ID NU6M_HUMAN Reviewed; 174 AA.
AC P03923; Q34774; Q8HG30;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 27-MAR-2024, entry version 206.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000269|PubMed:14595656, ECO:0000269|PubMed:8644732};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Homo sapiens (Human).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7219534; DOI=10.1038/290457a0;
RA Anderson S., Bankier A.T., Barrell B.G., de Bruijn M.H.L., Coulson A.R.,
RA Drouin J., Eperon I.C., Nierlich D.P., Roe B.A., Sanger F., Schreier P.H.,
RA Smith A.J.H., Staden R., Young I.G.;
RT "Sequence and organization of the human mitochondrial genome.";
RL Nature 290:457-465(1981).
RN [2]
RP SEQUENCE REVISION TO 102; 134 AND 159.
RA Kogelnik A., Brown M.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Placenta;
RX PubMed=7530363; DOI=10.1073/pnas.92.2.532;
RA Horai S., Hayasaka K., Kondo R., Tsugane K., Takahata N.;
RT "Recent African origin of modern humans revealed by complete sequences of
RT hominoid mitochondrial DNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LHON VAL-64.
RX PubMed=9452107; DOI=10.1002/humu.1380110186;
RA Sudoyo H., Sitepu M., Malik S., Poesponegoro H.D., Marzuki S.;
RT "Leber's hereditary optic neuropathy in Indonesia: two families with the
RT mtDNA 11778G>A and 14484T>C mutations.";
RL Hum. Mutat. Suppl. 1:S271-S274(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12949126; DOI=10.1093/molbev/msg230;
RA Moilanen J.S., Finnila S., Majamaa K.;
RT "Lineage-specific selection in human mtDNA: lack of polymorphisms in a
RT segment of MTND5 gene in haplogroup J.";
RL Mol. Biol. Evol. 20:2132-2142(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11130070; DOI=10.1038/35047064;
RA Ingman M., Kaessmann H., Paeaebo S., Gyllensten U.;
RT "Mitochondrial genome variation and the origin of modern humans.";
RL Nature 408:708-713(2000).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12840039; DOI=10.1101/gr.686603;
RA Ingman M., Gyllensten U.;
RT "Mitochondrial genome variation and evolutionary history of Australian and
RT New Guinean aborigines.";
RL Genome Res. 13:1600-1606(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14760490; DOI=10.1007/s00414-004-0427-6;
RA Coble M.D., Just R.S., O'Callaghan J.E., Letmanyi I.H., Peterson C.T.,
RA Irwin J.A., Parsons T.J.;
RT "Single nucleotide polymorphisms over the entire mtDNA genome that increase
RT the power of forensic testing in Caucasians.";
RL Int. J. Legal Med. 118:137-146(2004).
RN [9]
RP VARIANT VAL-58.
RX PubMed=2043137; DOI=10.1016/0006-291x(91)92014-b;
RA Ozawa T., Tanaka M., Sugiyama S., Ino H., Ohno K., Hattori K.,
RA Ohbayashi T., Ito T., Deguchi H., Kawamura K., Nakane Y., Hashiba K.;
RT "Patients with idiopathic cardiomyopathy belong to the same mitochondrial
RT DNA gene family of Parkinson's disease and mitochondrial
RT encephalomyopathy.";
RL Biochem. Biophys. Res. Commun. 177:518-525(1991).
RN [10]
RP VARIANT CYS-165.
RX PubMed=1757091; DOI=10.1007/bf00206061;
RA Marzuki S., Noer A.S., Lertrit P., Thyagarajan D., Kapsa R.,
RA Utthanaphol P., Byrne E.;
RT "Normal variants of human mitochondrial DNA and translation products: the
RT building of a reference data base.";
RL Hum. Genet. 88:139-145(1991).
RN [11]
RP VARIANT LHON VAL-64.
RX PubMed=1417830; DOI=10.1016/0006-291x(92)90479-5;
RA Johns D.R., Neufeld M.J., Park R.D.;
RT "An ND-6 mitochondrial DNA mutation associated with Leber hereditary optic
RT neuropathy.";
RL Biochem. Biophys. Res. Commun. 187:1551-1557(1992).
RN [12]
RP VARIANT LDYT VAL-72.
RX PubMed=8016139; DOI=10.1073/pnas.91.13.6206;
RA Jun A.S., Brown M.D., Wallace D.C.;
RT "A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH
RT dehydrogenase subunit 6 gene associated with maternally inherited Leber
RT hereditary optic neuropathy and dystonia.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:6206-6210(1994).
RN [13]
RP VARIANT LDYT MET-26, CHARACTERIZATION OF VARIANT LDYT MET-26, FUNCTION, AND
RP CATALYTIC ACTIVITY.
RX PubMed=8644732;
RA de Vries D.D., Went L.N., Bruyn G.W., Scholte H.R., Hofstra R.M.W.,
RA Bolhuis P.A., van Oost B.A.;
RT "Genetic and biochemical impairment of mitochondrial complex I activity in
RT a family with Leber hereditary optic neuropathy and hereditary spastic
RT dystonia.";
RL Am. J. Hum. Genet. 58:703-711(1996).
RN [14]
RP VARIANT LHON CYS-59.
RX PubMed=8854108;
RA Leo-Kottler B., Christ-Adler M., Baumann B., Zrenner E., Wissinger B.;
RT "Leber's hereditary optic neuropathy: clinical and molecular genetic
RT results obtained in a family with a new point mutation at nucleotide
RT position 14498 in the ND 6 gene.";
RL Ger. J. Ophthalmol. 5:233-240(1996).
RN [15]
RP VARIANT LHON SER-36.
RX PubMed=10447650; DOI=10.1007/s004170050307;
RA Besch D., Leo-Kottler B., Zrenner E., Wissinger B.;
RT "Leber's hereditary optic neuropathy: clinical and molecular genetic
RT findings in a patient with a new mutation in the ND6 gene.";
RL Graefes Arch. Clin. Exp. Ophthalmol. 237:745-752(1999).
RN [16]
RP VARIANT LHON SER-60, AND VARIANTS ALA-31 AND VAL-33.
RX PubMed=11133798; DOI=10.1093/brain/124.1.209;
RA Chinnery P.F., Brown D.T., Andrews R.M., Singh-Kler R., Riordan-Eva P.,
RA Lindley J., Applegarth D.A., Turnbull D.M., Howell N.;
RT "The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's
RT hereditary optic neuropathy.";
RL Brain 124:209-218(2001).
RN [17]
RP VARIANT MELAS VAL-74.
RX PubMed=11781695; DOI=10.1038/sj.ejhg.5200712;
RA Ravn K., Wibrand F., Hansen F.J., Horn N., Rosenberg T., Schwartz M.;
RT "An mtDNA mutation, 14453G-->A, in the NADH dehydrogenase subunit 6
RT associated with severe MELAS syndrome.";
RL Eur. J. Hum. Genet. 9:805-809(2001).
RN [18]
RP VARIANT LS VAL-63, CHARACTERIZATION OF LS VAL-63, FUNCTION, AND CATALYTIC
RP ACTIVITY.
RX PubMed=14595656; DOI=10.1002/ana.10734;
RA Ugalde C., Triepels R.H., Coenen M.J., van den Heuvel L.P., Smeets R.,
RA Uusimaa J., Briones P., Campistol J., Majamaa K., Smeitink J.A.,
RA Nijtmans L.G.;
RT "Impaired complex I assembly in a Leigh syndrome patient with a novel
RT missense mutation in the ND6 gene.";
RL Ann. Neurol. 54:665-669(2003).
RN [19]
RP CHARACTERIZATION OF VARIANT LHON VAL-64.
RX PubMed=35567411; DOI=10.1093/hmg/ddac109;
RA Liang M., Ji C., Zhang L., Wang X., Hu C., Zhang J., Zhu Y., Mo J.Q.,
RA Guan M.X.;
RT "Leber's hereditary optic neuropathy (LHON)-associated ND6 14 484 T > C
RT mutation caused pleiotropic effects on the complex I, RNA homeostasis,
RT apoptosis and mitophagy.";
RL Hum. Mol. Genet. 0:0-0(2022).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor (PubMed:8644732, PubMed:14595656). Essential for the catalytic
CC activity and assembly of complex I (PubMed:8644732, PubMed:14595656).
CC {ECO:0000269|PubMed:14595656, ECO:0000269|PubMed:8644732}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000269|PubMed:14595656, ECO:0000269|PubMed:8644732};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISEASE: Leber hereditary optic neuropathy (LHON) [MIM:535000]: A
CC maternally inherited form of Leber hereditary optic neuropathy, a
CC mitochondrial disease resulting in bilateral painless loss of central
CC vision due to selective degeneration of the retinal ganglion cells and
CC their axons. The disorder shows incomplete penetrance and male
CC predominance. Cardiac conduction defects and neurological defects have
CC also been described in some LHON patients. LHON results from primary
CC mitochondrial DNA mutations affecting the respiratory chain complexes.
CC {ECO:0000269|PubMed:10447650, ECO:0000269|PubMed:11133798,
CC ECO:0000269|PubMed:1417830, ECO:0000269|PubMed:35567411,
CC ECO:0000269|PubMed:8854108, ECO:0000269|PubMed:9452107}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- DISEASE: Leber hereditary optic neuropathy with dystonia (LDYT)
CC [MIM:500001]: A form of Leber hereditary optic neuropathy, a
CC mitochondrial disease resulting in bilateral painless loss of central
CC vision due to selective degeneration of the retinal ganglion cells and
CC their axons. The disorder shows incomplete penetrance and male
CC predominance. LDYT is characterized by the association of optic atrophy
CC and central vision loss with dystonia. {ECO:0000269|PubMed:8016139,
CC ECO:0000269|PubMed:8644732}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Mitochondrial encephalomyopathy with lactic acidosis and
CC stroke-like episodes syndrome (MELAS) [MIM:540000]: Genetically
CC heterogeneous disorder, characterized by episodic vomiting, seizures,
CC and recurrent cerebral insults resembling strokes and causing
CC hemiparesis, hemianopsia, or cortical blindness.
CC {ECO:0000269|PubMed:11781695}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Leigh syndrome (LS) [MIM:256000]: An early-onset progressive
CC neurodegenerative disorder characterized by the presence of focal,
CC bilateral lesions in one or more areas of the central nervous system
CC including the brainstem, thalamus, basal ganglia, cerebellum and spinal
CC cord. Clinical features depend on which areas of the central nervous
CC system are involved and include subacute onset of psychomotor
CC retardation, hypotonia, ataxia, weakness, vision loss, eye movement
CC abnormalities, seizures, and dysphagia. {ECO:0000269|PubMed:14595656}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; J01415; AAB58954.1; -; Genomic_DNA.
DR EMBL; V00662; CAA24037.1; -; Genomic_DNA.
DR EMBL; D38112; BAA07298.1; -; Genomic_DNA.
DR EMBL; AY063322; AAL47640.1; -; Genomic_DNA.
DR EMBL; AY339402; AAP89047.1; -; Genomic_DNA.
DR EMBL; AY339403; AAP89060.1; -; Genomic_DNA.
DR EMBL; AY339404; AAP89073.1; -; Genomic_DNA.
DR EMBL; AY339405; AAP89086.1; -; Genomic_DNA.
DR EMBL; AY339406; AAP89099.1; -; Genomic_DNA.
DR EMBL; AY339407; AAP89112.1; -; Genomic_DNA.
DR EMBL; AY339408; AAP89125.1; -; Genomic_DNA.
DR EMBL; AY339409; AAP89138.1; -; Genomic_DNA.
DR EMBL; AY339410; AAP89151.1; -; Genomic_DNA.
DR EMBL; AY339411; AAP89164.1; -; Genomic_DNA.
DR EMBL; AY339413; AAP89190.1; -; Genomic_DNA.
DR EMBL; AY339414; AAP89203.1; -; Genomic_DNA.
DR EMBL; AY339415; AAP89216.1; -; Genomic_DNA.
DR EMBL; AY339416; AAP89229.1; -; Genomic_DNA.
DR EMBL; AY339417; AAP89242.1; -; Genomic_DNA.
DR EMBL; AY339418; AAP89255.1; -; Genomic_DNA.
DR EMBL; AY339419; AAP89268.1; -; Genomic_DNA.
DR EMBL; AY339420; AAP89281.1; -; Genomic_DNA.
DR EMBL; AY339421; AAP89294.1; -; Genomic_DNA.
DR EMBL; AY339422; AAP89307.1; -; Genomic_DNA.
DR EMBL; AY339423; AAP89320.1; -; Genomic_DNA.
DR EMBL; AY339424; AAP89333.1; -; Genomic_DNA.
DR EMBL; AY339425; AAP89346.1; -; Genomic_DNA.
DR EMBL; AY339426; AAP89359.1; -; Genomic_DNA.
DR EMBL; AY339427; AAP89372.1; -; Genomic_DNA.
DR EMBL; AY339428; AAP89385.1; -; Genomic_DNA.
DR EMBL; AY339429; AAP89398.1; -; Genomic_DNA.
DR EMBL; AY339430; AAP89411.1; -; Genomic_DNA.
DR EMBL; AY339431; AAP89424.1; -; Genomic_DNA.
DR EMBL; AY339432; AAP89437.1; -; Genomic_DNA.
DR EMBL; AY339433; AAP89450.1; -; Genomic_DNA.
DR EMBL; AY339434; AAP89463.1; -; Genomic_DNA.
DR EMBL; AY339435; AAP89476.1; -; Genomic_DNA.
DR EMBL; AY339436; AAP89489.1; -; Genomic_DNA.
DR EMBL; AY339437; AAP89502.1; -; Genomic_DNA.
DR EMBL; AY339438; AAP89515.1; -; Genomic_DNA.
DR EMBL; AY339439; AAP89528.1; -; Genomic_DNA.
DR EMBL; AY339440; AAP89541.1; -; Genomic_DNA.
DR EMBL; AY339441; AAP89554.1; -; Genomic_DNA.
DR EMBL; AY339442; AAP89567.1; -; Genomic_DNA.
DR EMBL; AY339443; AAP89580.1; -; Genomic_DNA.
DR EMBL; AY339444; AAP89593.1; -; Genomic_DNA.
DR EMBL; AY339445; AAP89606.1; -; Genomic_DNA.
DR EMBL; AY339446; AAP89619.1; -; Genomic_DNA.
DR EMBL; AY339447; AAP89632.1; -; Genomic_DNA.
DR EMBL; AY339448; AAP89645.1; -; Genomic_DNA.
DR EMBL; AY339449; AAP89658.1; -; Genomic_DNA.
DR EMBL; AY339450; AAP89671.1; -; Genomic_DNA.
DR EMBL; AY339455; AAP89736.1; -; Genomic_DNA.
DR EMBL; AY339456; AAP89749.1; -; Genomic_DNA.
DR EMBL; AY339457; AAP89762.1; -; Genomic_DNA.
DR EMBL; AY339458; AAP89775.1; -; Genomic_DNA.
DR EMBL; AY339459; AAP89788.1; -; Genomic_DNA.
DR EMBL; AY339460; AAP89801.1; -; Genomic_DNA.
DR EMBL; AY339461; AAP89814.1; -; Genomic_DNA.
DR EMBL; AY339462; AAP89827.1; -; Genomic_DNA.
DR EMBL; AY339463; AAP89840.1; -; Genomic_DNA.
DR EMBL; AY339464; AAP89853.1; -; Genomic_DNA.
DR EMBL; AY339465; AAP89866.1; -; Genomic_DNA.
DR EMBL; AY339466; AAP89879.1; -; Genomic_DNA.
DR EMBL; AY339467; AAP89892.1; -; Genomic_DNA.
DR EMBL; AY339468; AAP89905.1; -; Genomic_DNA.
DR EMBL; AY339469; AAP89918.1; -; Genomic_DNA.
DR EMBL; AY339470; AAP89931.1; -; Genomic_DNA.
DR EMBL; AY339471; AAP89944.1; -; Genomic_DNA.
DR EMBL; AY339472; AAP89957.1; -; Genomic_DNA.
DR EMBL; AY339473; AAP89970.1; -; Genomic_DNA.
DR EMBL; AY339474; AAP89983.1; -; Genomic_DNA.
DR EMBL; AY339475; AAP89996.1; -; Genomic_DNA.
DR EMBL; AY339476; AAP90009.1; -; Genomic_DNA.
DR EMBL; AY339477; AAP90022.1; -; Genomic_DNA.
DR EMBL; AY339478; AAP90035.1; -; Genomic_DNA.
DR EMBL; AY339479; AAP90048.1; -; Genomic_DNA.
DR EMBL; AY339480; AAP90061.1; -; Genomic_DNA.
DR EMBL; AY339481; AAP90074.1; -; Genomic_DNA.
DR EMBL; AY339482; AAP90087.1; -; Genomic_DNA.
DR EMBL; AY339483; AAP90100.1; -; Genomic_DNA.
DR EMBL; AY339484; AAP90113.1; -; Genomic_DNA.
DR EMBL; AY339485; AAP90126.1; -; Genomic_DNA.
DR EMBL; AY339486; AAP90139.1; -; Genomic_DNA.
DR EMBL; AY339487; AAP90152.1; -; Genomic_DNA.
DR EMBL; AY339488; AAP90165.1; -; Genomic_DNA.
DR EMBL; AY339489; AAP90178.1; -; Genomic_DNA.
DR EMBL; AY339490; AAP90191.1; -; Genomic_DNA.
DR EMBL; AY339491; AAP90204.1; -; Genomic_DNA.
DR EMBL; AY339492; AAP90217.1; -; Genomic_DNA.
DR EMBL; AY339493; AAP90230.1; -; Genomic_DNA.
DR EMBL; AY339494; AAP90243.1; -; Genomic_DNA.
DR EMBL; AY339495; AAP90256.1; -; Genomic_DNA.
DR EMBL; AY339496; AAP90269.1; -; Genomic_DNA.
DR EMBL; AY339497; AAP90282.1; -; Genomic_DNA.
DR EMBL; AY339498; AAP90295.1; -; Genomic_DNA.
DR EMBL; AY339499; AAP90308.1; -; Genomic_DNA.
DR EMBL; AY339500; AAP90321.1; -; Genomic_DNA.
DR EMBL; AY339501; AAP90334.1; -; Genomic_DNA.
DR EMBL; AY339502; AAP90347.1; -; Genomic_DNA.
DR EMBL; AY339503; AAP90360.1; -; Genomic_DNA.
DR EMBL; AY339504; AAP90373.1; -; Genomic_DNA.
DR EMBL; AY339505; AAP90386.1; -; Genomic_DNA.
DR EMBL; AY339506; AAP90399.1; -; Genomic_DNA.
DR EMBL; AY339507; AAP90412.1; -; Genomic_DNA.
DR EMBL; AY339508; AAP90425.1; -; Genomic_DNA.
DR EMBL; AY339509; AAP90438.1; -; Genomic_DNA.
DR EMBL; AY339510; AAP90451.1; -; Genomic_DNA.
DR EMBL; AY339511; AAP90464.1; -; Genomic_DNA.
DR EMBL; AY339512; AAP90477.1; -; Genomic_DNA.
DR EMBL; AY339513; AAP90490.1; -; Genomic_DNA.
DR EMBL; AY339514; AAP90503.1; -; Genomic_DNA.
DR EMBL; AY339515; AAP90516.1; -; Genomic_DNA.
DR EMBL; AY339516; AAP90529.1; -; Genomic_DNA.
DR EMBL; AY339517; AAP90542.1; -; Genomic_DNA.
DR EMBL; AY339518; AAP90555.1; -; Genomic_DNA.
DR EMBL; AY339519; AAP90568.1; -; Genomic_DNA.
DR EMBL; AY339520; AAP90581.1; -; Genomic_DNA.
DR EMBL; AY339521; AAP90594.1; -; Genomic_DNA.
DR EMBL; AY339522; AAP90607.1; -; Genomic_DNA.
DR EMBL; AY339523; AAP90620.1; -; Genomic_DNA.
DR EMBL; AY339524; AAP90633.1; -; Genomic_DNA.
DR EMBL; AY339525; AAP90646.1; -; Genomic_DNA.
DR EMBL; AY339526; AAP90659.1; -; Genomic_DNA.
DR EMBL; AY339528; AAP90685.1; -; Genomic_DNA.
DR EMBL; AY339529; AAP90698.1; -; Genomic_DNA.
DR EMBL; AY339530; AAP90711.1; -; Genomic_DNA.
DR EMBL; AY339531; AAP90724.1; -; Genomic_DNA.
DR EMBL; AY339532; AAP90737.1; -; Genomic_DNA.
DR EMBL; AY339533; AAP90750.1; -; Genomic_DNA.
DR EMBL; AY339534; AAP90763.1; -; Genomic_DNA.
DR EMBL; AY339535; AAP90776.1; -; Genomic_DNA.
DR EMBL; AY339536; AAP90789.1; -; Genomic_DNA.
DR EMBL; AY339537; AAP90802.1; -; Genomic_DNA.
DR EMBL; AY339538; AAP90815.1; -; Genomic_DNA.
DR EMBL; AY339539; AAP90828.1; -; Genomic_DNA.
DR EMBL; AY339540; AAP90841.1; -; Genomic_DNA.
DR EMBL; AY339541; AAP90854.1; -; Genomic_DNA.
DR EMBL; AY339542; AAP90867.1; -; Genomic_DNA.
DR EMBL; AY339543; AAP90880.1; -; Genomic_DNA.
DR EMBL; AY339544; AAP90893.1; -; Genomic_DNA.
DR EMBL; AY339545; AAP90906.1; -; Genomic_DNA.
DR EMBL; AY339546; AAP90919.1; -; Genomic_DNA.
DR EMBL; AY339547; AAP90932.1; -; Genomic_DNA.
DR EMBL; AY339548; AAP90945.1; -; Genomic_DNA.
DR EMBL; AY339549; AAP90958.1; -; Genomic_DNA.
DR EMBL; AY339550; AAP90971.1; -; Genomic_DNA.
DR EMBL; AY339551; AAP90984.1; -; Genomic_DNA.
DR EMBL; AY339552; AAP90997.1; -; Genomic_DNA.
DR EMBL; AY339553; AAP91010.1; -; Genomic_DNA.
DR EMBL; AY339554; AAP91023.1; -; Genomic_DNA.
DR EMBL; AY339555; AAP91036.1; -; Genomic_DNA.
DR EMBL; AY339556; AAP91049.1; -; Genomic_DNA.
DR EMBL; AY339557; AAP91062.1; -; Genomic_DNA.
DR EMBL; AY339558; AAP91075.1; -; Genomic_DNA.
DR EMBL; AY339559; AAP91088.1; -; Genomic_DNA.
DR EMBL; AY339560; AAP91101.1; -; Genomic_DNA.
DR EMBL; AY339561; AAP91114.1; -; Genomic_DNA.
DR EMBL; AY339562; AAP91127.1; -; Genomic_DNA.
DR EMBL; AY339563; AAP91140.1; -; Genomic_DNA.
DR EMBL; AY339564; AAP91153.1; -; Genomic_DNA.
DR EMBL; AY339565; AAP91166.1; -; Genomic_DNA.
DR EMBL; AY339566; AAP91179.1; -; Genomic_DNA.
DR EMBL; AY339567; AAP91192.1; -; Genomic_DNA.
DR EMBL; AY339568; AAP91205.1; -; Genomic_DNA.
DR EMBL; AY339569; AAP91218.1; -; Genomic_DNA.
DR EMBL; AY339570; AAP91231.1; -; Genomic_DNA.
DR EMBL; AY339571; AAP91244.1; -; Genomic_DNA.
DR EMBL; AY339572; AAP91257.1; -; Genomic_DNA.
DR EMBL; AY339573; AAP91270.1; -; Genomic_DNA.
DR EMBL; AY339574; AAP91283.1; -; Genomic_DNA.
DR EMBL; AY339575; AAP91296.1; -; Genomic_DNA.
DR EMBL; AY339576; AAP91309.1; -; Genomic_DNA.
DR EMBL; AY339577; AAP91322.1; -; Genomic_DNA.
DR EMBL; AY339578; AAP91335.1; -; Genomic_DNA.
DR EMBL; AY339579; AAP91348.1; -; Genomic_DNA.
DR EMBL; AY339580; AAP91361.1; -; Genomic_DNA.
DR EMBL; AY339581; AAP91374.1; -; Genomic_DNA.
DR EMBL; AY339582; AAP91387.1; -; Genomic_DNA.
DR EMBL; AY339583; AAP91400.1; -; Genomic_DNA.
DR EMBL; AY339584; AAP91413.1; -; Genomic_DNA.
DR EMBL; AY339585; AAP91426.1; -; Genomic_DNA.
DR EMBL; AY339586; AAP91439.1; -; Genomic_DNA.
DR EMBL; AY339587; AAP91452.1; -; Genomic_DNA.
DR EMBL; AY339588; AAP91465.1; -; Genomic_DNA.
DR EMBL; AY339589; AAP91478.1; -; Genomic_DNA.
DR EMBL; AY339590; AAP91491.1; -; Genomic_DNA.
DR EMBL; AY339591; AAP91504.1; -; Genomic_DNA.
DR EMBL; AY339592; AAP91517.1; -; Genomic_DNA.
DR EMBL; AY339593; AAP91530.1; -; Genomic_DNA.
DR EMBL; AF346964; AAK17231.1; -; Genomic_DNA.
DR EMBL; AF346965; AAK17244.1; -; Genomic_DNA.
DR EMBL; AF346966; AAK17257.1; -; Genomic_DNA.
DR EMBL; AF346967; AAK17270.1; -; Genomic_DNA.
DR EMBL; AF346971; AAK17322.1; -; Genomic_DNA.
DR EMBL; AF346972; AAK17335.1; -; Genomic_DNA.
DR EMBL; AF346973; AAK17348.1; -; Genomic_DNA.
DR EMBL; AF346974; AAK17361.1; -; Genomic_DNA.
DR EMBL; AF346975; AAK17374.1; -; Genomic_DNA.
DR EMBL; AF346976; AAK17387.1; -; Genomic_DNA.
DR EMBL; AF346977; AAK17400.1; -; Genomic_DNA.
DR EMBL; AF346978; AAK17413.1; -; Genomic_DNA.
DR EMBL; AF346981; AAK17452.1; -; Genomic_DNA.
DR EMBL; AF346982; AAK17465.1; -; Genomic_DNA.
DR EMBL; AF346983; AAK17478.1; -; Genomic_DNA.
DR EMBL; AF346984; AAK17491.1; -; Genomic_DNA.
DR EMBL; AF346985; AAK17504.1; -; Genomic_DNA.
DR EMBL; AF346988; AAK17543.1; -; Genomic_DNA.
DR EMBL; AF346989; AAK17556.1; -; Genomic_DNA.
DR EMBL; AF346990; AAK17569.1; -; Genomic_DNA.
DR EMBL; AF346993; AAK17608.1; -; Genomic_DNA.
DR EMBL; AF346994; AAK17621.1; -; Genomic_DNA.
DR EMBL; AF346995; AAK17634.1; -; Genomic_DNA.
DR EMBL; AF346998; AAK17673.1; -; Genomic_DNA.
DR EMBL; AF346999; AAK17686.1; -; Genomic_DNA.
DR EMBL; AF347000; AAK17699.1; -; Genomic_DNA.
DR EMBL; AF347001; AAK17712.1; -; Genomic_DNA.
DR EMBL; AF347002; AAK17725.1; -; Genomic_DNA.
DR EMBL; AF347003; AAK17738.1; -; Genomic_DNA.
DR EMBL; AF347004; AAK17751.1; -; Genomic_DNA.
DR EMBL; AF347005; AAK17764.1; -; Genomic_DNA.
DR EMBL; AF347006; AAK17777.1; -; Genomic_DNA.
DR EMBL; AF347007; AAK17790.1; -; Genomic_DNA.
DR EMBL; AF347008; AAK17803.1; -; Genomic_DNA.
DR EMBL; AF347009; AAK17816.1; -; Genomic_DNA.
DR EMBL; AF347010; AAK17829.1; -; Genomic_DNA.
DR EMBL; AF347014; AAK17881.1; -; Genomic_DNA.
DR EMBL; AF347015; AAK17894.1; -; Genomic_DNA.
DR EMBL; AY289052; AAP47904.1; -; Genomic_DNA.
DR EMBL; AY289053; AAP47917.1; -; Genomic_DNA.
DR EMBL; AY289056; AAP47956.1; -; Genomic_DNA.
DR EMBL; AY289057; AAP47969.1; -; Genomic_DNA.
DR EMBL; AY289058; AAP47982.1; -; Genomic_DNA.
DR EMBL; AY289059; AAP47995.1; -; Genomic_DNA.
DR EMBL; AY289060; AAP48008.1; -; Genomic_DNA.
DR EMBL; AY289062; AAP48034.1; -; Genomic_DNA.
DR EMBL; AY289063; AAP48047.1; -; Genomic_DNA.
DR EMBL; AY289064; AAP48060.1; -; Genomic_DNA.
DR EMBL; AY289065; AAP48073.1; -; Genomic_DNA.
DR EMBL; AY289066; AAP48086.1; -; Genomic_DNA.
DR EMBL; AY289067; AAP48099.1; -; Genomic_DNA.
DR EMBL; AY289068; AAP48112.1; -; Genomic_DNA.
DR EMBL; AY289069; AAP48125.1; -; Genomic_DNA.
DR EMBL; AY289070; AAP48138.1; -; Genomic_DNA.
DR EMBL; AY289071; AAP48151.1; -; Genomic_DNA.
DR EMBL; AY289072; AAP48164.1; -; Genomic_DNA.
DR EMBL; AY289073; AAP48177.1; -; Genomic_DNA.
DR EMBL; AY289074; AAP48190.1; -; Genomic_DNA.
DR EMBL; AY289075; AAP48203.1; -; Genomic_DNA.
DR EMBL; AY289076; AAP48216.1; -; Genomic_DNA.
DR EMBL; AY289077; AAP48229.1; -; Genomic_DNA.
DR EMBL; AY289078; AAP48242.1; -; Genomic_DNA.
DR EMBL; AY289079; AAP48255.1; -; Genomic_DNA.
DR EMBL; AY289080; AAP48268.1; -; Genomic_DNA.
DR EMBL; AY289081; AAP48281.1; -; Genomic_DNA.
DR EMBL; AY289082; AAP48294.1; -; Genomic_DNA.
DR EMBL; AY289083; AAP48307.1; -; Genomic_DNA.
DR EMBL; AY289084; AAP48320.1; -; Genomic_DNA.
DR EMBL; AY289085; AAP48333.1; -; Genomic_DNA.
DR EMBL; AY289086; AAP48346.1; -; Genomic_DNA.
DR EMBL; AY289088; AAP48372.1; -; Genomic_DNA.
DR EMBL; AY289089; AAP48385.1; -; Genomic_DNA.
DR EMBL; AY289090; AAP48398.1; -; Genomic_DNA.
DR EMBL; AY289091; AAP48411.1; -; Genomic_DNA.
DR EMBL; AY289092; AAP48423.1; -; Genomic_DNA.
DR EMBL; AY289093; AAP48436.1; -; Genomic_DNA.
DR EMBL; AY289094; AAP48449.1; -; Genomic_DNA.
DR EMBL; AY289095; AAP48462.1; -; Genomic_DNA.
DR EMBL; AY289096; AAP48475.1; -; Genomic_DNA.
DR EMBL; AY289097; AAP48488.1; -; Genomic_DNA.
DR EMBL; AY289098; AAP48501.1; -; Genomic_DNA.
DR EMBL; AY289099; AAP48514.1; -; Genomic_DNA.
DR EMBL; AY289100; AAP48527.1; -; Genomic_DNA.
DR EMBL; AY289101; AAP48540.1; -; Genomic_DNA.
DR EMBL; AY289102; AAP48553.1; -; Genomic_DNA.
DR EMBL; AY495090; AAR92507.1; -; Genomic_DNA.
DR EMBL; AY495091; AAR92520.1; -; Genomic_DNA.
DR EMBL; AY495092; AAR92533.1; -; Genomic_DNA.
DR EMBL; AY495093; AAR92546.1; -; Genomic_DNA.
DR EMBL; AY495094; AAR92559.1; -; Genomic_DNA.
DR EMBL; AY495096; AAR92585.1; -; Genomic_DNA.
DR EMBL; AY495097; AAR92598.1; -; Genomic_DNA.
DR EMBL; AY495098; AAR92611.1; -; Genomic_DNA.
DR EMBL; AY495099; AAR92624.1; -; Genomic_DNA.
DR EMBL; AY495100; AAR92637.1; -; Genomic_DNA.
DR EMBL; AY495101; AAR92650.1; -; Genomic_DNA.
DR EMBL; AY495102; AAR92663.1; -; Genomic_DNA.
DR EMBL; AY495103; AAR92676.1; -; Genomic_DNA.
DR EMBL; AY495104; AAR92689.1; -; Genomic_DNA.
DR EMBL; AY495105; AAR92702.1; -; Genomic_DNA.
DR EMBL; AY495106; AAR92715.1; -; Genomic_DNA.
DR EMBL; AY495107; AAR92728.1; -; Genomic_DNA.
DR EMBL; AY495109; AAR92754.1; -; Genomic_DNA.
DR EMBL; AY495110; AAR92767.1; -; Genomic_DNA.
DR EMBL; AY495112; AAR92793.1; -; Genomic_DNA.
DR EMBL; AY495113; AAR92806.1; -; Genomic_DNA.
DR EMBL; AY495114; AAR92819.1; -; Genomic_DNA.
DR EMBL; AY495115; AAR92832.1; -; Genomic_DNA.
DR EMBL; AY495116; AAR92845.1; -; Genomic_DNA.
DR EMBL; AY495117; AAR92858.1; -; Genomic_DNA.
DR EMBL; AY495118; AAR92871.1; -; Genomic_DNA.
DR EMBL; AY495119; AAR92884.1; -; Genomic_DNA.
DR EMBL; AY495120; AAR92897.1; -; Genomic_DNA.
DR EMBL; AY495121; AAR92910.1; -; Genomic_DNA.
DR EMBL; AY495122; AAR92923.1; -; Genomic_DNA.
DR EMBL; AY495124; AAR92949.1; -; Genomic_DNA.
DR EMBL; AY495125; AAR92962.1; -; Genomic_DNA.
DR EMBL; AY495126; AAR92975.1; -; Genomic_DNA.
DR EMBL; AY495128; AAR93001.1; -; Genomic_DNA.
DR EMBL; AY495129; AAR93014.1; -; Genomic_DNA.
DR EMBL; AY495130; AAR93027.1; -; Genomic_DNA.
DR EMBL; AY495131; AAR93040.1; -; Genomic_DNA.
DR EMBL; AY495132; AAR93053.1; -; Genomic_DNA.
DR EMBL; AY495133; AAR93066.1; -; Genomic_DNA.
DR EMBL; AY495134; AAR93079.1; -; Genomic_DNA.
DR EMBL; AY495135; AAR93092.1; -; Genomic_DNA.
DR EMBL; AY495136; AAR93105.1; -; Genomic_DNA.
DR EMBL; AY495137; AAR93118.1; -; Genomic_DNA.
DR EMBL; AY495138; AAR93131.1; -; Genomic_DNA.
DR EMBL; AY495139; AAR93144.1; -; Genomic_DNA.
DR EMBL; AY495140; AAR93157.1; -; Genomic_DNA.
DR EMBL; AY495141; AAR93170.1; -; Genomic_DNA.
DR EMBL; AY495142; AAR93183.1; -; Genomic_DNA.
DR EMBL; AY495143; AAR93196.1; -; Genomic_DNA.
DR EMBL; AY495144; AAR93209.1; -; Genomic_DNA.
DR EMBL; AY495145; AAR93222.1; -; Genomic_DNA.
DR EMBL; AY495146; AAR93235.1; -; Genomic_DNA.
DR EMBL; AY495147; AAR93248.1; -; Genomic_DNA.
DR EMBL; AY495148; AAR93261.1; -; Genomic_DNA.
DR EMBL; AY495149; AAR93274.1; -; Genomic_DNA.
DR EMBL; AY495150; AAR93287.1; -; Genomic_DNA.
DR EMBL; AY495151; AAR93300.1; -; Genomic_DNA.
DR EMBL; AY495152; AAR93313.1; -; Genomic_DNA.
DR EMBL; AY495153; AAR93326.1; -; Genomic_DNA.
DR EMBL; AY495154; AAR93339.1; -; Genomic_DNA.
DR EMBL; AY495155; AAR93352.1; -; Genomic_DNA.
DR EMBL; AY495156; AAR93365.1; -; Genomic_DNA.
DR EMBL; AY495157; AAR93378.1; -; Genomic_DNA.
DR EMBL; AY495158; AAR93391.1; -; Genomic_DNA.
DR EMBL; AY495159; AAR93404.1; -; Genomic_DNA.
DR EMBL; AY495160; AAR93417.1; -; Genomic_DNA.
DR EMBL; AY495161; AAR93430.1; -; Genomic_DNA.
DR EMBL; AY495162; AAR93443.1; -; Genomic_DNA.
DR EMBL; AY495163; AAR93456.1; -; Genomic_DNA.
DR EMBL; AY495164; AAR93469.1; -; Genomic_DNA.
DR EMBL; AY495165; AAR93482.1; -; Genomic_DNA.
DR EMBL; AY495166; AAR93495.1; -; Genomic_DNA.
DR EMBL; AY495167; AAR93508.1; -; Genomic_DNA.
DR EMBL; AY495168; AAR93521.1; -; Genomic_DNA.
DR EMBL; AY495169; AAR93534.1; -; Genomic_DNA.
DR EMBL; AY495170; AAR93547.1; -; Genomic_DNA.
DR EMBL; AY495171; AAR93560.1; -; Genomic_DNA.
DR EMBL; AY495172; AAR93573.1; -; Genomic_DNA.
DR EMBL; AY495173; AAR93586.1; -; Genomic_DNA.
DR EMBL; AY495174; AAR93599.1; -; Genomic_DNA.
DR EMBL; AY495175; AAR93612.1; -; Genomic_DNA.
DR EMBL; AY495176; AAR93625.1; -; Genomic_DNA.
DR EMBL; AY495177; AAR93638.1; -; Genomic_DNA.
DR EMBL; AY495180; AAR93677.1; -; Genomic_DNA.
DR EMBL; AY495185; AAR93742.1; -; Genomic_DNA.
DR EMBL; AY495187; AAR93768.1; -; Genomic_DNA.
DR EMBL; AY495188; AAR93781.1; -; Genomic_DNA.
DR EMBL; AY495189; AAR93794.1; -; Genomic_DNA.
DR EMBL; AY495190; AAR93807.1; -; Genomic_DNA.
DR EMBL; AY495191; AAR93820.1; -; Genomic_DNA.
DR EMBL; AY495192; AAR93833.1; -; Genomic_DNA.
DR EMBL; AY495193; AAR93846.1; -; Genomic_DNA.
DR EMBL; AY495194; AAR93859.1; -; Genomic_DNA.
DR EMBL; AY495195; AAR93872.1; -; Genomic_DNA.
DR EMBL; AY495196; AAR93885.1; -; Genomic_DNA.
DR EMBL; AY495197; AAR93898.1; -; Genomic_DNA.
DR EMBL; AY495198; AAR93911.1; -; Genomic_DNA.
DR EMBL; AY495199; AAR93924.1; -; Genomic_DNA.
DR EMBL; AY495200; AAR93937.1; -; Genomic_DNA.
DR EMBL; AY495201; AAR93950.1; -; Genomic_DNA.
DR EMBL; AY495202; AAR93963.1; -; Genomic_DNA.
DR EMBL; AY495203; AAR93976.1; -; Genomic_DNA.
DR EMBL; AY495204; AAR93989.1; -; Genomic_DNA.
DR EMBL; AY495205; AAR94002.1; -; Genomic_DNA.
DR EMBL; AY495206; AAR94015.1; -; Genomic_DNA.
DR EMBL; AY495207; AAR94028.1; -; Genomic_DNA.
DR EMBL; AY495208; AAR94041.1; -; Genomic_DNA.
DR EMBL; AY495210; AAR94067.1; -; Genomic_DNA.
DR EMBL; AY495211; AAR94080.1; -; Genomic_DNA.
DR EMBL; AY495212; AAR94093.1; -; Genomic_DNA.
DR EMBL; AY495213; AAR94106.1; -; Genomic_DNA.
DR EMBL; AY495214; AAR94119.1; -; Genomic_DNA.
DR EMBL; AY495216; AAR94145.1; -; Genomic_DNA.
DR EMBL; AY495217; AAR94158.1; -; Genomic_DNA.
DR EMBL; AY495218; AAR94171.1; -; Genomic_DNA.
DR EMBL; AY495219; AAR94184.1; -; Genomic_DNA.
DR EMBL; AY495220; AAR94197.1; -; Genomic_DNA.
DR EMBL; AY495221; AAR94210.1; -; Genomic_DNA.
DR EMBL; AY495222; AAR94223.1; -; Genomic_DNA.
DR EMBL; AY495223; AAR94236.1; -; Genomic_DNA.
DR EMBL; AY495224; AAR94249.1; -; Genomic_DNA.
DR EMBL; AY495225; AAR94262.1; -; Genomic_DNA.
DR EMBL; AY495226; AAR94275.1; -; Genomic_DNA.
DR EMBL; AY495227; AAR94288.1; -; Genomic_DNA.
DR EMBL; AY495228; AAR94301.1; -; Genomic_DNA.
DR EMBL; AY495229; AAR94314.1; -; Genomic_DNA.
DR EMBL; AY495230; AAR94327.1; -; Genomic_DNA.
DR EMBL; AY495231; AAR94340.1; -; Genomic_DNA.
DR EMBL; AY495232; AAR94353.1; -; Genomic_DNA.
DR EMBL; AY495233; AAR94366.1; -; Genomic_DNA.
DR EMBL; AY495234; AAR94379.1; -; Genomic_DNA.
DR EMBL; AY495235; AAR94392.1; -; Genomic_DNA.
DR EMBL; AY495236; AAR94405.1; -; Genomic_DNA.
DR EMBL; AY495237; AAR94418.1; -; Genomic_DNA.
DR EMBL; AY495238; AAR94431.1; -; Genomic_DNA.
DR EMBL; AY495239; AAR94444.1; -; Genomic_DNA.
DR EMBL; AY495240; AAR94457.1; -; Genomic_DNA.
DR EMBL; AY495241; AAR94470.1; -; Genomic_DNA.
DR EMBL; AY495242; AAR94483.1; -; Genomic_DNA.
DR EMBL; AY495243; AAR94496.1; -; Genomic_DNA.
DR EMBL; AY495244; AAR94509.1; -; Genomic_DNA.
DR EMBL; AY495245; AAR94522.1; -; Genomic_DNA.
DR EMBL; AY495246; AAR94535.1; -; Genomic_DNA.
DR EMBL; AY495247; AAR94548.1; -; Genomic_DNA.
DR EMBL; AY495248; AAR94561.1; -; Genomic_DNA.
DR EMBL; AY495249; AAR94574.1; -; Genomic_DNA.
DR EMBL; AY495250; AAR94587.1; -; Genomic_DNA.
DR EMBL; AY495251; AAR94600.1; -; Genomic_DNA.
DR EMBL; AY495252; AAR94613.1; -; Genomic_DNA.
DR EMBL; AY495253; AAR94626.1; -; Genomic_DNA.
DR EMBL; AY495254; AAR94639.1; -; Genomic_DNA.
DR EMBL; AY495255; AAR94652.1; -; Genomic_DNA.
DR EMBL; AY495256; AAR94665.1; -; Genomic_DNA.
DR EMBL; AY495257; AAR94678.1; -; Genomic_DNA.
DR EMBL; AY495258; AAR94691.1; -; Genomic_DNA.
DR EMBL; AY495259; AAR94704.1; -; Genomic_DNA.
DR EMBL; AY495261; AAR94730.1; -; Genomic_DNA.
DR EMBL; AY495262; AAR94743.1; -; Genomic_DNA.
DR EMBL; AY495263; AAR94756.1; -; Genomic_DNA.
DR EMBL; AY495264; AAR94769.1; -; Genomic_DNA.
DR EMBL; AY495266; AAR94795.1; -; Genomic_DNA.
DR EMBL; AY495267; AAR94808.1; -; Genomic_DNA.
DR EMBL; AY495268; AAR94821.1; -; Genomic_DNA.
DR EMBL; AY495269; AAR94834.1; -; Genomic_DNA.
DR EMBL; AY495270; AAR94847.1; -; Genomic_DNA.
DR EMBL; AY495271; AAR94860.1; -; Genomic_DNA.
DR EMBL; AY495272; AAR94873.1; -; Genomic_DNA.
DR EMBL; AY495273; AAR94886.1; -; Genomic_DNA.
DR EMBL; AY495274; AAR94899.1; -; Genomic_DNA.
DR EMBL; AY495275; AAR94912.1; -; Genomic_DNA.
DR EMBL; AY495276; AAR94925.1; -; Genomic_DNA.
DR EMBL; AY495277; AAR94938.1; -; Genomic_DNA.
DR EMBL; AY495278; AAR94951.1; -; Genomic_DNA.
DR EMBL; AY495279; AAR94964.1; -; Genomic_DNA.
DR EMBL; AY495280; AAR94977.1; -; Genomic_DNA.
DR EMBL; AY495281; AAR94990.1; -; Genomic_DNA.
DR EMBL; AY495282; AAR95003.1; -; Genomic_DNA.
DR EMBL; AY495283; AAR95016.1; -; Genomic_DNA.
DR EMBL; AY495284; AAR95029.1; -; Genomic_DNA.
DR EMBL; AY495285; AAR95042.1; -; Genomic_DNA.
DR EMBL; AY495286; AAR95055.1; -; Genomic_DNA.
DR EMBL; AY495287; AAR95068.1; -; Genomic_DNA.
DR EMBL; AY495288; AAR95081.1; -; Genomic_DNA.
DR EMBL; AY495289; AAR95094.1; -; Genomic_DNA.
DR EMBL; AY495290; AAR95107.1; -; Genomic_DNA.
DR EMBL; AY495291; AAR95120.1; -; Genomic_DNA.
DR EMBL; AY495292; AAR95133.1; -; Genomic_DNA.
DR EMBL; AY495293; AAR95146.1; -; Genomic_DNA.
DR EMBL; AY495294; AAR95159.1; -; Genomic_DNA.
DR EMBL; AY495295; AAR95172.1; -; Genomic_DNA.
DR EMBL; AY495296; AAR95185.1; -; Genomic_DNA.
DR EMBL; AY495297; AAR95198.1; -; Genomic_DNA.
DR EMBL; AY495298; AAR95211.1; -; Genomic_DNA.
DR EMBL; AY495299; AAR95224.1; -; Genomic_DNA.
DR EMBL; AY495300; AAR95237.1; -; Genomic_DNA.
DR EMBL; AY495301; AAR95250.1; -; Genomic_DNA.
DR EMBL; AY495302; AAR95263.1; -; Genomic_DNA.
DR EMBL; AY495303; AAR95276.1; -; Genomic_DNA.
DR EMBL; AY495304; AAR95289.1; -; Genomic_DNA.
DR EMBL; AY495305; AAR95302.1; -; Genomic_DNA.
DR EMBL; AY495306; AAR95315.1; -; Genomic_DNA.
DR EMBL; AY495307; AAR95328.1; -; Genomic_DNA.
DR EMBL; AY495308; AAR95341.1; -; Genomic_DNA.
DR EMBL; AY495310; AAR95367.1; -; Genomic_DNA.
DR EMBL; AY495311; AAR95380.1; -; Genomic_DNA.
DR EMBL; AY495312; AAR95393.1; -; Genomic_DNA.
DR EMBL; AY495313; AAR95406.1; -; Genomic_DNA.
DR EMBL; AY495314; AAR95419.1; -; Genomic_DNA.
DR EMBL; AY495315; AAR95432.1; -; Genomic_DNA.
DR EMBL; AY495316; AAR95445.1; -; Genomic_DNA.
DR EMBL; AY495317; AAR95458.1; -; Genomic_DNA.
DR EMBL; AY495318; AAR95471.1; -; Genomic_DNA.
DR EMBL; AY495319; AAR95484.1; -; Genomic_DNA.
DR EMBL; AY495320; AAR95497.1; -; Genomic_DNA.
DR EMBL; AY495321; AAR95510.1; -; Genomic_DNA.
DR EMBL; AY495322; AAR95523.1; -; Genomic_DNA.
DR EMBL; AY495323; AAR95536.1; -; Genomic_DNA.
DR EMBL; AY495324; AAR95549.1; -; Genomic_DNA.
DR EMBL; AY495325; AAR95562.1; -; Genomic_DNA.
DR EMBL; AY495326; AAR95575.1; -; Genomic_DNA.
DR EMBL; AY495327; AAR95588.1; -; Genomic_DNA.
DR EMBL; AY495328; AAR95601.1; -; Genomic_DNA.
DR EMBL; AY495329; AAR95614.1; -; Genomic_DNA.
DR EMBL; AY495330; AAR95627.1; -; Genomic_DNA.
DR PIR; A00455; DEHUN6.
DR RefSeq; YP_003024037.1; NC_012920.1.
DR PDB; 5XTC; EM; 3.70 A; m=1-174.
DR PDB; 5XTD; EM; 3.70 A; m=1-174.
DR PDBsum; 5XTC; -.
DR PDBsum; 5XTD; -.
DR AlphaFoldDB; P03923; -.
DR SMR; P03923; -.
DR BioGRID; 110637; 7.
DR ComplexPortal; CPX-577; Mitochondrial respiratory chain complex I.
DR CORUM; P03923; -.
DR IntAct; P03923; 5.
DR MINT; P03923; -.
DR STRING; 9606.ENSP00000354665; -.
DR BindingDB; P03923; -.
DR ChEMBL; CHEMBL2363065; -.
DR DrugBank; DB00157; NADH.
DR DrugCentral; P03923; -.
DR SwissPalm; P03923; -.
DR BioMuta; MT-ND6; -.
DR DMDM; 6648060; -.
DR EPD; P03923; -.
DR jPOST; P03923; -.
DR MassIVE; P03923; -.
DR PaxDb; 9606-ENSP00000354665; -.
DR PeptideAtlas; P03923; -.
DR ProteomicsDB; 51617; -.
DR TopDownProteomics; P03923; -.
DR Antibodypedia; 35364; 141 antibodies from 20 providers.
DR DNASU; 4541; -.
DR Ensembl; ENST00000361681.2; ENSP00000354665.2; ENSG00000198695.2.
DR GeneID; 4541; -.
DR KEGG; hsa:4541; -.
DR AGR; HGNC:7462; -.
DR CTD; 4541; -.
DR DisGeNET; 4541; -.
DR GeneCards; MT-ND6; -.
DR GeneReviews; MT-ND6; -.
DR HGNC; HGNC:7462; MT-ND6.
DR HPA; ENSG00000198695; Tissue enhanced (heart muscle, skeletal muscle).
DR MalaCards; MT-ND6; -.
DR MIM; 256000; phenotype.
DR MIM; 500001; phenotype.
DR MIM; 516006; gene.
DR MIM; 535000; phenotype.
DR MIM; 540000; phenotype.
DR neXtProt; NX_P03923; -.
DR OpenTargets; ENSG00000198695; -.
DR Orphanet; 104; Leber hereditary optic neuropathy.
DR Orphanet; 99718; Leber plus disease.
DR Orphanet; 550; MELAS.
DR Orphanet; 255210; Mitochondrial DNA-associated Leigh syndrome.
DR PharmGKB; PA31266; -.
DR VEuPathDB; HostDB:ENSG00000198695; -.
DR eggNOG; ENOG502S2Q2; Eukaryota.
DR GeneTree; ENSGT00390000003988; -.
DR HOGENOM; CLU_129718_0_0_1; -.
DR InParanoid; P03923; -.
DR OMA; WVIYDTG; -.
DR PhylomeDB; P03923; -.
DR TreeFam; TF343324; -.
DR BioCyc; MetaCyc:HS00036-MONOMER; -.
DR PathwayCommons; P03923; -.
DR Reactome; R-HSA-611105; Respiratory electron transport.
DR Reactome; R-HSA-6799198; Complex I biogenesis.
DR SignaLink; P03923; -.
DR SIGNOR; P03923; -.
DR BioGRID-ORCS; 4541; 0 hits in 3 CRISPR screens.
DR ChiTaRS; MT-ND6; human.
DR GeneWiki; MT-ND6; -.
DR GenomeRNAi; 4541; -.
DR Pharos; P03923; Tclin.
DR PRO; PR:P03923; -.
DR Proteomes; UP000005640; Mitochondrion.
DR RNAct; P03923; Protein.
DR Bgee; ENSG00000198695; Expressed in mucosa of stomach and 98 other cell types or tissues.
DR ExpressionAtlas; P03923; baseline and differential.
DR Genevisible; P03923; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:ComplexPortal.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IPI:ComplexPortal.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IMP:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; NAS:ComplexPortal.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IMP:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
DR GO; GO:0042776; P:proton motive force-driven mitochondrial ATP synthesis; NAS:ComplexPortal.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR PANTHER; PTHR11435; NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6; 1.
DR PANTHER; PTHR11435:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disease variant; Dystonia; Electron transport;
KW Leber hereditary optic neuropathy; Leigh syndrome; MELAS syndrome;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; NAD;
KW Primary mitochondrial disease; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..174
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118291"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 26
FT /note="I -> M (in LDYT; decrease in enzyme activity;
FT dbSNP:rs387906424)"
FT /evidence="ECO:0000269|PubMed:8644732"
FT /id="VAR_008394"
FT VARIANT 31
FT /note="V -> A (in dbSNP:rs41354845)"
FT /evidence="ECO:0000269|PubMed:11133798"
FT /id="VAR_014393"
FT VARIANT 33
FT /note="I -> V (in dbSNP:rs386829219)"
FT /evidence="ECO:0000269|PubMed:11133798"
FT /id="VAR_014394"
FT VARIANT 36
FT /note="G -> S (in LHON; dbSNP:rs397515506)"
FT /evidence="ECO:0000269|PubMed:10447650"
FT /id="VAR_008395"
FT VARIANT 58
FT /note="I -> V (in dbSNP:rs201327354)"
FT /evidence="ECO:0000269|PubMed:2043137"
FT /id="VAR_014395"
FT VARIANT 59
FT /note="Y -> C (in LHON; dbSNP:rs869025186)"
FT /evidence="ECO:0000269|PubMed:8854108"
FT /id="VAR_008396"
FT VARIANT 60
FT /note="L -> S (in LHON; dbSNP:rs199476106)"
FT /evidence="ECO:0000269|PubMed:11133798"
FT /id="VAR_014396"
FT VARIANT 63
FT /note="M -> V (in LS; decrease in enzyme activity and
FT impaired assembly of complex I; dbSNP:rs199476109)"
FT /evidence="ECO:0000269|PubMed:14595656"
FT /id="VAR_064568"
FT VARIANT 64
FT /note="M -> I (in LHON; dbSNP:rs199476108)"
FT /id="VAR_008512"
FT VARIANT 64
FT /note="M -> V (in LHON; low severity; up to 50% of vision
FT recovery; results in decreased complex I activity;
FT dbSNP:rs199476104)"
FT /evidence="ECO:0000269|PubMed:1417830,
FT ECO:0000269|PubMed:35567411, ECO:0000269|PubMed:9452107"
FT /id="VAR_004763"
FT VARIANT 72
FT /note="A -> V (in LDYT; most severe mutation with no vision
FT recovery; dbSNP:rs199476105)"
FT /evidence="ECO:0000269|PubMed:8016139"
FT /id="VAR_004764"
FT VARIANT 74
FT /note="A -> V (in MELAS; dbSNP:rs199476107)"
FT /evidence="ECO:0000269|PubMed:11781695"
FT /id="VAR_014397"
FT VARIANT 165
FT /note="Y -> C (in dbSNP:rs200933339)"
FT /evidence="ECO:0000269|PubMed:1757091"
FT /id="VAR_008604"
FT CONFLICT 102
FT /note="L -> F (in Ref. 1; CAA24037)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="L -> F (in Ref. 1; CAA24037)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="T -> P (in Ref. 1; CAA24037)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 174 AA; 18622 MW; E50CD9F3FAFC600D CRC64;
MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY MGLMVFLIYL
GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV GLVLWVKEYD GVVVVVNFNS
VGSWMIYEGE GSGLIREDPI GAGALYDYGR WLVVVTGWTL FVGVYIVIEI ARGN
//
