ID NDUB6_PONAB Reviewed; 128 AA.
AC P0CB93; Q0MQD9; Q5RBV5;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 1.
DT 22-FEB-2023, entry version 45.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;
DE AltName: Full=Complex I-B17;
DE Short=CI-B17;
DE AltName: Full=NADH-ubiquinone oxidoreductase B17 subunit;
GN Name=NDUFB6;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000250|UniProtKB:O95139}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:O95139}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:O95139}; Single-pass membrane protein
CC {ECO:0000255}; Matrix side {ECO:0000250|UniProtKB:O95139}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB6 subunit family.
CC {ECO:0000305}.
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DR EMBL; CR858528; CAH90755.1; -; mRNA.
DR RefSeq; NP_001125422.1; NM_001131950.2.
DR AlphaFoldDB; P0CB93; -.
DR SMR; P0CB93; -.
DR STRING; 9601.ENSPPYP00000021452; -.
DR GeneID; 100172329; -.
DR KEGG; pon:100172329; -.
DR CTD; 4712; -.
DR eggNOG; KOG4633; Eukaryota.
DR InParanoid; P0CB93; -.
DR OrthoDB; 5382809at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR019174; NADH_DH_b-subcmplx_su6.
DR PANTHER; PTHR15083; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6; 1.
DR PANTHER; PTHR15083:SF0; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6; 1.
DR Pfam; PF09782; NDUF_B6; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O95139"
FT CHAIN 2..128
FT /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
FT subunit 6"
FT /id="PRO_0000118809"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000250|UniProtKB:O95139"
FT MOD_RES 24
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q3UIU2"
SQ SEQUENCE 128 AA; 15551 MW; 961A031EC1BA6AEA CRC64;
MTEYTPDEKL RLHQLRKLRR RWLKDQELSH REPVLPPQKM GPMEKFWNTF LENKSPWRKM
VHGVYQKSIF VFTHILVPAW IIHYYMKYHV SEKPYGIVET KPRIFPGDTI LETGEVIPPM
KEFPDQHH
//
