ID O02637_CAEEL Unreviewed; 319 AA.
AC O02637;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 27-MAR-2024, entry version 167.
DE RecName: Full=Carbonic anhydrase {ECO:0000256|RuleBase:RU367011};
DE EC=4.2.1.1 {ECO:0000256|RuleBase:RU367011};
GN Name=cah-6 {ECO:0000313|EMBL:CCD68362.1,
GN ECO:0000313|WormBase:T28F2.3};
GN ORFNames=CELE_T28F2.3 {ECO:0000313|EMBL:CCD68362.1}, T28F2.3
GN {ECO:0000313|WormBase:T28F2.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD68362.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD68362.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68362.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Reversible hydration of carbon dioxide.
CC {ECO:0000256|RuleBase:RU367011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718, ECO:0000256|RuleBase:RU367011}.
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DR EMBL; BX284601; CCD68362.1; -; Genomic_DNA.
DR PIR; T15137; T15137.
DR RefSeq; NP_491189.1; NM_058788.1.
DR AlphaFoldDB; O02637; -.
DR SMR; O02637; -.
DR DIP; DIP-24655N; -.
DR STRING; 6239.T28F2.3.1; -.
DR EPD; O02637; -.
DR PaxDb; 6239-T28F2-3; -.
DR PeptideAtlas; O02637; -.
DR EnsemblMetazoa; T28F2.3.1; T28F2.3.1; WBGene00000284.
DR EnsemblMetazoa; T28F2.3.2; T28F2.3.2; WBGene00000284.
DR GeneID; 189049; -.
DR KEGG; cel:CELE_T28F2.3; -.
DR UCSC; T28F2.3; c. elegans.
DR AGR; WB:WBGene00000284; -.
DR WormBase; T28F2.3; CE14355; WBGene00000284; cah-6.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000171339; -.
DR HOGENOM; CLU_039326_2_3_1; -.
DR InParanoid; O02637; -.
DR OMA; HWGTEPM; -.
DR OrthoDB; 49814at2759; -.
DR PhylomeDB; O02637; -.
DR Reactome; R-CEL-1475029; Reversible hydration of carbon dioxide.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000284; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004089; F:carbonate dehydratase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR CDD; cd03122; alpha_CARP_receptor_like; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR041887; Alpha_CARP_receptor-type.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF265; CARBONIC ANHYDRASE; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 1: Evidence at protein level;
KW Lyase {ECO:0000256|RuleBase:RU367011};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367011};
KW Proteomics identification {ECO:0007829|EPD:O02637,
KW ECO:0007829|PeptideAtlas:O02637};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367011}.
FT DOMAIN 41..306
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 319 AA; 35512 MW; B6B7C6BD7FFE4B1A CRC64;
MAFLSQLQGG FAQLKQKAEA AAPSIADSLN QLKEAPKFME SAFKTGLNKV KLDSLGKVLN
VPSLGRTQSP IDIVPVITAF GEHLQNAHFE VTYESTGEFK AVNDGNSIWL MREGNSSELA
ISFLPEEQYH LDAVNFHWAT EPMNGSEHTI GGVGYAGEMH LIHRNTRFAT MADALKQPNG
VIAIAVFLNE SHDDNAVFSP LINLLPQVIY KGSECKLCSF DFQTFFPVAE KTKEFWMYEG
SETTDPFRET VNWIVIRAAL PISSHQLDKL REVRAGRYDE EFSDKVPMKP LRPIQNPSSR
TIQSSFRSVA GAPDLGFRQ
//
