ID O01426_CAEEL Unreviewed; 268 AA.
AC O01426;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 2.
DT 27-MAR-2024, entry version 146.
DE RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588, ECO:0000256|RuleBase:RU365059};
GN ORFNames=B0207.6 {ECO:0000313|EMBL:CCD61318.1,
GN ECO:0000313|WormBase:B0207.6}, CELE_B0207.6
GN {ECO:0000313|EMBL:CCD61318.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD61318.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD61318.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD61318.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181,
CC ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; BX284601; CCD61318.1; -; Genomic_DNA.
DR PIR; A87790; A87790.
DR RefSeq; NP_491713.2; NM_059312.2.
DR AlphaFoldDB; O01426; -.
DR SMR; O01426; -.
DR DIP; DIP-26202N; -.
DR IntAct; O01426; 1.
DR STRING; 6239.B0207.6.1; -.
DR EPD; O01426; -.
DR PaxDb; 6239-B0207-6; -.
DR PeptideAtlas; O01426; -.
DR EnsemblMetazoa; B0207.6.1; B0207.6.1; WBGene00015029.
DR GeneID; 172267; -.
DR KEGG; cel:CELE_B0207.6; -.
DR UCSC; B0207.6; c. elegans.
DR AGR; WB:WBGene00015029; -.
DR WormBase; B0207.6; CE30229; WBGene00015029; -.
DR eggNOG; KOG1533; Eukaryota.
DR GeneTree; ENSGT00950000183172; -.
DR HOGENOM; CLU_037460_0_0_1; -.
DR InParanoid; O01426; -.
DR OMA; ATHNYFL; -.
DR OrthoDB; 168004at2759; -.
DR PhylomeDB; O01426; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00015029; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR CDD; cd17871; GPN2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030231; Gpn2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Proteomics identification {ECO:0007829|EPD:O01426,
KW ECO:0007829|PeptideAtlas:O01426};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
SQ SEQUENCE 268 AA; 29606 MW; EA7C78556E5C56DC CRC64;
MYGVLVIGAP GAGKSTFCAG LTDIFSQTKR PFLTINLDPA NDTMAYAPDV NITEMITVND
VMDRLGLGPN GALKYCIETL GANCNWLLQK IEANHKKYLI IDCPGQLELY KSEGELWKVI
RFLEKSGVRL CALHLADSLY CSDPSKFISV ALSTLATMVT MEMPQVNCLS KADLFSEDGT
YDLEFFSHLP DVNRLLDLLN EVPGLEKYRK LNEAICGVIS DFDLVSFVPL AVENKESMMK
VIQMVDAANG FSLTEQGDIR ELILNSKA
//
