ID O09242_9DELA Unreviewed; 993 AA.
AC O09242;
DT 01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT 01-JUL-1997, sequence version 1.
DT 24-JAN-2024, entry version 143.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AAB58786.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAB58786.1};
OS Simian T-lymphotropic virus 2.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus;
OC Primate T-lymphotropic virus 2.
OX NCBI_TaxID=33748 {ECO:0000313|EMBL:AAB58786.1};
RN [1] {ECO:0000313|EMBL:AAB58786.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9094642;
RA Digilio L., Giri A., Cho N., Slattery J., Markham P., Franchini G.;
RT "The simian T-lymphotropic/leukemia virus from Pan paniscus belongs to the
RT type 2 family and infects Asian macaques.";
RL J. Virol. 71:3684-3692(1997).
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DR EMBL; U90557; AAB58786.1; -; Genomic_DNA.
DR Proteomes; UP000130460; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000130460};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195}.
FT DOMAIN 144..334
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 554..695
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 751..909
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAB58786.1"
SQ SEQUENCE 993 AA; 110519 MW; 3F1BE408967A04D2 CRC64;
QGLISPSCPR PLPPSQKVSD TTVLGAGGQT SSQFKLLRSP LCVYLPFRKA PVTLPSCLLD
TDNKWAIIGR DILQQCQSVL YLPEDNLCEG TPRPSGRMNS PRLLPVATPS VIGLEHFPPP
PQIDQFPFKP ERLQALTDLV SKALEASYIE PYSGPGNNPV FPVKKPNGKW RFIHDLRATN
AITTTLASPS PGPPDLTSLS TALPYVQTID LADAFFQIPL PKQFQPYFAF TIPQPCNYGP
GARYAWTVLP QGFKNSPTLF EQQLAAILSP IRKAFPTSTI IQYMDDILLA SPAQGELQQL
SKMTLQALVT HGLPVSQAPR EQTPGQIRFL GQVISPDHIT YETTPTIPMK SQWTLAELQT
VLGEIQWVSK GTPILRKHLQ CLYSALRGYQ DPRAHLLLQK QQLHALHAIQ PLQHNCRSRL
NPALPILGLI SLSSSGTTSV LFQARQRWPL VWLHTPHPPT SLGPWGHLLA CTILTLDKYS
LQHYGRLCQS LEDNMSNTAL HDFVKNSPHP RVGILIHHMS RFHNLGSQPS GPWKALLHLP
ALLQAARLLR PLFTLSPVVL TTHPVSSPTG LPKKAAYVLW DQTILRHDSI TLPPHGSNSA
QRGELLALLS GLRAAKSWPS LNIFLDSKYL IKYLHSLATG AFLGTSTHQS LYAHLPALLH
NKVIYLHHIR SHTNLPDPIS TLNEYTDSLI IIAPLIPLTP QDLHRLTHCN SRGPCFFRAT
PQQSQVALES RVTPATSLNS QHHMPQGHIR RGLLPNHIWQ GDVTHYKYKR HRYCLHVWVD
TFSNAVSITC KTKETSSETV SALLHAITIL GKPLSINTDN GSAFLSQEFQ AFCTSWHIRH
STHVPYNPTS SGLVERTNGI VKALLNKYLL DSPNLPLDNA ISKSLWTLNQ LNVMSPSGKT
RWQLHHGPRL PPSLQIPQPS KAPANWYYVL TPGLTNQRWK GPLHLSRKLQ ERLLSIDGSP
QWIPWRLLKK TVCPRPDGSE LAAHAATDHQ HHG
//