ID NQRA_RHOBA Reviewed; 456 AA.
AC Q7UWS5;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 13-SEP-2023, entry version 87.
DE RecName: Full=Na(+)-translocating NADH-quinone reductase subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE Short=Na(+)-translocating NQR subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE EC=7.2.1.1 {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR complex subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
DE AltName: Full=NQR-1 subunit A {ECO:0000255|HAMAP-Rule:MF_00425};
GN Name=nqrA {ECO:0000255|HAMAP-Rule:MF_00425}; OrderedLocusNames=RB1831;
OS Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1).
OC Bacteria; Planctomycetota; Planctomycetia; Pirellulales; Pirellulaceae;
OC Rhodopirellula.
OX NCBI_TaxID=243090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10527 / NCIMB 13988 / SH1;
RX PubMed=12835416; DOI=10.1073/pnas.1431443100;
RA Gloeckner F.O., Kube M., Bauer M., Teeling H., Lombardot T., Ludwig W.,
RA Gade D., Beck A., Borzym K., Heitmann K., Rabus R., Schlesner H., Amann R.,
RA Reinhardt R.;
RT "Complete genome sequence of the marine planctomycete Pirellula sp. strain
RT 1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8298-8303(2003).
CC -!- FUNCTION: NQR complex catalyzes the reduction of ubiquinone-1 to
CC ubiquinol by two successive reactions, coupled with the transport of
CC Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are
CC probably involved in the second step, the conversion of ubisemiquinone
CC to ubiquinol. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n
CC Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565,
CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=7.2.1.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00425};
CC -!- SUBUNIT: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and
CC NqrF. {ECO:0000255|HAMAP-Rule:MF_00425}.
CC -!- SIMILARITY: Belongs to the NqrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00425}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD72287.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX294135; CAD72287.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_864606.1; NC_005027.1.
DR AlphaFoldDB; Q7UWS5; -.
DR SMR; Q7UWS5; -.
DR STRING; 243090.RB1831; -.
DR EnsemblBacteria; CAD72287; CAD72287; RB1831.
DR KEGG; rba:RB1831; -.
DR PATRIC; fig|243090.15.peg.840; -.
DR eggNOG; COG1726; Bacteria.
DR HOGENOM; CLU_046656_0_0_0; -.
DR InParanoid; Q7UWS5; -.
DR OrthoDB; 9774536at2; -.
DR Proteomes; UP000001025; Chromosome.
DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00425; NqrA; 1.
DR InterPro; IPR008703; NqrA.
DR InterPro; IPR022615; NqrA_C_domain.
DR NCBIfam; TIGR01936; nqrA; 1.
DR PANTHER; PTHR37839; NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A; 1.
DR PANTHER; PTHR37839:SF1; NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT A; 1.
DR Pfam; PF05896; NQRA; 1.
DR Pfam; PF11973; NQRA_SLBB; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Reference proteome; Sodium; Sodium transport;
KW Translocase; Transport; Ubiquinone.
FT CHAIN 1..456
FT /note="Na(+)-translocating NADH-quinone reductase subunit
FT A"
FT /id="PRO_0000227020"
SQ SEQUENCE 456 AA; 49195 MW; 4B016F907FF0FB47 CRC64;
MATTQSVTRI KKGLDLPITG CPEQHMEAGP AIRQVALLGD DYIGMKPTML VSAGDRVVLG
QPVFEDKKTP GVIYTAPASG TVVDVVRGAK RKFEAVVIDV DNDSTETTTI DGIAGSDPIS
IAREKLVDGL VQIGLWSAFR TRPFGKVPTI ESRPHSIFVT AIDTNPLAAD PAVVLADRKD
QFVIGLQALT RLTDGAVHLC QAEKASIPGG DVAGVQSASF AGPHPAGLPG THIHHLDPVS
LNKTVWYIGY QDVIAIGSFL QTGQLDTRRV ISLAGPKVNQ PRLIETRLGA CIDELIDGEV
DTSVKLRVIS GSVLNGHIAT APHQFLGRYD NQVSVIEEGD HREFLGWQKP GFDKFSVSRI
FASAMTPDRK FDFTSSTGGS ERAMVPLGTY EKVMPMDILA TQLLRALIVR DTDSAQQLGV
LELEEEDLAL CTFVCPGKYE YGSLIRENLT TIEREG
//
