ID NANR_CITRI Reviewed; 260 AA.
AC D2TP58;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=HTH-type transcriptional repressor NanR {ECO:0000255|HAMAP-Rule:MF_01236};
GN Name=nanR {ECO:0000255|HAMAP-Rule:MF_01236}; OrderedLocusNames=ROD_45961;
OS Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter.
OX NCBI_TaxID=637910;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICC168;
RX PubMed=19897651; DOI=10.1128/jb.01144-09;
RA Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N.,
RA Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L.,
RA Parkhill J., Dougan G., Frankel G., Thomson N.R.;
RT "The Citrobacter rodentium genome sequence reveals convergent evolution
RT with human pathogenic Escherichia coli.";
RL J. Bacteriol. 192:525-538(2010).
CC -!- FUNCTION: Transcriptional repressor that controls expression of the
CC genes required for the catabolism of sialic acids. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
CC -!- SIMILARITY: Belongs to the NanR family. {ECO:0000255|HAMAP-
CC Rule:MF_01236}.
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DR EMBL; FN543502; CBG91291.1; -; Genomic_DNA.
DR RefSeq; WP_012908490.1; NC_013716.1.
DR AlphaFoldDB; D2TP58; -.
DR SMR; D2TP58; -.
DR STRING; 637910.ROD_45961; -.
DR KEGG; cro:ROD_45961; -.
DR eggNOG; COG2186; Bacteria.
DR HOGENOM; CLU_017584_9_1_6; -.
DR OrthoDB; 7005926at2; -.
DR Proteomes; UP000001889; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.20.120.530; GntR ligand-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01236; HTH_NanR; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR023730; Tscrpt_reg_NanR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43537:SF23; HTH-TYPE TRANSCRIPTIONAL REPRESSOR NANR; 1.
DR PANTHER; PTHR43537; TRANSCRIPTIONAL REGULATOR, GNTR FAMILY; 1.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00895; FCD; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF48008; GntR ligand-binding domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..260
FT /note="HTH-type transcriptional repressor NanR"
FT /id="PRO_0000415296"
FT DOMAIN 27..95
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
FT DNA_BIND 55..74
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01236"
SQ SEQUENCE 260 AA; 29212 MW; 48AF5E2237A243BA CRC64;
MKTFDSQAEN SPAVIGRSLR NRPLARKKLS EMVEEELEQM IRRKEFGEGE QLPSERELMA
FFNVGRPSVR EALAALKRKG LVQINNGERA RVSRPSADTI IGELSGMAKD FLAHPGGIAH
FEQLRLFFES SLVRYAAENA TDAQIDLLAK ALEINSQSLD DNALFIRSDV DFHRVLAEIP
GNPIFKAIHV ALLDWLIAAR PTVPDRELYE HNSVSYQQHI AIVDAIRQRD PDAADRALQT
HLNSVSATWH ALGQQSKRKK
//
