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Database: UniProt
Entry: O08459
LinkDB: O08459
Original site: O08459 
ID   SODM_HALHI              Reviewed;         144 AA.
AC   O08459;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   05-DEC-2018, entry version 78.
DE   RecName: Full=Superoxide dismutase [Mn];
DE            EC=1.15.1.1;
DE   Flags: Fragment;
GN   Name=sod;
OS   Haloarcula hispanica.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria;
OC   Halobacteriales; Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=51589;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9106366;
RA   Dennis P.P., Shimmin L.C.;
RT   "Evolutionary divergence and salinity-mediated selection in halophilic
RT   archaea.";
RL   Microbiol. Mol. Biol. Rev. 61:90-104(1997).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological
CC       systems.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000305}.
DR   EMBL; U78906; AAB60930.1; -; Genomic_DNA.
DR   PIR; T44915; T44915.
DR   ProteinModelPortal; O08459; -.
DR   SMR; O08459; -.
DR   eggNOG; arCOG04147; Archaea.
DR   eggNOG; COG0605; LUCA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 2.40.500.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Manganese; Metal-binding; Oxidoreductase.
FT   CHAIN        <1   >144       Superoxide dismutase [Mn].
FT                                /FTId=PRO_0000160118.
FT   METAL        42     42       Manganese. {ECO:0000250}.
FT   METAL       124    124       Manganese. {ECO:0000250}.
FT   METAL       128    128       Manganese. {ECO:0000250}.
FT   NON_TER       1      1
FT   NON_TER     144    144
SQ   SEQUENCE   144 AA;  15698 MW;  0F450B89D6439249 CRC64;
     GYVNGLESAE ETLAENRESG DFGSSAAAMG NVTHNGCGHY LHTLFWENMD PNGGGEPEGE
     LLDRIEEDFG SYEGWKGEFE AAASAAGGWA LLVYDPVAKQ LRNVPVDKHD QGALWGSHPI
     LALDVWEHSY YYDYGPARGD FIDA
//
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