ID NTF4_MOUSE Reviewed; 209 AA.
AC Q80VU4;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 24-JAN-2024, entry version 132.
DE RecName: Full=Neurotrophin-4;
DE Short=NT-4;
DE AltName: Full=Neurotrophin-5;
DE Short=NT-5;
DE AltName: Full=Neutrophic factor 4;
DE Flags: Precursor;
GN Name=Ntf4; Synonyms=Ntf5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could serve as a target-derived trophic factor for sensory
CC and sympathetic neurons. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; BC052191; AAH52191.1; -; mRNA.
DR CCDS; CCDS21241.1; -.
DR RefSeq; NP_937833.1; NM_198190.1.
DR RefSeq; XP_006541375.1; XM_006541312.3.
DR RefSeq; XP_006541376.1; XM_006541313.2.
DR RefSeq; XP_011249221.1; XM_011250919.2.
DR AlphaFoldDB; Q80VU4; -.
DR SMR; Q80VU4; -.
DR STRING; 10090.ENSMUSP00000057916; -.
DR GlyCosmos; Q80VU4; 1 site, No reported glycans.
DR GlyGen; Q80VU4; 1 site.
DR PhosphoSitePlus; Q80VU4; -.
DR PaxDb; 10090-ENSMUSP00000057916; -.
DR Antibodypedia; 65111; 705 antibodies from 43 providers.
DR DNASU; 78405; -.
DR Ensembl; ENSMUST00000058879.8; ENSMUSP00000057916.7; ENSMUSG00000074121.4.
DR GeneID; 78405; -.
DR KEGG; mmu:78405; -.
DR UCSC; uc009gva.1; mouse.
DR AGR; MGI:97381; -.
DR CTD; 78405; -.
DR MGI; MGI:97381; Ntf5.
DR VEuPathDB; HostDB:ENSMUSG00000074121; -.
DR eggNOG; ENOG502R4FK; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_2_1_1; -.
DR InParanoid; Q80VU4; -.
DR OMA; HWISECK; -.
DR OrthoDB; 5399313at2759; -.
DR PhylomeDB; Q80VU4; -.
DR TreeFam; TF106463; -.
DR Reactome; R-MMU-9026527; Activated NTRK2 signals through PLCG1.
DR Reactome; R-MMU-9028731; Activated NTRK2 signals through FRS2 and FRS3.
DR BioGRID-ORCS; 78405; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Ntf5; mouse.
DR PRO; PR:Q80VU4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80VU4; Protein.
DR Bgee; ENSMUSG00000074121; Expressed in manus and 111 other cell types or tissues.
DR ExpressionAtlas; Q80VU4; baseline and differential.
DR Genevisible; Q80VU4; MM.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0005166; F:neurotrophin p75 receptor binding; TAS:MGI.
DR GO; GO:0008344; P:adult locomotory behavior; IMP:MGI.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0007402; P:ganglion mother cell fate determination; IMP:MGI.
DR GO; GO:0060384; P:innervation; IDA:MGI.
DR GO; GO:0007616; P:long-term memory; IMP:MGI.
DR GO; GO:0042490; P:mechanoreceptor differentiation; IGI:MGI.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0043069; P:negative regulation of programmed cell death; IDA:MGI.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0008052; P:sensory organ boundary specification; IMP:MGI.
DR GO; GO:0061193; P:taste bud development; IDA:MGI.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR020432; Neurotrophin-4.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF8; NEUROTROPHIN-4; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01915; NEUROTROPHN4.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..79
FT /id="PRO_0000019671"
FT CHAIN 80..209
FT /note="Neurotrophin-4"
FT /id="PRO_0000019672"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..169
FT /evidence="ECO:0000250"
FT DISULFID 140..198
FT /evidence="ECO:0000250"
FT DISULFID 157..200
FT /evidence="ECO:0000250"
SQ SEQUENCE 209 AA; 22346 MW; 797AE81A2A33EAB6 CRC64;
MLPRHSCSLL LFLFLLPSVP MEPHPPSSTL PPFLAPEWDL LSPRVALSRG APAGPPLLFL
LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS GWVTDRRTAV DLRGREVEVL
GEVPAAGGSP LRQYFFETRC KAESAGEGGP GVGGGGCRGV DRRHWLSECK AKQSYVRALT
ADSQGRVGWR WIRIDTACVC TLLSRTGRA
//
