ID O01755_CAEEL Unreviewed; 426 AA.
AC O01755;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 2.
DT 27-MAR-2024, entry version 161.
DE SubName: Full=MHD domain-containing protein {ECO:0000313|EMBL:CCD65442.1};
GN Name=apm-1 {ECO:0000313|EMBL:CCD65442.1,
GN ECO:0000313|WormBase:F55A12.7};
GN ORFNames=CELE_F55A12.7 {ECO:0000313|EMBL:CCD65442.1}, F55A12.7
GN {ECO:0000313|WormBase:F55A12.7};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD65442.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD65442.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD65442.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000256|PIRNR:PIRNR005992}.
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DR EMBL; BX284601; CCD65442.1; -; Genomic_DNA.
DR PIR; T15189; T15189.
DR RefSeq; NP_491572.2; NM_059171.5.
DR AlphaFoldDB; O01755; -.
DR SMR; O01755; -.
DR STRING; 6239.F55A12.7.1; -.
DR EPD; O01755; -.
DR PaxDb; 6239-F55A12-7; -.
DR PeptideAtlas; O01755; -.
DR EnsemblMetazoa; F55A12.7.1; F55A12.7.1; WBGene00000150.
DR GeneID; 172180; -.
DR KEGG; cel:CELE_F55A12.7; -.
DR UCSC; F55A12.7; c. elegans.
DR AGR; WB:WBGene00000150; -.
DR WormBase; F55A12.7; CE30145; WBGene00000150; apm-1.
DR eggNOG; KOG0937; Eukaryota.
DR HOGENOM; CLU_026996_0_0_1; -.
DR InParanoid; O01755; -.
DR OMA; VWSIRSF; -.
DR OrthoDB; 6959at2759; -.
DR PhylomeDB; O01755; -.
DR Reactome; R-CEL-432720; Lysosome Vesicle Biogenesis.
DR Reactome; R-CEL-432722; Golgi Associated Vesicle Biogenesis.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000150; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030136; C:clathrin-coated vesicle; IBA:GO_Central.
DR GO; GO:0035615; F:clathrin adaptor activity; IBA:GO_Central.
DR GO; GO:0045176; P:apical protein localization; IGI:WormBase.
DR GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR CDD; cd09250; AP-1_Mu1_Cterm; 1.
DR CDD; cd14835; AP1_Mu_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR Gene3D; 2.60.40.1170; Mu homology domain, subdomain B; 2.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR018240; Clathrin_mu_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR028565; MHD.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF364; MHD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF005992; Clathrin_mu; 1.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
DR PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR PROSITE; PS51072; MHD; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005992};
KW Proteomics identification {ECO:0007829|EPD:O01755,
KW ECO:0007829|PeptideAtlas:O01755};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005992}.
FT DOMAIN 166..424
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
SQ SEQUENCE 426 AA; 48618 MW; F18D7EB0D8E15098 CRC64;
MSISGLFILD LKGNVVISRN YRGDVDMSCI EKFMPLLVEK EDEGSASPVL VHQGISYTYI
KYMNVYLVTI SKKNTNVILV LSALYKIVEV FCEYFKTLEE EAVRDNFVII YELFDEMLDF
GYPQTTESKI LQEFITQQGN RLETVRPPMA VTNAVSWRSE GIKYRKNEVF LDVIESVNML
ANAQGTVLRS EIVGSIRFRV VLSGMPELRL GLNDKVFFQQ SGASSRRGNS GKGVELEDIK
FHQCVRLSRF DSERTISFIP PDGEFELMSY RLTTQVKPLI WVEAAVERHA HSRVEYMVKA
KSQFKRQSVA NHVEVIIPVP SDVSAPKFKT GAGTAKYVPE LNAIVWSIRS FPGGREYIMR
SSFMLPSIGS EELEGRPPIN VKFEIPYYTT SGLQVRYLKI IEKSGYQALP WVRYVTQNGD
YQMRMT
//
