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Database: UniProt
Entry: O00634
LinkDB: O00634
Original site: O00634 
ID   NET3_HUMAN              Reviewed;         580 AA.
AC   O00634;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   13-FEB-2019, entry version 151.
DE   RecName: Full=Netrin-3;
DE   AltName: Full=Netrin-2-like protein;
DE   Flags: Precursor;
GN   Name=NTN3; Synonyms=NTN2L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8828041; DOI=10.1101/gr.6.6.525;
RA   Burn T.C., Connors T.D., Van Raay T.J., Dackowski W.R.,
RA   Millholland J.M., Klinger K.W., Landes G.M.;
RT   "Generation of a transcriptional map for a 700-kb region surrounding
RT   the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis
RT   type 2 (TSC2) disease genes on human chromosome 16p3.3.";
RL   Genome Res. 6:525-537(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=9143507; DOI=10.1006/geno.1997.4659;
RA   Van Raay T.J., Foskett S.M., Connors T.D., Klinger K.W., Landes G.M.,
RA   Burn T.C.;
RT   "The NTN2L gene encoding a novel human netrin maps to the autosomal
RT   dominant polycystic kidney disease region on chromosome 16p13.3.";
RL   Genomics 41:279-282(1997).
CC   -!- FUNCTION: Netrins control guidance of CNS commissural axons and
CC       peripheral motor axons. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8NBI3:DRAXIN; NbExp=2; IntAct=EBI-10831998, EBI-10827752;
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Spinal cord. {ECO:0000269|PubMed:9143507}.
DR   EMBL; U86759; AAC51247.1; -; mRNA.
DR   EMBL; U86758; AAC51246.1; -; Genomic_DNA.
DR   CCDS; CCDS10469.1; -.
DR   RefSeq; NP_006172.1; NM_006181.2.
DR   UniGene; Hs.158336; -.
DR   ProteinModelPortal; O00634; -.
DR   SMR; O00634; -.
DR   IntAct; O00634; 1.
DR   STRING; 9606.ENSP00000293973; -.
DR   GlyConnect; 1543; -.
DR   iPTMnet; O00634; -.
DR   PhosphoSitePlus; O00634; -.
DR   BioMuta; NTN3; -.
DR   PaxDb; O00634; -.
DR   PeptideAtlas; O00634; -.
DR   PRIDE; O00634; -.
DR   ProteomicsDB; 48004; -.
DR   Ensembl; ENST00000293973; ENSP00000293973; ENSG00000162068.
DR   GeneID; 4917; -.
DR   KEGG; hsa:4917; -.
DR   UCSC; uc002cqj.3; human.
DR   CTD; 4917; -.
DR   EuPathDB; HostDB:ENSG00000162068.1; -.
DR   GeneCards; NTN3; -.
DR   HGNC; HGNC:8030; NTN3.
DR   HPA; HPA050817; -.
DR   MIM; 602349; gene.
DR   neXtProt; NX_O00634; -.
DR   OpenTargets; ENSG00000162068; -.
DR   PharmGKB; PA164724231; -.
DR   eggNOG; KOG3512; Eukaryota.
DR   eggNOG; ENOG410XS7U; LUCA.
DR   GeneTree; ENSGT00940000153882; -.
DR   HOGENOM; HOG000286017; -.
DR   HOVERGEN; HBG006464; -.
DR   InParanoid; O00634; -.
DR   KO; K06844; -.
DR   OMA; CVKTPVP; -.
DR   OrthoDB; 858946at2759; -.
DR   PhylomeDB; O00634; -.
DR   TreeFam; TF352481; -.
DR   Reactome; R-HSA-375170; CDO in myogenesis.
DR   GenomeRNAi; 4917; -.
DR   PRO; PR:O00634; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000162068; Expressed in 28 organ(s), highest expression level in heart left ventricle.
DR   Genevisible; O00634; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; NAS:UniProtKB.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF00055; Laminin_N; 1.
DR   Pfam; PF01759; NTR; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF50242; SSF50242; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01248; EGF_LAM_1; 3.
DR   PROSITE; PS50027; EGF_LAM_2; 3.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein;
KW   Laminin EGF-like domain; Polymorphism; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL        1     27       {ECO:0000255}.
FT   CHAIN        28    580       Netrin-3.
FT                                /FTId=PRO_0000017085.
FT   DOMAIN       36    254       Laminin N-terminal. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00466}.
FT   DOMAIN      255    308       Laminin EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00460}.
FT   DOMAIN      311    371       Laminin EGF-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00460}.
FT   DOMAIN      374    421       Laminin EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00460}.
FT   DOMAIN      441    577       NTR. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00295}.
FT   MOTIF       500    502       Cell attachment site; atypical.
FT                                {ECO:0000255}.
FT   CARBOHYD    104    104       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    387    387       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     92    125       {ECO:0000250}.
FT   DISULFID    255    264       {ECO:0000250}.
FT   DISULFID    257    274       {ECO:0000250}.
FT   DISULFID    276    285       {ECO:0000250}.
FT   DISULFID    288    308       {ECO:0000250}.
FT   DISULFID    311    320       {ECO:0000250}.
FT   DISULFID    313    338       {ECO:0000250}.
FT   DISULFID    341    350       {ECO:0000250}.
FT   DISULFID    353    371       {ECO:0000250}.
FT   DISULFID    374    386       {ECO:0000250}.
FT   DISULFID    376    393       {ECO:0000250}.
FT   DISULFID    395    404       {ECO:0000250}.
FT   DISULFID    407    421       {ECO:0000250}.
FT   DISULFID    441    514       {ECO:0000250}.
FT   DISULFID    460    577       {ECO:0000250}.
FT   VARIANT     425    425       P -> S (in dbSNP:rs34818219).
FT                                /FTId=VAR_050086.
SQ   SEQUENCE   580 AA;  61466 MW;  15F99643E74C644C CRC64;
     MPGWPWGLLL TAGTLFAALS PGPPAPADPC HDEGGAPRGC VPGLVNAALG REVLASSTCG
     RPATRACDAS DPRRAHSPAL LTSPGGTASP LCWRSESLPR APLNVTLTVP LGKAFELVFV
     SLRFCSAPPA SVALLKSQDH GRSWAPLGFF SSHCDLDYGR LPAPANGPAG PGPEALCFPA
     PLAQPDGSGL LAFSMQDSSP PGLDLDSSPV LQDWVTATDV RVVLTRPSTA GDPRDMEAVV
     PYSYAATDLQ VGGRCKCNGH ASRCLLDTQG HLICDCRHGT EGPDCGRCKP FYCDRPWQRA
     TARESHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC HYCREGFYRD
     PGRALSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT GLTCNRCAPG FQQSRSPVAP
     CVKTPIPGPT EDSSPVQPQD CDSHCKPARG SYRISLKKFC KKDYAVQVAV GARGEARGAW
     TRFPVAVLAV FRSGEERARR GSSALWVPAG DAACGCPRLL PGRRYLLLGG GPGAAAGGAG
     GRGPGLIAAR GSLVLPWRDA WTRRLRRLQR RERRGRCSAA
//
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