ID NR0B1_PANTR Reviewed; 470 AA.
AC Q9BG97;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=Nuclear receptor subfamily 0 group B member 1;
DE AltName: Full=Nuclear receptor DAX-1;
GN Name=NR0B1; Synonyms=DAX1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11112659; DOI=10.1086/316932;
RA Patel M., Dorman K.S., Zhang Y.-H., Huang B.-L., Arnold A.P.,
RA Sinsheimer J.S., Vilain E., McCabe E.R.B.;
RT "Primate DAX1, SRY, and SOX9: evolutionary stratification of sex-
RT determination pathway.";
RL Am. J. Hum. Genet. 68:275-280(2001).
CC -!- FUNCTION: Orphan nuclear receptor. Component of a cascade required for
CC the development of the hypothalamic-pituitary-adrenal-gonadal axis.
CC Acts as a coregulatory protein that inhibits the transcriptional
CC activity of other nuclear receptors through heterodimeric interactions.
CC May also have a role in the development of the embryo and in the
CC maintenance of embryonic stem cell pluripotency (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2
CC (By similarity). Interacts with ESRRB; represses ESRRB activity at the
CC GATA6 promoter (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q61066}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in
CC the cytoplasm and in the nucleus (By similarity). {ECO:0000250}.
CC -!- DOMAIN: Homodimerization involved an interaction between amino and
CC carboxy termini involving LXXLL motifs and steroid binding domain (AF-2
CC motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal
CC LXXLL motifs (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
CC subfamily. {ECO:0000305}.
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DR EMBL; AF322892; AAK01643.1; -; mRNA.
DR AlphaFoldDB; Q9BG97; -.
DR SMR; Q9BG97; -.
DR STRING; 9598.ENSPTRP00000047467; -.
DR PaxDb; 9598-ENSPTRP00000047467; -.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q9BG97; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005840; C:ribosome; ISS:UniProtKB.
DR GO; GO:0032448; F:DNA hairpin binding; ISS:UniProtKB.
DR GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR GO; GO:0019904; F:protein domain specific binding; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0030325; P:adrenal gland development; ISS:UniProtKB.
DR GO; GO:0008406; P:gonad development; ISS:UniProtKB.
DR GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISS:UniProtKB.
DR GO; GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0010894; P:negative regulation of steroid biosynthetic process; ISS:HGNC-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR CDD; cd07350; NR_LBD_Dax1; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR033544; NR0B1/2.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR025900; Nuclear_receptor_repeat.
DR PANTHER; PTHR24081; NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B; 1.
DR PANTHER; PTHR24081:SF1; NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF14046; NR_Repeat; 4.
DR PRINTS; PR00398; STRDHORMONER.
DR SMART; SM00430; HOLI; 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Receptor; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..470
FT /note="Nuclear receptor subfamily 0 group B member 1"
FT /id="PRO_0000280117"
FT REPEAT 1..67
FT /note="1"
FT REPEAT 68..133
FT /note="2"
FT REPEAT 134..200
FT /note="3"
FT REPEAT 201..253
FT /note="4; truncated"
FT DOMAIN 205..469
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT REGION 1..253
FT /note="4 X 67 AA tandem repeats"
FT MOTIF 13..17
FT /note="LXXLL motif 1"
FT MOTIF 80..84
FT /note="LXXLL motif 2"
FT MOTIF 146..150
FT /note="LXXLL motif 3"
FT MOTIF 461..466
FT /note="AF-2 motif"
SQ SEQUENCE 470 AA; 51711 MW; D64B967E6AF7D76E CRC64;
MAGENHQWQG SILYNMLMSA KQTRAAPEAP ETRLVDQCWG CSCGDEPGVG REGLLGGRNV
ALLYRCCFCG KDHPRQGSIL YSMLTSAKQT YAAPKAPEAT LGPCWGCSCG SDPGVGRTGL
PGGRPVALLY RCCFCGENHP RQGSILYSLL TSSKQTHVAP AAPEARPGGA WWDRSYFAQK
PGGKEALPGG RATALLYRCC FCGEDHPQQG STLYCMPTST NQAQAAPEER PRAPWWDTSS
GALRPVALKS PQVVCEAASA GLLKTLRFVK YLPCFQVLPL DQQLVLVRNC WASLLMLELA
QDRLQFETVE VSEPSMLQKI LTTRRRETGG NEPLPVPTLQ PHLAPPAEAR KVPSASQVQA
IKCFLSKCWS LNISTKEYAY LKGTVLFNPD VPGLQCVKYI QGLQWGTQQI LSEHTRMTHQ
GPHDRFIELN STLFLLRFIN ANVIAELFFR PIIGTVSMDD MMLEMLCTKI
//
