ID NEUA_HAEIN Reviewed; 228 AA.
AC Q57140; O05051;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Probable N-acylneuraminate cytidylyltransferase;
DE EC=2.7.7.43;
DE AltName: Full=CMP-N-acetylneuraminic acid synthase;
DE Short=CMP-NeuNAc synthase;
DE AltName: Full=CMP-sialic acid synthase;
GN Name=neuA; OrderedLocusNames=HI_1279;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family. {ECO:0000305}.
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DR EMBL; L42023; AAC22927.1; -; Genomic_DNA.
DR PIR; C64114; C64114.
DR RefSeq; NP_439432.1; NC_000907.1.
DR AlphaFoldDB; Q57140; -.
DR SMR; Q57140; -.
DR STRING; 71421.HI_1279; -.
DR EnsemblBacteria; AAC22927; AAC22927; HI_1279.
DR KEGG; hin:HI_1279; -.
DR PATRIC; fig|71421.8.peg.1330; -.
DR eggNOG; COG1083; Bacteria.
DR HOGENOM; CLU_042930_1_0_6; -.
DR OrthoDB; 9805604at2; -.
DR PhylomeDB; Q57140; -.
DR BioCyc; HINF71421:G1GJ1-1304-MONOMER; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IBA:GO_Central.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleotidyltransferase; Reference proteome; Transferase.
FT CHAIN 1..228
FT /note="Probable N-acylneuraminate cytidylyltransferase"
FT /id="PRO_0000213204"
SQ SEQUENCE 228 AA; 25308 MW; B3CC7674CA379551 CRC64;
MKIIMTRIAI IPARAGSKGI KDKNLQLVGG VSLVGRAILA AQESGMFDQI VVTSDGENIL
KEATKYGAKP VARPESLAQS DTRTIDAILH CLETLNISQG TAALLQPTSP LRNALDIRNA
MEIFLGGKYK SVVSACECEH HPYKSFTLEG TEVQPIHELT DFESPRQKLP KSYRANGAIY
INDIQSLFEE KRFFIAPMRF YLMPTYRSID IDSTLDLQLA ESLISKEF
//
