ID NTF3_CHICK Reviewed; 257 AA.
AC P25433; Q6LAC6;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 2.
DT 27-MAR-2024, entry version 143.
DE RecName: Full=Neurotrophin-3;
DE Short=NT-3;
DE AltName: Full=HDNF;
DE AltName: Full=Nerve growth factor 2;
DE Short=NGF-2;
DE AltName: Full=Neurotrophic factor;
DE Flags: Precursor;
GN Name=NTF3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1457809; DOI=10.3109/10425179209039695;
RA Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.;
RT "Gene sequences of chicken BDNF and NT-3.";
RL DNA Seq. 3:49-54(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-257.
RX PubMed=8074744; DOI=10.1111/j.1460-9568.1993.tb00199.x;
RA Hallboeoek F., Ibanez C.F., Ebendal T., Persson H.;
RT "Cellular localization of brain-derived neurotrophic factor and
RT neurotrophin-3 mRNA expression in the early chicken embryo.";
RL Eur. J. Neurosci. 5:1-14(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-236.
RX PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA Hallboeoek F., Ibanez C.F., Persson H.;
RT "Evolutionary studies of the nerve growth factor family reveal a novel
RT member abundantly expressed in Xenopus ovary.";
RL Neuron 6:845-858(1991).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: In the embryo, the expression peak at E4.5 and
CC decreases at later stages of development.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; M83378; AAA68880.1; -; Genomic_DNA.
DR EMBL; Z30092; CAA82908.1; -; Genomic_DNA.
DR PIR; I50400; I50400.
DR RefSeq; NP_001026659.1; NM_001031488.1.
DR AlphaFoldDB; P25433; -.
DR SMR; P25433; -.
DR STRING; 9031.ENSGALP00000070337; -.
DR GlyCosmos; P25433; 1 site, No reported glycans.
DR PaxDb; 9031-ENSGALP00000043385; -.
DR Ensembl; ENSGALT00010059737.1; ENSGALP00010036497.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00010059739.1; ENSGALP00010036499.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00010059745.1; ENSGALP00010036505.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00010059749.1; ENSGALP00010036509.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00010059755.1; ENSGALP00010036515.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00010059756.1; ENSGALP00010036516.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00010059757.1; ENSGALP00010036517.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00010059758.1; ENSGALP00010036518.1; ENSGALG00010024492.1.
DR Ensembl; ENSGALT00015021370; ENSGALP00015011967; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021373; ENSGALP00015011970; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021380; ENSGALP00015011975; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021382; ENSGALP00015011977; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021384; ENSGALP00015011978; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021386; ENSGALP00015011979; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021388; ENSGALP00015011981; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021390; ENSGALP00015011983; ENSGALG00015008872.
DR Ensembl; ENSGALT00015021394; ENSGALP00015011986; ENSGALG00015008872.
DR GeneID; 428099; -.
DR KEGG; gga:428099; -.
DR CTD; 4908; -.
DR VEuPathDB; HostDB:geneid_428099; -.
DR eggNOG; ENOG502R4FK; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_1_1_1; -.
DR InParanoid; P25433; -.
DR OMA; ILLYVMF; -.
DR PhylomeDB; P25433; -.
DR TreeFam; TF106463; -.
DR PRO; PR:P25433; -.
DR Proteomes; UP000000539; Chromosome 1.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..138
FT /id="PRO_0000019665"
FT CHAIN 139..257
FT /note="Neurotrophin-3"
FT /id="PRO_0000019666"
FT CARBOHYD 131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 152..217
FT /evidence="ECO:0000250"
FT DISULFID 195..246
FT /evidence="ECO:0000250"
FT DISULFID 205..248
FT /evidence="ECO:0000250"
SQ SEQUENCE 257 AA; 29701 MW; EE043BA2A005C1E7 CRC64;
MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK QVMDVKENYQ
NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN SPRVLLSDNT PLEPPPLYLT
EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK
TGNSPVKQYF YETRCKEAKP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI
RIDTSCVCAL SRKIGRT
//
