ID STDH4_CAEEL Reviewed; 263 AA.
AC O16925;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 131.
DE RecName: Full=Putative steroid dehydrogenase 4;
DE EC=1.1.1.-;
GN Name=stdh-4; Synonyms=tag-57; ORFNames=F25G6.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080489; CCD64105.2; -; Genomic_DNA.
DR PIR; D89134; D89134.
DR RefSeq; NP_505205.2; NM_072804.2.
DR AlphaFoldDB; O16925; -.
DR SMR; O16925; -.
DR STRING; 6239.F25G6.5b.1; -.
DR PaxDb; 6239-F25G6-5; -.
DR EnsemblMetazoa; F25G6.5a.1; F25G6.5a.1; WBGene00006435.
DR GeneID; 184934; -.
DR KEGG; cel:CELE_F25G6.5; -.
DR AGR; WB:WBGene00006435; -.
DR WormBase; F25G6.5a; CE47137; WBGene00006435; stdh-4.
DR eggNOG; KOG1014; Eukaryota.
DR GeneTree; ENSGT00940000165708; -.
DR HOGENOM; CLU_010194_38_0_1; -.
DR InParanoid; O16925; -.
DR OMA; HEHPIAM; -.
DR PhylomeDB; O16925; -.
DR PRO; PR:O16925; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00006435; Expressed in material anatomical entity and 2 other cell types or tissues.
DR ExpressionAtlas; O16925; baseline.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05356; 17beta-HSD1_like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43086:SF1; STEROID DEHYDROGENASE 1-RELATED; 1.
DR PANTHER; PTHR43086; VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR PIRSF; PIRSF000126; 11-beta-HSD1; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase;
KW Reference proteome; Steroid biosynthesis.
FT CHAIN 1..263
FT /note="Putative steroid dehydrogenase 4"
FT /id="PRO_0000054582"
FT ACT_SITE 154
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
SQ SEQUENCE 263 AA; 29521 MW; 4175D4AA01E80D50 CRC64;
MKVVTGATDG IGRSYALDLA RRGFNIFLIS RTKSKLVKTK KQILNKYSDI EVRYAICDFT
RVSYEDYKRL LHSLNEVDIG ILINNVGMCF DNPEVLHRVE GGIDTLTNVI NVNILPVTLL
TAGILPQMMA RKSGIIVNIG SAAGSIHMAK WSVYSATKKY IEWFTSILQK EYENEGIICQ
TITPLLVSTN MIKNPLSSIF CPNSDSFAKS SLNTIGNSSS TTGYITHQIQ FELIKFVPEI
IIDLFVKNLN NQLLDYQLDK KRV
//
