GenomeNet

Database: UniProt
Entry: O16426_CAEEL
LinkDB: O16426_CAEEL
Original site: O16426_CAEEL 
ID   O16426_CAEEL            Unreviewed;       371 AA.
AC   O16426;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 5.
DT   18-SEP-2019, entry version 149.
DE   SubName: Full=Ligand-Gated ion Channel {ECO:0000313|EMBL:CCD70839.3};
GN   Name=lgc-1 {ECO:0000313|EMBL:CCD70839.3,
GN   ECO:0000313|WormBase:T05B4.1};
GN   ORFNames=CELE_T05B4.1 {ECO:0000313|EMBL:CCD70839.3}, T05B4.1
GN   {ECO:0000313|WormBase:T05B4.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70839.3, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD70839.3, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70839.3,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; BX284605; CCD70839.3; -; Genomic_DNA.
DR   STRING; 6239.T05B4.1; -.
DR   PaxDb; O16426; -.
DR   EnsemblMetazoa; T05B4.1.1; T05B4.1.1; WBGene00020236.
DR   UCSC; T05B4.1; c. elegans.
DR   WormBase; T05B4.1; CE41156; WBGene00020236; lgc-1.
DR   eggNOG; KOG3645; Eukaryota.
DR   eggNOG; ENOG410XQGR; LUCA.
DR   GeneTree; ENSGT00970000195874; -.
DR   HOGENOM; HOG000019212; -.
DR   InParanoid; O16426; -.
DR   OMA; QNICAES; -.
DR   OrthoDB; 1037615at2759; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00020236; Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans).
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 2.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Ion channel {ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000687}.
FT   TRANSMEM    235    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    267    285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    297    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    344    370       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       17    186       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      242    344       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
SQ   SEQUENCE   371 AA;  42644 MW;  CD496951A39274CF CRC64;
     MTKAEMATYN KFLADQKRLW DDLFKDYDPT LSAIYTLHKS QWINQTATIH PPITELKLTM
     AMLKLVDVVE VEEKVTFLFD YLAEWTDQRL KWNPLEYGGI SHIYVPQRMI WLPEVTIADA
     HEVKFFESDD APRTAWINYN GTTGFYTSTV SSVICQLDVY KFPLDRHECG VSVLFHTYFA
     DEYVIKSDME PLPKPLSQLG NGEWKVTYIG VAEEIGNGNF SAVQRFVARI ERNPGFYVTL
     VMVPAFFINF LSIIALCLNI ENVGEKITVG LTNIMAMTFI LVILAQDLPK TKRIPLLAIY
     VIVGLVIVMA SIGVVLTLPL IRNHLKKRQK GKEEKPVETR FSKWFGWLTV EYVVMFVFQL
     ANLINFIILF I
//
DBGET integrated database retrieval system