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Database: UniProt
Entry: NAT12_ARATH
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Original site: NAT12_ARATH 
ID   NAT12_ARATH             Reviewed;         709 AA.
AC   Q3E7D0; Q8LPL9; Q9ZUY2;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 3.
DT   24-JAN-2024, entry version 122.
DE   RecName: Full=Nucleobase-ascorbate transporter 12;
DE            Short=AtNAT12;
GN   Name=NAT12; OrderedLocusNames=At2g27810; ORFNames=F15K20.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GENE FAMILY, SUBCELLULAR LOCATION,
RP   AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Columbia;
RX   PubMed=16982705; DOI=10.1093/pcp/pcl011;
RA   Maurino V.G., Grube E., Zielinski J., Schild A., Fischer K., Flugge U.-I.;
RT   "Identification and expression analysis of twelve members of the
RT   nucleobase-ascorbate transporter (NAT) gene family in Arabidopsis
RT   thaliana.";
RL   Plant Cell Physiol. 47:1381-1393(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=cv. La-0;
RX   PubMed=14506206; DOI=10.1074/mcp.t300006-mcp200;
RA   Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
RT   "Large-scale analysis of in vivo phosphorylated membrane proteins by
RT   immobilized metal ion affinity chromatography and mass spectrometry.";
RL   Mol. Cell. Proteomics 2:1234-1243(2003).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15308754; DOI=10.1105/tpc.104.023150;
RA   Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
RT   "Phosphoproteomics of the Arabidopsis plasma membrane and a new
RT   phosphorylation site database.";
RL   Plant Cell 16:2394-2405(2004).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19376835; DOI=10.1104/pp.109.138677;
RA   Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA   Grossmann J., Gruissem W., Baginsky S.;
RT   "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT   chloroplast kinase substrates and phosphorylation networks.";
RL   Plant Physiol. 150:889-903(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16982705};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:16982705}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3E7D0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3E7D0-2; Sequence=VSP_022177;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16982705}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC73019.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY444865; AAR18374.1; -; mRNA.
DR   EMBL; AC005824; AAC73019.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC08047.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC08048.1; -; Genomic_DNA.
DR   EMBL; AY099545; AAM20397.1; -; mRNA.
DR   EMBL; BT002121; AAN72132.1; -; mRNA.
DR   PIR; C84677; C84677.
DR   RefSeq; NP_850108.1; NM_179777.2. [Q3E7D0-1]
DR   RefSeq; NP_973550.2; NM_201821.2. [Q3E7D0-2]
DR   AlphaFoldDB; Q3E7D0; -.
DR   SMR; Q3E7D0; -.
DR   STRING; 3702.Q3E7D0; -.
DR   TCDB; 2.A.40.6.6; the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.
DR   iPTMnet; Q3E7D0; -.
DR   PaxDb; 3702-AT2G27810-1; -.
DR   ProteomicsDB; 251247; -. [Q3E7D0-1]
DR   EnsemblPlants; AT2G27810.1; AT2G27810.1; AT2G27810. [Q3E7D0-1]
DR   EnsemblPlants; AT2G27810.2; AT2G27810.2; AT2G27810. [Q3E7D0-2]
DR   GeneID; 817328; -.
DR   Gramene; AT2G27810.1; AT2G27810.1; AT2G27810. [Q3E7D0-1]
DR   Gramene; AT2G27810.2; AT2G27810.2; AT2G27810. [Q3E7D0-2]
DR   KEGG; ath:AT2G27810; -.
DR   Araport; AT2G27810; -.
DR   TAIR; AT2G27810; NAT12.
DR   eggNOG; KOG1292; Eukaryota.
DR   InParanoid; Q3E7D0; -.
DR   OMA; NNVSAYC; -.
DR   PhylomeDB; Q3E7D0; -.
DR   PRO; PR:Q3E7D0; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q3E7D0; baseline and differential.
DR   Genevisible; Q3E7D0; AT.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0015207; F:adenine transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0015208; F:guanine transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0015294; F:solute:monoatomic cation symporter activity; IDA:TAIR.
DR   GO; GO:0015210; F:uracil transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0098702; P:adenine import across plasma membrane; IDA:TAIR.
DR   GO; GO:0098710; P:guanine import across plasma membrane; IDA:TAIR.
DR   GO; GO:0035344; P:hypoxanthine transport; IDA:TAIR.
DR   GO; GO:0098721; P:uracil import across plasma membrane; IDA:TAIR.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR11119:SF28; NUCLEOBASE-ASCORBATE TRANSPORTER 12; 1.
DR   PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..709
FT                   /note="Nucleobase-ascorbate transporter 12"
FT                   /id="PRO_0000270169"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        530..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        551..571
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        585..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        639..659
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..23
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:14506206"
FT   VAR_SEQ         590..709
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_022177"
SQ   SEQUENCE   709 AA;  76674 MW;  BD6CE057C49EF3FB CRC64;
     MSSSDPKPGP KPGPWPPTPE SAAMPPSSWA KKTGFRPKFS GETTATDSSS GQLSLPVRAK
     QQETQPDLEA GQTRLRPPPP VSAAVTNGET DKDKKEKPPP PPPGSVAVPV KDQPVKRRRD
     SDGVVGRSNG PDGANGSGDP VRRPGRIEET VEVLPQSMDD DLVARNLHMK YGLRDTPGLV
     PIGFYGLQHY LSMLGSLILV PLVIVPAMGG SHEEVANVVS TVLFVSGITT LLHTSFGSRL
     PLIQGPSFVF LAPALAIINS PEFQGLNGNN NFKHIMRELQ GAIIIGSAFQ AVLGYSGLMS
     LILRLVNPVV VAPTVAAVGL SFYSYGFPLV GKCLEIGVVQ ILLVIIFALY LRKISVLSHR
     IFLIYAVPLS LAITWAAAFL LTETGAYTYK GCDPNVPVSN VVSTHCRKYM TRMKYCRVDT
     SHALSSAPWF RFPYPLQWGV PLFNWKMAFV MCVVSVIASV DSVGSYHASS LLVASRPPTR
     GVVSRAIGLE GFTSVLAGLW GTGTGSTTLT ENVHTIAVTK MGSRRVVELG ACVLVIFSLV
     GKVGGFLASI PQVMVASLLC FMWAMFTALG LSNLRYSEAG SSRNIIIVGL SLFFSLSVPA
     YFQQYGISPN SNLSVPSYYQ PYIVSSHGPF KSQYKGMNYV MNTLLSMSMV IAFIMAVILD
     NTVPGSKQER GVYVWSDSET ATREPALAKD YELPFRVGRF FRWVKWVGI
//
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