVMLTGIIV
NNGIVLIDFI NKEKEKGIDT RQAIINSGKT RLQPILMTAL TTIIGLLPMA LGIGEGNEIQ
LPLAMTVIGG LTIGTLLTLI VIPVVYSIFE QIAKKFKRKK
//
