ID NAL4C_MOUSE Reviewed; 982 AA.
AC Q3TKR3; Q66X27;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 136.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 4C;
DE AltName: Full=NALP-alpha;
GN Name=Nlrp4c; Synonyms=Nalp4c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15317747; DOI=10.1093/hmg/ddh241;
RA Hamatani T., Falco G., Carter M.G., Akutsu H., Stagg C.A., Sharov A.A.,
RA Dudekula D.B., VanBuren V., Ko M.S.H.;
RT "Age-associated alteration of gene expression patterns in mouse oocytes.";
RL Hum. Mol. Genet. 13:2263-2278(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in inflammation and recognition of cytosolic
CC pathogen-associated molecular patterns (PAMPs) not intercepted by
CC membrane-bound receptors. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NLRP family. {ECO:0000305}.
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DR EMBL; AY596194; AAU06315.1; -; mRNA.
DR EMBL; AK166817; BAE39043.1; -; mRNA.
DR EMBL; AK166869; BAE39081.1; -; mRNA.
DR CCDS; CCDS51988.1; -.
DR RefSeq; NP_113566.2; NM_031389.2.
DR AlphaFoldDB; Q3TKR3; -.
DR SMR; Q3TKR3; -.
DR BioGRID; 219949; 1.
DR STRING; 10090.ENSMUSP00000046503; -.
DR iPTMnet; Q3TKR3; -.
DR PhosphoSitePlus; Q3TKR3; -.
DR MaxQB; Q3TKR3; -.
DR PaxDb; 10090-ENSMUSP00000046503; -.
DR ProteomicsDB; 293618; -.
DR DNASU; 83564; -.
DR Ensembl; ENSMUST00000037728.13; ENSMUSP00000046503.6; ENSMUSG00000034690.14.
DR Ensembl; ENSMUST00000121583.2; ENSMUSP00000113824.2; ENSMUSG00000034690.14.
DR Ensembl; ENSMUST00000208360.2; ENSMUSP00000146613.2; ENSMUSG00000034690.14.
DR GeneID; 83564; -.
DR KEGG; mmu:83564; -.
DR UCSC; uc009fan.2; mouse.
DR AGR; MGI:1890518; -.
DR CTD; 83564; -.
DR MGI; MGI:1890518; Nlrp4c.
DR VEuPathDB; HostDB:ENSMUSG00000034690; -.
DR eggNOG; ENOG502SGVH; Eukaryota.
DR GeneTree; ENSGT00940000162284; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; Q3TKR3; -.
DR OMA; THPDCRV; -.
DR OrthoDB; 55870at2759; -.
DR PhylomeDB; Q3TKR3; -.
DR Reactome; R-MMU-3134975; Regulation of innate immune responses to cytosolic DNA.
DR Reactome; R-MMU-3270619; IRF3-mediated induction of type I IFN.
DR BioGRID-ORCS; 83564; 3 hits in 79 CRISPR screens.
DR PRO; PR:Q3TKR3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3TKR3; Protein.
DR Bgee; ENSMUSG00000034690; Expressed in primary oocyte and 30 other cell types or tissues.
DR Genevisible; Q3TKR3; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045824; P:negative regulation of innate immune response; ISO:MGI.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF6; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Inflammatory response; Leucine-rich repeat;
KW Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..982
FT /note="NACHT, LRR and PYD domains-containing protein 4C"
FT /id="PRO_0000286331"
FT DOMAIN 1..93
FT /note="Pyrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00061"
FT DOMAIN 148..471
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 594..617
FT /note="LRR 1"
FT REPEAT 689..716
FT /note="LRR 2"
FT REPEAT 746..773
FT /note="LRR 3"
FT REPEAT 802..825
FT /note="LRR 4"
FT REPEAT 827..844
FT /note="LRR 5"
FT REPEAT 859..882
FT /note="LRR 6"
FT REPEAT 916..940
FT /note="LRR 7"
FT BINDING 154..161
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT CONFLICT 892
FT /note="E -> Q (in Ref. 1; AAU06315)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 982 AA; 112674 MW; 612D76CC6F0D4398 CRC64;
MASFFSDFGL MWYLEELNKK EFMKFKEFLK QEILQLRLKQ ISWTEVKKAS REDLANLLLK
HYEEKKAWDM TFKIFQKMNR KDLMERAGRE IAGHSKLYQA HLKKKLTHDY ARKFNIKVQD
FSKQKFTQDD YDRFENFLIS KVTAKKPHMV FLQGAAGIGK SLMLTKLMLA WSEGMVFQNK
FSYIFYFCCQ DVKKMKRASL AELISKEWPK TSAPIEDILS QPEKLLFVID NLEVMECDMS
ERESELCDTC TEKQPVRILL SSLLRRKMLP KSSFLISATP ETFEKMEGRV ECTNVKIVTG
FNESNIKMYF RSLFQDKTKT QEIFSLVKEN QQLFTVCQVP VLCWMVATCL KKEIEKGRDL
VSVCRRTTSL YTTHIFNLFI PQSAQYPSKE SQAQLQSLCS LAAEGMWTDT FVFGEEALRR
NGIMDSDIPT LLDVRILEKS KKSEKSYIFL HPSIQEVCAA IFYLLKSHMD HPSQDVKSIE
ALIFTFLKKV KVQWIFFGSF IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNE
ELQEQVDGMK LFYCLFEMDD EAFLAQAMNC MEQINFVAKD YSDVIVAAHC LQHCSTLKKL
SLSTQNVLSE GQEHSYTEKL LMCWHHMCSV LISSKDIYIL QVKNTNLNET ASLVLYSHLM
YPSCTLKALV VNNVTFLCDN RLFFELIQNQ CLQHLDLNLT FLSHGDVKLL CDVLSQEECN
IEKLMVAACN LSPDDCKVFA SVLISSKMLK HLNLSSNNLD KGISSLSKAL CHPDCVLKNL
VLVNCSLSEQ CWDYLSEVLR RNKTLNHLDI SSNDLKDEGL KVLCGALSLP DSVLKSLSVR
YCLITTSGCQ DLAEVLRKNQ NLRNLQVSNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA
LTGACCEDLA SAFTHCKTLW GINLQENALD HSGLIVLFEA LKQQQCTLHV LGLRITDFDK
ETQELLMAEE EKNPHLSILS SV
//
