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Database: UniProt
Entry: NDUAA_PANTR
LinkDB: NDUAA_PANTR
Original site: NDUAA_PANTR 
ID   NDUAA_PANTR             Reviewed;         355 AA.
AC   Q0MQB7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   28-MAR-2018, entry version 84.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial;
DE   AltName: Full=Complex I-42kD;
DE            Short=CI-42kD;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 42 kDa subunit;
DE   Flags: Precursor;
GN   Name=NDUFA10;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V.,
RA   Gaut B., Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane
CC       respiratory chain NADH dehydrogenase (Complex I), that is believed
CC       not to be involved in catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The
CC       immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone. {ECO:0000250|UniProtKB:O95299}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits. This a
CC       component of the hydrophobic protein fraction.
CC       {ECO:0000250|UniProtKB:O95299}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:O95299}.
CC   -!- PTM: Phosphorylation at Ser-250 by PINK1 is required for the
CC       binding and/or reduction of the complex I substrate ubiquinone.
CC       {ECO:0000250|UniProtKB:Q99LC3}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC       {ECO:0000305}.
DR   EMBL; DQ885717; ABH12226.1; -; mRNA.
DR   RefSeq; NP_001065273.1; NM_001071805.1.
DR   UniGene; Ptr.4922; -.
DR   ProteinModelPortal; Q0MQB7; -.
DR   STRING; 9598.ENSPTRP00000022417; -.
DR   PaxDb; Q0MQB7; -.
DR   GeneID; 470696; -.
DR   KEGG; ptr:470696; -.
DR   CTD; 4705; -.
DR   eggNOG; KOG3877; Eukaryota.
DR   eggNOG; ENOG41101CN; LUCA.
DR   HOGENOM; HOG000267026; -.
DR   HOVERGEN; HBG002308; -.
DR   InParanoid; Q0MQB7; -.
DR   KO; K03954; -.
DR   OMA; KPHLVIY; -.
DR   OrthoDB; EOG091G0WZ0; -.
DR   TreeFam; TF314616; -.
DR   Proteomes; UP000002277; Unplaced.
DR   Bgee; ENSPTRG00000013099; -.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   CDD; cd02030; NDUO42; 1.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR015828; NDUFA10.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Electron transport; FAD; Flavoprotein;
KW   Mitochondrion; Phosphoprotein; Reference proteome; Respiratory chain;
KW   Transit peptide; Transport.
FT   TRANSIT       1     35       Mitochondrion.
FT                                {ECO:0000250|UniProtKB:P34942}.
FT   CHAIN        36    355       NADH dehydrogenase [ubiquinone] 1 alpha
FT                                subcomplex subunit 10, mitochondrial.
FT                                /FTId=PRO_0000251813.
FT   MOD_RES     250    250       Phosphoserine; by PINK1.
FT                                {ECO:0000250|UniProtKB:Q99LC3}.
FT   MOD_RES     285    285       N6-succinyllysine.
FT                                {ECO:0000250|UniProtKB:Q99LC3}.
SQ   SEQUENCE   355 AA;  40679 MW;  B534F48D4B5A50FB CRC64;
     MALRLLKLAA TSASARVVAA GAQRVRGVHS SVQCKLRYGM WHFLLGDKAS KRLTERSRVI
     TVDGNICTGK GKLAKEIAEK LGFKHFPEAG IHYPDSTTGD GKPLAADYNG NCSLEKFYDD
     PRSNDGNSYR LQSWLYSSRL LQYSDALEHL LTTGQGVVLE RSIFSDFVFL EAMYNQGFIR
     KQCVDHYNEV KSVTICDYLP PHLVIYIDVP VPEVQRRIQK KGDPHEMKIT SAYLQDIENA
     YKKTFLPEMS EKCEVLQYSA REAQDSKKAV EDIEYLKFDK GPWLKQDNRT LYHLRLLVQD
     KFEVLNYTSI PIFLPEVTIG AHQTDRVLHQ FRELPGRKYS PGYNTEVGDK WIWLK
//
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