ID NORM_THEMA Reviewed; 464 AA.
AC Q9WZS2;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=Probable multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
GN Name=norM; OrderedLocusNames=TM_0815;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AE000512; AAD35897.1; -; Genomic_DNA.
DR PIR; H72331; H72331.
DR RefSeq; NP_228624.1; NC_000853.1.
DR RefSeq; WP_010865209.1; NZ_CP011107.1.
DR AlphaFoldDB; Q9WZS2; -.
DR SMR; Q9WZS2; -.
DR STRING; 243274.TM_0815; -.
DR TCDB; 2.A.66.1.28; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR PaxDb; 243274-THEMA_00575; -.
DR DNASU; 898483; -.
DR EnsemblBacteria; AAD35897; AAD35897; TM_0815.
DR KEGG; tma:TM0815; -.
DR KEGG; tmw:THMA_0834; -.
DR PATRIC; fig|243274.18.peg.112; -.
DR eggNOG; COG0534; Bacteria.
DR InParanoid; Q9WZS2; -.
DR OrthoDB; 9776324at2; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd13137; MATE_NorM_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..464
FT /note="Probable multidrug resistance protein NorM"
FT /id="PRO_0000164243"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 464 AA; 51054 MW; 65DA15D7DE038461 CRC64;
MRYSLFKNYL PKEEVPEIRK ELIKLALPAM GENVLQMLFG MADTAFLGHY SWKAMSGVGL
SNQVFWVVQV VLIAASMGAT VTIANAIGAG NRKAVRSLAW NSVFLAIFTG VILTALTPLS
DVLINIFPNL EGEIESSAKE YLKVILSGSM GFSIMAVFSA MLRGAGDTRT PMIVTGLTNF
LNIFLDYAMI FGKFGFPEMG VRGAAVATIL SRFVGAGILT YVIFKREEFQ LRKGLVPPKW
SSQKEILRVG FPTAIENFVF STGVLMFANI LLIAGAEAYA GHRIGINVES LSFMPAFGIS
VAITTLVGRY NGMGNKEHVL GVIRQGWILS LLFQVTVGII IFLFPEPLIR IFTSDPQIIE
ISKLPVKIIG LFQFFLAIDS TMNGALRGTG NTLPPMIITF ISIWTARLPV AFVMVKYFQL
GLLGAWIGMI ADIIFRSTLK LLFFLSGKWE KRAVLTRERV KELG
//
