ID O16331_CAEEL Unreviewed; 1054 AA.
AC O16331;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 2.
DT 27-MAR-2024, entry version 181.
DE SubName: Full=Cation-transporting P-type ATPase N-terminal domain-containing protein {ECO:0000313|EMBL:CCD64050.1};
GN Name=catp-3 {ECO:0000313|EMBL:CCD64050.1,
GN ECO:0000313|WormBase:C09H5.2a};
GN ORFNames=C09H5.2 {ECO:0000313|WormBase:C09H5.2a}, CELE_C09H5.2
GN {ECO:0000313|EMBL:CCD64050.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD64050.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD64050.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD64050.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284605; CCD64050.1; -; Genomic_DNA.
DR PIR; T31763; T31763.
DR RefSeq; NP_505083.1; NM_072682.4.
DR AlphaFoldDB; O16331; -.
DR SMR; O16331; -.
DR STRING; 6239.C09H5.2a.1; -.
DR EPD; O16331; -.
DR PaxDb; 6239-C09H5-2a; -.
DR PeptideAtlas; O16331; -.
DR EnsemblMetazoa; C09H5.2a.1; C09H5.2a.1; WBGene00015660.
DR GeneID; 179189; -.
DR KEGG; cel:CELE_C09H5.2; -.
DR UCSC; C09H5.2a; c. elegans.
DR AGR; WB:WBGene00015660; -.
DR WormBase; C09H5.2a; CE24797; WBGene00015660; catp-3.
DR eggNOG; KOG0203; Eukaryota.
DR GeneTree; ENSGT00970000196544; -.
DR HOGENOM; CLU_002360_4_1_1; -.
DR InParanoid; O16331; -.
DR OMA; PTSCQVI; -.
DR OrthoDB; 203629at2759; -.
DR PhylomeDB; O16331; -.
DR Reactome; R-CEL-936837; Ion transport by P-type ATPases.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00015660; Expressed in material anatomical entity and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IBA:GO_Central.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43294:SF5; CATION_ATPASE_N DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Proteomics identification {ECO:0007829|EPD:O16331,
KW ECO:0007829|PeptideAtlas:O16331};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT TRANSMEM 103..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..1002
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1014..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..120
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 1054 AA; 117374 MW; 4B58A6E3A923487C CRC64;
MGFLLGVVRS LRQRREAADS ENSSFKEATH KDLSSSFVEH QMHIAQLSER FFHSKIDIVE
PKKSKGLTKQ EAAQKLKTDG KNALSPPKTI SNMELFVRQF KNLLWVLMFG AAALCFLTYI
YDPTDALNLY VGIFIVAIVF IMCVVSFFEE KKGVEVVRAF QTLMPTSCQV IRDGKEILLN
PEELVVGDVV VVRSGCKVPA DMRIIACTDF FLETSSITGE AEPLEFHSKT ADAKTSIFES
YNIAFNGSFC VDGEGYGIII RTGENTVIGQ IASLTLGQKD KKCKFETEIE RFVQFITVMA
ITMATVIFTI GLLVNGGNDV IRLFVTGFLM VIIANVPQGL PTTVTTELTI IARRMAKKNV
FLKKLEKIDS VGATTLIASD KTGTLTKNCM TVTDLWYNNS YNSARPENQG RTTKKRNLNA
INTIGWYDAP LKDILSVICV CNKARIENNL TTKVRPPRVD SELDLTVYKS QPVKEMLISG
NPSEVALLRY ASGMLDAMEV RDSFHVVFEV PFNSVRKYHL ILATTEATWA EIDDKKKVNA
DVEFILMIKG APDVLIKSCS TINIDGVPME LNGKRMDDFN EAYETFGDEG CRVIGFACKK
FRAPATSTFS IKSNTIPMDN WDFLGMSAIM DPPRDDTPRA IKACKEAGIK VYMVTGDHKS
TATAIARQIG MIDTEEVTNL DHNRQVIRRT NSQDWAVITG PELPGLSEKQ WDALLEHRYI
VFARTTPEHK LMIVTESQKR GECVTVTGDG VNDAPALKKA DVGVAMGLAG SDVAKQAADI
ILLDDNFSSI VAGIEEGRLL FDNLRKTIAY TMTHMWPELV PVMLNFFFGF PLGLTPVQIL
SIDLITDIPP AVSLAYEGPE ADIMLQPPRK RETHLVTKGL ITYTYLFMSI FISVGGVVAY
LLSYYLNGIY PSELAFSSND HFKVGASNFT TYNGVVLNAE QQVFMAAQAA AAFHIAVVVG
QAWHLWMCLT RRVSIFVHGM ANIVAILAVI IDLLLICLFT FVPGVQYVFG SQPPPWECWL
VPVIVGIWIW IFNELRKFGI RNYPKNKLVR LVKW
//
