ID NK3R_RABIT Reviewed; 467 AA.
AC O97512;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 2.
DT 08-NOV-2023, entry version 102.
DE RecName: Full=Neuromedin-K receptor;
DE Short=NKR;
DE AltName: Full=NK-3 receptor;
DE Short=NK-3R;
DE AltName: Full=Neurokinin B receptor;
DE AltName: Full=Tachykinin receptor 3;
GN Name=TACR3;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=New Zealand white; TISSUE=Iris sphincter muscle;
RX PubMed=10516642; DOI=10.1038/sj.bjp.0702854;
RA Medhurst A.D., Hirst W.D., Jerman J.C., Meakin J., Roberts J.C., Testa T.,
RA Smart D.;
RT "Molecular and pharmacological characterization of a functional tachykinin
RT NK3 receptor cloned from the rabbit iris sphincter muscle.";
RL Br. J. Pharmacol. 128:627-636(1999).
CC -!- FUNCTION: This is a receptor for the tachykinin neuropeptide
CC neuromedin-K (neurokinin B). It is associated with G proteins that
CC activate a phosphatidylinositol-calcium second messenger system (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF133908; AAD01408.2; -; mRNA.
DR RefSeq; NP_001075524.1; NM_001082055.1.
DR AlphaFoldDB; O97512; -.
DR SMR; O97512; -.
DR STRING; 9986.ENSOCUP00000008258; -.
DR GlyCosmos; O97512; 3 sites, No reported glycans.
DR PaxDb; 9986-ENSOCUP00000008258; -.
DR GeneID; 100008721; -.
DR KEGG; ocu:100008721; -.
DR CTD; 6870; -.
DR eggNOG; KOG4219; Eukaryota.
DR InParanoid; O97512; -.
DR OrthoDB; 2912851at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004995; F:tachykinin receptor activity; IEA:InterPro.
DR CDD; cd16003; 7tmA_NKR_NK3R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001681; Neurokn_rcpt.
DR InterPro; IPR001013; NK3_rcpt.
DR PANTHER; PTHR46925; G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED; 1.
DR PANTHER; PTHR46925:SF1; NEUROMEDIN-K RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01026; NEUROKININ3R.
DR PRINTS; PR00244; NEUROKININR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..467
FT /note="Neuromedin-K receptor"
FT /id="PRO_0000069901"
FT TOPO_DOM 1..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..109
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..141
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..183
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..272
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..323
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..336
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..361
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 362..467
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 416..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 376
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 160..235
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 467 AA; 52450 MW; 4FE21F2F86549BAA CRC64;
MDSFAAAETW TDAAGGAGAD GRNLSAALAA GAAAEALGTE WLQLLVQAGN LSSSLPSSVP
GLPTTSPAPS QPRANLTNQF VQPSWRIALW SLAYGVVVAV AVFGNLIVIW IILAHKRMRT
VTNYFLVNLA FSDASMAAFN TLVNFIYALH SEWYFGANYC RFQNFFPITA VFASIYSMTA
IAVDRYMAII DPLKPRLSAT ATKIVIGSIW ILAFLLALPQ CLYSKTKVMP GRTLCYVQWP
EGPKQHFIYH IIVIILVYCF PLLIMGITYT IVGITLWGGE IPGDTCDKYH EQLKAKRKVV
KMMIIVVVTF AICWLPYHIY FILTAIYQQL NRWKYIQQVY LASFWLAMSS TMYNPIIYCC
LNKRFRAGFK RAFRWCPFIQ VSSYDELELK TTRFHPTRQS SLYTVTRMES MTVVFDPSDA
DNTRSSRKKR ATPGDPNFNG CSRRNSKSAS TTSSFISSPY TSMEEYS
//
