ID NSRR_BACLD Reviewed; 143 AA.
AC Q65M01; Q62XD8;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=HTH-type transcriptional regulator NsrR;
GN Name=nsrR; OrderedLocusNames=BLi01005, BL02858;
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15383718; DOI=10.1159/000079829;
RA Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT with great industrial potential.";
RL J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- FUNCTION: Nitric oxide-responsive transcriptional regulator.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000305};
CC Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000305};
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DR EMBL; AE017333; AAU39913.3; -; Genomic_DNA.
DR EMBL; CP000002; AAU22570.1; -; Genomic_DNA.
DR RefSeq; WP_003180105.1; NC_006322.1.
DR AlphaFoldDB; Q65M01; -.
DR SMR; Q65M01; -.
DR STRING; 279010.BL02858; -.
DR GeneID; 66216866; -.
DR KEGG; bld:BLi01005; -.
DR KEGG; bli:BL02858; -.
DR eggNOG; COG1959; Bacteria.
DR HOGENOM; CLU_107144_2_1_9; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR030489; TR_Rrf2-type_CS.
DR InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00738; rrf2_super; 1.
DR PANTHER; PTHR33221:SF4; HTH-TYPE TRANSCRIPTIONAL REPRESSOR NSRR; 1.
DR PANTHER; PTHR33221; WINGED HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, RRF2 FAMILY; 1.
DR Pfam; PF02082; Rrf2; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01332; HTH_RRF2_1; 1.
DR PROSITE; PS51197; HTH_RRF2_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..143
FT /note="HTH-type transcriptional regulator NsrR"
FT /id="PRO_0000271133"
FT DOMAIN 2..133
FT /note="HTH rrf2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT DNA_BIND 28..51
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 92
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 100
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 106
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
SQ SEQUENCE 143 AA; 16280 MW; 81CBC28EEC12851E CRC64;
MKLTNYTDYS LRVLIFLATK NSNELVNIKD IADSYSISKN HLMKVIYELG KLGYVETIRG
RNGGIRLGKA PELINIGEVI RHTEDDFNLV ECFNGEKNHC ILSPICGLKH VLNKALSAYL
DVLDQYTLQD IIMNQDHIRK LLS
//
