ID NH268_CAEEL Reviewed; 340 AA.
AC O17930;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=Nuclear hormone receptor family member nhr-268;
GN Name=nhr-268; ORFNames=K06B4.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z83233; CAB05763.2; -; Genomic_DNA.
DR PIR; T23367; T23367.
DR RefSeq; NP_506902.2; NM_074501.3.
DR AlphaFoldDB; O17930; -.
DR SMR; O17930; -.
DR BioGRID; 51760; 1.
DR IntAct; O17930; 1.
DR STRING; 6239.K06B4.6.2; -.
DR PaxDb; 6239-K06B4-6-2; -.
DR EnsemblMetazoa; K06B4.6.1; K06B4.6.1; WBGene00010601.
DR GeneID; 187054; -.
DR KEGG; cel:CELE_K06B4.6; -.
DR UCSC; K06B4.6; c. elegans.
DR AGR; WB:WBGene00010601; -.
DR WormBase; K06B4.6; CE42553; WBGene00010601; nhr-268.
DR GeneTree; ENSGT00970000195839; -.
DR HOGENOM; CLU_007368_3_0_1; -.
DR InParanoid; O17930; -.
DR OrthoDB; 3060590at2759; -.
DR PhylomeDB; O17930; -.
DR PRO; PR:O17930; -.
DR Proteomes; UP000001940; Chromosome V.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45886:SF2; NUCLEAR HORMONE RECEPTOR FAMILY-RELATED; 1.
DR PANTHER; PTHR45886; NUCLEAR HORMONE RECEPTOR FAMILY-RELATED-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..340
FT /note="Nuclear hormone receptor family member nhr-268"
FT /id="PRO_0000223608"
FT DOMAIN 98..337
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 1..75
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 3..23
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 39..58
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 340 AA; 39633 MW; AB3B62D5D0BCAE42 CRC64;
MNCLVCSARA FNRNYGVMSC FACKMFFRRT VFKNMLFNCK YFKNCTIHYK THPKCRACRF
QKCLNIGMKA ASKNDRIVSI GNYEDYNFDK LLNDLIVKND KNYSNFIDFY SLEDPSLKDI
IEDRSIMKLV RRTPETLNDV DQWSNMLAYS RISYFLDFNF IRELDSSDKN TLFKYNVSRA
GCLALAMCAY SENKPKLTFP NDVDIFPSEM YNLCGSSTAV LNQVSGQVIA KFIELEIRQE
EYLLLLLVMF CNASITNNFS HKTKLILSSH QQVYCSALFR YCQLKYSKSA PTRFTELLSV
FGIVNKSVNN MSFLSMMVQC YNPKFNFKRL MQDIFSHTLS
//
