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Database: UniProt
Entry: O11408_9PLVG
LinkDB: O11408_9PLVG
Original site: O11408_9PLVG 
ID   O11408_9PLVG            Unreviewed;       263 AA.
AC   O11408;
DT   01-JUL-1997, integrated into UniProtKB/TrEMBL.
DT   01-JUL-1997, sequence version 1.
DT   12-AUG-2020, entry version 105.
DE   RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344};
GN   Name=nef {ECO:0000313|EMBL:AAC57428.1};
OS   Simian-Human immunodeficiency virus.
OC   Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC   Primate lentivirus group; unclassified Primate lentivirus group.
OX   NCBI_TaxID=57667 {ECO:0000313|EMBL:AAC57428.1};
RN   [1] {ECO:0000313|EMBL:AAB99977.1, ECO:0000313|Proteomes:UP000157732}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SHIV-4 {ECO:0000313|EMBL:AAB99977.1};
RX   PubMed=1613662;
RA   Li J., Lord C.I., Haseltine W., Letvin N.L., Sodroski J.;
RT   "Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that
RT   expresses the HIV-1 envelope glycoproteins.";
RL   J. Acquir. Immune Defic. Syndr. 5:639-646(1992).
RN   [2] {ECO:0000313|EMBL:AAB99967.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-89.6 {ECO:0000313|EMBL:AAB99967.1};
RX   PubMed=8627800;
RA   Reimann K.A., Li J.T., Voss G., Lekutis C., Tenner-Racz K., Racz P.,
RA   Lin W., Montefiori D.C., Lee-Parritz D.E., Lu Y., Collman R.G.,
RA   Sodroski J., Letvin N.L.;
RT   "An env gene derived from a primary human immunodeficiency virus type 1
RT   isolate confers high in vivo replicative capacity to a chimeric
RT   simian/human immunodeficiency virus in rhesus monkeys.";
RL   J. Virol. 70:3198-3206(1996).
RN   [3] {ECO:0000313|EMBL:AAC57428.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-89.6P {ECO:0000313|EMBL:AAC57428.1};
RX   PubMed=9151808;
RA   Karlsson G.B., Halloran M., Li J., Park I.W., Gomila R., Reimann K.A.,
RA   Axthelm M.K., Iliff S.A., Letvin N.L., Sodroski J.;
RT   "Characterization of molecularly cloned simian-human immunodeficiency
RT   viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.";
RL   J. Virol. 71:4218-4225(1997).
RN   [4] {ECO:0000313|EMBL:AAB99967.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SHIV-4 {ECO:0000313|EMBL:AAB99977.1}, and SHIV-89.6
RC   {ECO:0000313|EMBL:AAB99967.1};
RA   Reimann K.A., Li J.T., Voss G., Lekutis C., Tenner-Racz K., Racz P.,
RA   Lin W., Montefiori D.C., Lee-Parritz D.E., Lu Y., Collman R.G.,
RA   Sodroski J., Letvin N.L.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAD12143.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9882298;
RA   Cayabyab M., Karlsson G.B., Etemad-Moghadam B.A., Hofmann W., Steenbeke T.,
RA   Halloran M., Fanton J.W., Axthelm M.K., Letvin N.L., Sodroski J.G.;
RT   "Changes in human immunodeficiency virus type 1 envelope glycoproteins
RT   responsible for the pathogenicity of a multiply passaged simian-human
RT   immunodeficiency virus (SHIV-HXBc2).";
RL   J. Virol. 73:976-984(1999).
RN   [6] {ECO:0000313|EMBL:QHI08135.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AD8_EO {ECO:0000313|EMBL:QHI08135.1};
RX   PubMed=23129652;
RA   Shingai M., Donau O.K., Schmidt S.D., Gautam R., Plishka R.J.,
RA   Buckler-White A., Sadjadpour R., Lee W.R., LaBranche C.C., Montefiori D.C.,
RA   Mascola J.R., Nishimura Y., Martin M.A.;
RT   "Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate
RT   cross-reactive antibodies that neutralize multiple HIV-1 strains.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:19769-19774(2012).
RN   [7] {ECO:0000313|EMBL:APS90965.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Foulke J.S.Jr., DeVico A., Reitz M.;
RT   "Clade B T/F SHIV pSF257.2.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:QHI08135.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AD8_EO {ECO:0000313|EMBL:QHI08135.1};
RA   Sadjadpour R.;
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein family.
CC       {ECO:0000256|ARBA:ARBA00006933, ECO:0000256|RuleBase:RU000344}.
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DR   EMBL; AF038398; AAB99967.1; -; Other_DNA.
DR   EMBL; AF038399; AAB99977.1; -; Other_DNA.
DR   EMBL; U89134; AAC57428.1; -; Other_DNA.
DR   EMBL; AF041850; AAD12143.1; -; Other_DNA.
DR   EMBL; KU521530; APS90965.1; -; Other_DNA.
DR   EMBL; MN816822; QHI08135.1; -; Other_DNA.
DR   Proteomes; UP000157732; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.62.10; -; 1.
DR   InterPro; IPR027481; HIV-1_Nef_core_sf.
DR   InterPro; IPR001558; HIV_Nef.
DR   Pfam; PF00469; F-protein; 1.
DR   SUPFAM; SSF55671; SSF55671; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Lipoprotein {ECO:0000256|RuleBase:RU000344};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU000344};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280,
KW   ECO:0000256|RuleBase:RU000344};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|RuleBase:RU000344}.
SQ   SEQUENCE   263 AA;  30416 MW;  613576BC7DC5603E CRC64;
     MGGAISMRRS RPSGDLRQRL LRARGETYGR LLGEVEDGYS QSPGGLDKGL SSLSCEGQKY
     NQGQYMNTPW RNPAEEREKL AYRKQNMDDI DEEDDDLVGV SVRPKVPLRT MSYKLAIDMS
     HFIKEKGGLE GIYYSARRHR ILDIYLEKEE GIIPDWQDYT SGPGIRYPKT FGWLWKLVPV
     NVSDEAQEDE EHYLMHPAQT SQWDDPWGEV LAWKFDPTLA YTYEAYVRYP EEFGSKSGLS
     EEEVRRRLTA RGLLNMADKK ETR
//
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