ID NADHK_ORYSJ Reviewed; 325 AA.
AC Q6EQG2; Q0J2G4;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Probable NADH kinase;
DE EC=2.7.1.86;
GN OrderedLocusNames=Os09g0345700, LOC_Os09g17680; ORFNames=OSJNBb0085I16.26;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Key source of the cellular reductant NADPH which is an
CC important antioxidant factor. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + NADH = ADP + H(+) + NADPH; Xref=Rhea:RHEA:12260,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:456216; EC=2.7.1.86;
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NAD kinase family. {ECO:0000305}.
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DR EMBL; AP005700; BAD29108.1; -; Genomic_DNA.
DR EMBL; AP008215; BAF24851.1; -; Genomic_DNA.
DR EMBL; AP014965; BAT07607.1; -; Genomic_DNA.
DR EMBL; AK073719; BAG93606.1; -; mRNA.
DR RefSeq; XP_015651403.1; XM_015795917.1.
DR AlphaFoldDB; Q6EQG2; -.
DR SMR; Q6EQG2; -.
DR STRING; 39947.Q6EQG2; -.
DR PaxDb; 39947-Q6EQG2; -.
DR EnsemblPlants; Os09t0345700-01; Os09t0345700-01; Os09g0345700.
DR GeneID; 4346801; -.
DR Gramene; Os09t0345700-01; Os09t0345700-01; Os09g0345700.
DR KEGG; osa:4346801; -.
DR eggNOG; KOG4180; Eukaryota.
DR HOGENOM; CLU_067437_0_0_1; -.
DR InParanoid; Q6EQG2; -.
DR OMA; KSVEWKA; -.
DR OrthoDB; 35905at2759; -.
DR Proteomes; UP000000763; Chromosome 9.
DR Proteomes; UP000059680; Chromosome 9.
DR Genevisible; Q6EQG2; OS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003951; F:NAD+ kinase activity; IBA:GO_Central.
DR GO; GO:0042736; F:NADH kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019674; P:NAD metabolic process; IEA:InterPro.
DR GO; GO:0006741; P:NADP biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR002504; NADK.
DR PANTHER; PTHR20275; NAD KINASE; 1.
DR PANTHER; PTHR20275:SF28; NADH KINASE; 1.
DR Pfam; PF01513; NAD_kinase; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Kinase; NAD; NADP; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..325
FT /note="Probable NADH kinase"
FT /id="PRO_0000233701"
SQ SEQUENCE 325 AA; 35517 MW; D4A17F7204735D4B CRC64;
MALRRVLLFV KPFDVYPPRP LAAAASSPPP PPPPLRVSNP KVLNYLDDRC RVHKETINLC
KSVLQRKSID WISVQRNDMS NPIHDVDLVI SVGGDGTLLR ASHFLNSSIP VLGVNSDPTC
PDEVDELTDE FDARRSTGHL CAATAANFEQ ILDATLDGSR QPSELSRISV KLNGLQLPTY
ALNDILVSHP CPASVSRFSF RKRSNTGESS HLINCRSSGL RVATPAGSTA AMLSAGGFVM
PISSHELQYM IREPISPRDA DKPLLHGLVK QGQHILVVWY NEEGAVYFDG SHVMHSIQHG
DTLEISSDAP ILKVILPENL LKQGS
//
