ID NU6M_PONAB Reviewed; 174 AA.
AC P92700;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6;
DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03923};
DE AltName: Full=NADH dehydrogenase subunit 6;
GN Name=MT-ND6; Synonyms=MTND6, NADH6, ND6;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8875856; DOI=10.1007/bf02337514;
RA Xu X., Arnason U.;
RT "The mitochondrial DNA molecule of Sumatran orangutan and a molecular
RT proposal for two (Bornean and Sumatran) species of orangutan.";
RL J. Mol. Evol. 43:431-437(1996).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000250|UniProtKB:P03923}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000250|UniProtKB:P03923};
CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC I) which is composed of 45 different subunits.
CC {ECO:0000250|UniProtKB:P03924}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P03924}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. {ECO:0000305}.
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DR EMBL; X97707; CAA66294.1; -; Genomic_DNA.
DR RefSeq; NP_007846.1; NC_002083.1.
DR AlphaFoldDB; P92700; -.
DR SMR; P92700; -.
DR STRING; 9601.ENSPPYP00000023450; -.
DR Ensembl; ENSPPYT00000024451.1; ENSPPYP00000023450.1; ENSPPYG00000020972.1.
DR GeneID; 808476; -.
DR KEGG; pon:808476; -.
DR CTD; 4541; -.
DR eggNOG; ENOG502S2Q2; Eukaryota.
DR GeneTree; ENSGT00390000003988; -.
DR HOGENOM; CLU_129718_0_0_1; -.
DR InParanoid; P92700; -.
DR OMA; WVIYDTG; -.
DR OrthoDB; 4268134at2759; -.
DR TreeFam; TF343324; -.
DR Proteomes; UP000001595; Mitochondrion.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR PANTHER; PTHR11435; NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6; 1.
DR PANTHER; PTHR11435:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW NAD; Reference proteome; Respiratory chain; Translocase; Transmembrane;
KW Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..174
FT /note="NADH-ubiquinone oxidoreductase chain 6"
FT /id="PRO_0000118319"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 174 AA; 18562 MW; A3BE85628CB18FA8 CRC64;
MTYALFLLSV ILVMGFVGFS SKPSPIYGGL VLIISGAVGC AVILNCGGGY MGLMVFLIYL
GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLVMEV GLVLWVKEYD GVVVVVNFNS
VGSWMIYEGE GSGLIREDPI GAGALYDYGR WLVVVTGWTL FVGVYVVIEI ARGN
//
