ID O16632_CAEEL Unreviewed; 1193 AA.
AC O16632;
DT 01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 152.
DE SubName: Full=ANK_REP_REGION domain-containing protein {ECO:0000313|EMBL:CCD70874.1};
GN ORFNames=CELE_K02F6.4 {ECO:0000313|EMBL:CCD70874.1}, K02F6.4
GN {ECO:0000313|EMBL:CCD70874.1, ECO:0000313|WormBase:K02F6.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70874.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70874.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70874.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284602; CCD70874.1; -; Genomic_DNA.
DR PIR; T32016; T32016.
DR RefSeq; NP_494293.1; NM_061892.1.
DR AlphaFoldDB; O16632; -.
DR EPD; O16632; -.
DR PaxDb; 6239-K02F6-4; -.
DR PeptideAtlas; O16632; -.
DR EnsemblMetazoa; K02F6.4.1; K02F6.4.1; WBGene00019338.
DR GeneID; 186907; -.
DR KEGG; cel:CELE_K02F6.4; -.
DR UCSC; K02F6.4; c. elegans.
DR AGR; WB:WBGene00019338; -.
DR WormBase; K02F6.4; CE11662; WBGene00019338; -.
DR eggNOG; ENOG502TH2A; Eukaryota.
DR GeneTree; ENSGT00970000195865; -.
DR HOGENOM; CLU_004160_0_0_1; -.
DR InParanoid; O16632; -.
DR OMA; LENETMF; -.
DR OrthoDB; 2883904at2759; -.
DR PhylomeDB; O16632; -.
DR Proteomes; UP000001940; Chromosome II.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR003125; WSN.
DR PANTHER; PTHR22956:SF18; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22956; ANKYRIN REPEAT-CONTAINING PROTEIN F37A4.4-RELATED-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF02206; WSN; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00453; WSN; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 781..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..94
FT /note="Domain of unknown function WSN"
FT /evidence="ECO:0000259|SMART:SM00453"
FT REPEAT 875..907
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 945..1035
FT /note="BRCT"
FT /evidence="ECO:0000259|SMART:SM00292"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1193 AA; 134335 MW; 0F531053D81F404F CRC64;
MHQAQTKLFR KFSQNHSPPP PRRSSALHDA IDKLSIVARV TNAITIQKGL NDKSMKMANL
LDELLNIPPG DGFSNLQTLD LKKAKEGYIG IAKDAGALTK SSLDGAKNAQ RLKHLGDMGK
NVEMLKKAEA ADLTDAIGKV TGSFDISTSL ITTSLKPVSE HLNLLLKNKW TPDTDQRAKE
CINSLKSSLG SLGSTLREAS KYEDSLKLLW SVINISQSFD VVERLGVVAK TYHNQFNEIR
QLSKDFKNTK EEFTKLDSFF KQFSLLRLLK DSISKSLKIR STTPSNSTKP RLLTSGFLNG
LGNVQAVKKD LNNEWFLKKI ARNDKSSLIV LKQYLRFFET VSSKSVEMET VFTPLRTISA
KPIETSETLL NSAVEVYVNP TQLQTFQKSI LEVGECIDKL GQMTANVNFE TFQKTIQNLK
SFDTSASKTR SLLKKIVELN VLGDRSVFDQ LRTDINNINT SLPIGEYFSN IITMRANKNY
LKIVEGVATV YEYFEEIGQL HIDIVITNLN TSLPIITQMQ PVLKGTNLVD TLECLKNKNF
NSSLASDVLK FGSNIRAFGV HAKNDKATIS FLDLISKLQN LYFSVKKSLD GKRTRRATGS
IDPTKLPNLL ASQDLGKGLQ LLRQLSEVNN KKKIVTDVTK FSDSVFAEVQ KILKTVDTST
LKPELKKMLL DLTNLESFAS NHTGQGLREL GAIFEKASEV SGVTVNSSLL EDPVAKTLST
SAVNDIKKAA PSFKTLGSLE LNYANHRSTF KGASLCIVKI DEFFSDFFAA GGNVESSSGT
LYVGVVGGIA LLIGAGVGGF LLWKHLDMLK LLKNPVNYRH SAFTIPEGEM RYDEISETNR
HLSIHSAISD RNFERFKNCV DNSADVNAYS CHSNYYSTPL HMAVTRNLVQ FVAYLLKNGA
DPSKMDSNYQ LPAKLAEKTE KKEELLAMFN KYSRGKKTHR KLPKFGPSDY KVWIHYNDMM
AEAGEADTDV KEAFVKMFPK NMVTDAREAT HIILPTDEKG VLSFDVRGDK EMFPYIFRET
VLMKNSWMTA CLKDKKNFAD DYKFQVEGVE MKSETFNTVR LIHQHAQQYQ IPYLAGVTMY
YHQFPETPDT TFENLVRDLG ADVRQDLRYL DRQNTVTASP YYRDDIGPVF IITKSKDELV
KEYAFVKNNN CYTIFTYYEF LQFLLAFKIT HWKLTGKKEP NCIEKWDELK QSK
//
